Abstract
Biomarkers of cardiac stretch, particularly natriuretic peptides, are a fundamental component in the diagnosis and management of cardiac dysfunction in many clinical settings. The utility of these cardiac biomarkers have become of interest in critically ill and could play a role in predicting adverse outcomes and prognosticating in a number of cardiac and extracardiac conditions in intensive care. In this chapter, we review the evidence for the clinical utility of biomarkers of cardiac stretch in different critical illness syndromes. We also review the potential mechanisms that may explain the association between elevated biomarkers of cardiac stretch and adverse outcomes.
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Abbreviations
- ANP:
-
Atrial natriuretic peptide
- ARDS:
-
Acute respiratory distress syndrome
- BNP:
-
Brain natriuretic peptide
- COPD:
-
Chronic obstructive pulmonary disease
- COVID-19:
-
Coronavirus disease 2019
- EuroSCORE:
-
European System for Cardiac Operative Risk Evaluation
- ICU:
-
Intensive care unit
- MR-proANP:
-
Midregional pro-atrial natriuretic peptide
- NT-proANP:
-
N terminal pro-atrial natriuretic peptide
- NT-proBNP:
-
N terminal pro-brain natriuretic peptide
- pg/ml:
-
Picograms per milliliter
- RAAS:
-
Renin-angiotensin-aldosterone system
- RV:
-
Right ventricle
- SARI:
-
Severe acute respiratory infection
- TBI:
-
Traumatic brain injury
- VA ECMO:
-
Venoarterial extracorporeal membrane oxygenation
- VV ECMO:
-
Venovenous extracorporeal membrane oxygenation
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Jayasimhan, D., Hancox, R.J. (2022). Biomarkers of Cardiac Stretch in Critical Illness: A Narrative Review. In: Rajendram, R., Preedy, V.R., Patel, V.B. (eds) Biomarkers in Trauma, Injury and Critical Care. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-87302-8_70-1
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