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Maternal Diabetes and Obesity

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Benirschke's Pathology of the Human Placenta

Abstract

Diabetes mellitus during pregnancy may be pregestational (type 1 diabetes mellitus or type 2 diabetes mellitus) or gestational. Obesity and type 2 diabetes mellitus have become escalating global health problems. Obesity is a major risk factor for gestational diabetes mellitus and pregestational type 2 diabetes mellitus. Both diabetes and obesity during pregnancy can lead to adverse maternal and neonatal outcomes and epigenetic changes in the baby that lead to increased disease risk later in life. While the placentas from pregnancies complicated by diabetes and obesity have been extensively studied, currently there are no signature pathological changes reported. The changes described are largely morphological adaptions or alterations to the known hormonal, metabolic, and inflammatory profiles associated with diabetes and obesity.

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Acknowledgement

Electron Microcopy photographs are reproduced by kind permission of Dr. Carolyn J.P. Jones, University of Manchester, United Kingdom.

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Authors and Affiliations

  1. The Canberra Hospital and Australian National University Medical School, Department of Anatomical Pathology, ACT Pathology, Woden, Australia

    Jane Esther Dahlstrom

  2. The Canberra Hospital and Australian National University Medical School, Department of Endocrinology, Woden, Australia

    Christopher James Nolan

  3. Medical University of Graz, Graz, Austria

    Gernot Desoye

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  1. Jane Esther Dahlstrom
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  2. Christopher James Nolan
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  3. Gernot Desoye
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Correspondence to Jane Esther Dahlstrom .

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Editors and Affiliations

  1. Professor of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA

    Rebecca N. Baergen

  2. Centre for Trophoblast Research, University of Cambridge, Cambridge, UK

    Graham J. Burton

  3. Professor Emeritus of Pathology, State University of New York, Stony Brook, NY, USA

    Cynthia G. Kaplan

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Dahlstrom, J.E., Nolan, C.J., Desoye, G. (2022). Maternal Diabetes and Obesity. In: Baergen, R.N., Burton, G.J., Kaplan, C.G. (eds) Benirschke's Pathology of the Human Placenta. Springer, Cham. https://doi.org/10.1007/978-3-030-84725-8_20

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