Abstract
The microneedle-based delivery of therapeutics has been driving innovations in drug delivery research. The micron-scale needles arranged in an array format within a small area would breach the outermost epidermal/epithelial barriers without causing discernible invasion. The minimally invasive microneedle patches allow greater acceptability for drug delivery through the transdermal, ocular, and oral cavity routes. Microneedle patches have evolved with fabrication technologies, materials of construction, and application capabilities. The solid microneedle designs made of biocompatible materials and fabricated using micromolding techniques have been the widely studied models. Microneedle patches have been investigated to deliver small molecule agents, peptide and protein therapeutics, and antigens for immunization. It has been identified that microneedle patches are most suitable to deliver potent compounds that require less than a milligram of dose. Therefore, the initial clinical trials on the utilization of microneedle patches have been to investigate the delivery of vaccine agents. The chapter provides an in-depth review of the potential of polymeric microneedle patches to deliver therapeutics across traditional drug delivery barriers.
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Chauhan, S.S., Lobo, V.M., Borate, S.N., Jagade, S.S., Venuganti, V.V.K. (2021). Microneedle Array Patches for the Delivery of Therapeutic Agents. In: Kim, JC., Alle, M., Husen, A. (eds) Smart Nanomaterials in Biomedical Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-84262-8_9
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