Abstract
Due to the lack of awareness and inappropriate use of antibiotics, as well as the ability of bacteria to cross-transmit antibiotic resistance, there is a significant increase in the number of multidrug-resistant strains worldwide. For this purpose, in order to be applied as an antimicrobial treatment approach in the coming years, there have been attempts to reduce the virulence of bacteria, as well as phage uses through alternative treatment methods based on aromatic and medicinal plants, in addition to new drug development studies. In this context, among the most important research is the usability of plants, plant-based herbs, spices, and essential oils as antimicrobial agents. Medicinal and aromatic plants are considered to be natural flora sources that are important in various fields, such as the pharmaceutical, food, cosmetics, chemical, and fragrance industries, and a large part of the current world population uses traditional plant-based alternative agents to treat different problems that threaten human health. One of the most researched alternative plant sources is cinnamon, which is a tropical spice in the genus Cinnamomum, in which over 200 species have been identified. Cinnamon is known to have antioxidant, antidiabetic, anti-inflammatory, antiquorum sensing, insecticide, and anticancer effects in addition to its antibacterial and antifungal, that is, antimicrobial activities. Cinnamon has also been reported to inhibit allergen-specific immune responses, in addition to reducing the side effects of some anti-inflammatory drugs, such as gelofen, through its antioxidant properties.
In this chapter, the antimicrobial properties of cinnamon, together with its content and effectiveness, are discussed in light of the research and clinical studies on this subject.
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Abbreviations
- A. baumannii:
-
Acinetobacter baumannii
- C. albicans :
-
Candida albicans
- C. cassia :
-
Cinnamomum cassia
- C. zeylanicum :
-
Cinnamomum zeylanicum
- CO:
-
Cinnamon oil
- E. coli :
-
Escherichia coli
- EO:
-
Essential oil
- HIV:
-
Human immunodeficiency virus
- IC50:
-
The half maximal inhibitory concentration
- L. monocytogenes :
-
Listeria monocytogenes
- MIC:
-
Minimal inhibitory concentration
- MRSA:
-
Methicillin-resistant Staphylococcus aureus
- P. aeruginosa :
-
Pseudomonas aeruginosa
- QS:
-
Quorum sensing
- R. nigricans :
-
Rhizopus nigricans
- S. aureus :
-
Staphylococcus aureus
- S. mutans :
-
Streptococcus mutans
- SARS-CoV:
-
Severe acute respiratory syndrome coronavirus
References
Akthar M, Degaga B, Azam T (2014) Antimicrobial activity of essential oils extracted from medicinal plants against the pathogenic microorganisms: a review. Issues Biol Sci Pharm Res 2(1):1–7
Alibi S, Ben Selma W, Ramos-Vivas J, Smach MA, Touati R, Boukadida J, Navas J, Ben Mansour H (2020) Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates. Curr Res Transl Med 68(2):59–66. https://doi.org/10.1016/j.retram.2020.01.001
Anlar HG, Bacanli M, Çal T, Aydin S, Ari N, Ündeğer Bucurgat Ü, Başaran AA, Başaran AN (2018) Effects of cinnamic acid on complications of diabetes. Turk J Med Sci 48(1):168–177. https://doi.org/10.3906/sag-1708-8
Arumugam G, Swamy MK, Sinniah UR (2016) Plectranthus amboinicus (Lour.) Spreng: botanical, phytochemical, pharmacological and nutritional significance. Molecules 21(4):369. https://doi.org/10.3390/molecules21040369
Azizkhani M, Tooryan F (2016) Effect of cinnamon, rosemary and zataria essential oils on food-borne gastroenteritis viruses. J Maz Univ Med Sci 26(141):8–15
Bae KH, Ji JM, Park KL (1992) The antibacterial component from Cinnamomi Cortex against a cariogenic bacterium Streptococcus mutans OMZ 176. Arch Pharm Res 15(3):239–241. https://doi.org/10.1007/BF02974062
Balijepalli MK, Buru AS, Sakirolla R, Pichika MR (2017) Cinnamomum genus: a review on its biological activities. Cinnamomum genus: A review on its biological activities. Int J Pharm Pharm Sci 9(2):1–11. https://doi.org/10.22159/ijpps.2017v9i2.11156
Blumenthal M, Goldberg A, Brinckmann J (2000) Herbal medicine: expanded commission E monographs. Integrative Medicine Communications, Boston
Brochot A, Guilbot A, Haddioui L, Roques C (2017) Antibacterial, antifungal, and antiviral effects of three essential oil blends. MicrobiologyOpen 6(4):1–6. https://doi.org/10.1002/mbo3.459
Cheng SS, Liu JY, Huang CG, Hsui YR, Chen WJ, Chang ST (2009) Insecticidal activities of leaf essential oils from Cinnamomum osmophloeum against three mosquito species. Bioresour Technol 100(1):457–464. https://doi.org/10.1016/j.biortech.2008.02.030
Çolak Ç, Elibol E, Demir T, Kıvçak B (2018) Overdose of cinnamon barks is the cause of poisoning in the gediatric patient: case report. J US China Med Sci 15(1):1–3. https://doi.org/10.17265/1548-6648/2018.01.004
Cui H, Zhou H, Lin L, Zhao CT, Zhang XJ, Xiao ZH, Li C (2016) Antibacterial activity and mechanism of cinnamon essential oil and its application in milk. J Anim Plant Sci 26(2):532–541
de Oliveira Carvalho I, Purgato GA, Piccolo MS, Pizziolo VR, Coelho RR, Diaz-Munoz G, Alves Nogueira Diaz M (2020) In vitro anticariogenic and antibiofilm activities of toothpastes formulated with essential oils. Arch Oral Biol 117:104834. https://doi.org/10.1016/j.archoralbio.2020.104834
Deng X, Liao Q, Xu X, Yao M, Zhou Y, Lin M, Zhang P, Xie Z (2014) Analysis of essential oils from cassia bark and cassia twig samples by GC-MS combined with multivariate data analysis. Food Anal Methods 7:1840–1847. https://doi.org/10.1007/s12161-014-9821-y
Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, Koren G (2007) From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Can J Physiol Pharmacol 85(9):837–847. https://doi.org/10.1139/Y07-080
Edis Z, Haj BS, Ashames A, Ibrahim M (2019) Copper-based nanoparticles, their chemistry and antibacterial properties: a review. In: Ramasami P, Gupta Bhowon M, Jhaumeer Laulloo S, Li Kam Wah H (eds) Chemistry for a clean and healthy planet. Springer, Cham, pp 401–428
Edis Z, Haj Bloukh S, Ibrahim MR, Abu Sara H (2020) “Smart” antimicrobial nanocomplexes with potential to decrease surgical site infections (SSI). Pharmaceutics 12(4). https://doi.org/10.3390/pharmaceutics12040361
Eleraky NE, Allam A, Hassan SB, Omar MM (2020) Nanomedicine fight against antibacterial resistance: an overview of the recent pharmaceutical innovations. Pharmaceutics 12(2). https://doi.org/10.3390/pharmaceutics12020142
Fabra MJ, Castro-Mayorga JL, Randazzo W, Lagaron JM, Lopez-Rubio A, Aznar R, Sanchez G (2016) Efficacy of cinnamaldehyde against enteric viruses and its activity after incorporation into biodegradable multilayer systems of interest in food packaging. Food Environ Virol 8(2):125–132. https://doi.org/10.1007/s12560-016-9235-7
Fathima HM, Rajasekar A, Rajeshkumar S (2020) Antifungal activity of cinnamon – clove mediated silver nanoparticles against Candida albicans. Plant Cell Biotechnol Mol Biol 21(27–28):21–27
Fatima M, Zaidi NU, Amraiz D, Afzal F (2016) In vitro antiviral activity of Cinnamomum cassia and its nanoparticles against H7N3 influenza a virus. J Microbiol Biotechnol 26(1):151–159. https://doi.org/10.4014/jmb.1508.08024
Fauvelle C, Lambotin M, Heydmann L, Prakash E, Bhaskaran S, Vishwaraman M, Baumert TF, Moog C (2017) A cinnamon-derived procyanidin type a compound inhibits hepatitis C virus cell entry. Hepatol Int 11(5):440–445. https://doi.org/10.1007/s12072-017-9809-y
Felgueiras HP, Homem NC, Teixeira MA, Ribeiro ARM, Antunes JC, Amorim MTP (2020) Physical, thermal, and antibacterial effects of active essential oils with potential for biomedical applications loaded onto cellulose acetate/polycaprolactone wet-spun microfibers. Biomol Ther 10(8). https://doi.org/10.3390/biom10081129
Filoche SK, Soma K, Sissons CH (2005) Antimicrobial effects of essential oils in combination with chlorhexidine digluconate. Oral Microbiol Immunol 20(4):221–225. https://doi.org/10.1111/j.1399-302X.2005.00216.x
Fouad AF (2017) Endodontic microbiology and pathobiology: current state of knowledge. Dent Clin N Am 61(1):1–15. https://doi.org/10.1016/j.cden.2016.08.001
Guerra FQ, Mendes JM, Sousa JP, Morais-Braga MF, Santos BH, Melo Coutinho HD, Lima Ede O (2012) Increasing antibiotic activity against a multidrug-resistant Acinetobacter spp by essential oils of Citrus Limon and Cinnamomum zeylanicum. Nat Prod Res 26(23):2235–2238. https://doi.org/10.1080/14786419.2011.647019
Hayashi K, Imanishi N, Kashiwayama Y, Kawano A, Terasawa K, Shimada Y, Ochiai H (2007) Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. Antivir Res 74(1):1–8. https://doi.org/10.1016/j.antiviral.2007.01.003
Hayatgheib N, Fournel C, Calvez S, Pouliquen H, Moreau E (2020) In vitro antimicrobial effect of various commercial essential oils and their chemical constituents on Aeromonas salmonicida subsp. salmonicida. J Appl Microbiol 129(1):137–145. https://doi.org/10.1111/jam.14622
Huang TC, Fu HY, Ho CT, Tan D, Huang YT, Pan MH (2007) Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells. Food Chem 103(2):434–443. https://doi.org/10.1016/j.foodchem.2006.08.018
Hyldgaard M, Mygind T, Meyer RL (2012) Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components. Front Microbiol 3:12. https://doi.org/10.3389/fmicb.2012.00012
Jayaprakasha GK, Singh RP, Pereira J, Sakariah KK (1997) Limonoids from Citrus reticulata and their moult inhibiting activity in mosquito Culex quinquefasciatus larvae. Phytochemistry 44(5):843–846. https://doi.org/10.1016/s0031-9422(96)00589-4
Ji J, Lu C, Kang Y, Wang GX, Chen P (2012) Screening of 42 medicinal plants for in vivo anthelmintic activity against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Parasitol Res 111(1):97–104. https://doi.org/10.1007/s00436-011-2805-6
Jin SE, Jin HE (2019) Synthesis, characterization, and three-dimensional structure generation of zinc oxide-based nanomedicine for biomedical applications. Pharmaceutics 11(11). https://doi.org/10.3390/pharmaceutics11110575
Juven BJ, Kanner J, Schved F, Weisslowicz H (1994) Factors that interact with the antibacterial action of thyme essential oil and its active constituents. J Appl Bacteriol 76(6):626–631. https://doi.org/10.1111/j.1365-2672.1994.tb01661.x
Kanwar R, Rathee J, Salunke DB, Mehta SK (2019) Green nanotechnology-driven drug delivery assemblies. ACS Omega 4(5):8804–8815. https://doi.org/10.1021/acsomega.9b00304
Kaskatepe B, Kiymaci ME, Simsek D, Erol HB, Erdem SA (2016) Comparison of the contents and antimicrobial activities of commercial and natural cinnamon oils. Indian J Pharm Sci 78(4):541–548
Kavyani B, Arabestani MR, Nejad ASM, Moradkhani S, Kamarehei F, Taheri M, Alikhani MY (2019) The effect of cinnamon bark on the expression of quorum sensing system and virulence genes in Pseudomonas aeruginosa strain PAO1. Res J Biotechnol 14(2):42–48. <Go to ISI>://WOS:000456824600006
Kawatra P, Rajagopalan R (2015) Cinnamon: mystic powers of a minute ingredient. Pharm Res 7(Suppl 1):S1–S6. https://doi.org/10.4103/0974-8490.157990
Kitazuru ER, Moreira AVB, Mancini-Filho J, Delincée H, Villavicencio ALCH (2004) Effects of irradiation on natural antioxidants of cinnamon (Cinnamomum zeylanicum N.). Radiat Phys Chem 71(1–2):39–41
Kong JO, Lee SM, Moon YS, Lee SG, Ahn YJ (2007) Nematicidal activity of cassia and cinnamon oil compounds and related compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae). J Nematol 39(1):31–36. https://www.ncbi.nlm.nih.gov/pubmed/19259472
Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R (2010) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer 10:210. https://doi.org/10.1186/1471-2407-10-210
Kothari S, Rajasekar A, Rajeshkumar S (2020) Antimicrobial activity of clove and cinnamon mediated silver nanoparticles against Lactobacillus species - an in vitro study. Plant Cell Biotechnol Mol Biol 21(59–60):1–7
Kumar A, Arvina R, Rajeshkumar S (2020) Antifungal activity of clove and cinnamon mediated selenium nanoparticles: an in vitro study. Plant Cell Biotechnol Mol Biol 21(23–24):18–23
Lee SH, Jun BH (2019) Silver nanoparticles: synthesis and application for nanomedicine. Int J Mol Sci 20(4). https://doi.org/10.3390/ijms20040865
Lee EJ, Kim SR, Kim J, Kim YC (2002) Hepatoprotective phenylpropanoids from Scrophularia buergeriana roots against CCl(4)-induced toxicity: action mechanism and structure-activity relationship. Planta Med 68(5):407–411. https://doi.org/10.1055/s-2002-32081
Lee JE, Jung M, Lee SC, Huh MJ, Seo SM, Park IK (2020) Antibacterial mode of action of trans-cinnamaldehyde derived from cinnamon bark (Cinnamomum verum) essential oil against Agrobacterium tumefaciens. Pestic Biochem Physiol 165:104546. https://doi.org/10.1016/j.pestbp.2020.02.012
Letsididi KS, Lou Z, Letsididi R, Mohammed K, Maguy BL (2018) Antimicrobial and antibiofilm effects of trans-cinnamic acid nanoemulsion and its potential application on lettuce. LWT-Foog Sci Technol 94:25–32
Li Y, Nie Y, Zhou L, Li S, Tang X, Ding Y (2014) The possible mechanism of antifungal activity of cinnamon oil against Rhizopus nigricans. J Chem Pharm Res 6(5):12–20
Li J, Sun Y, Li, C (2015) Volatile oils of Chinese crude medicines exhibit antiparasitic activity against human Demodex with no adverse effects in vivo. Exp Ther Med 9(4):1304–1308
Liao C, Li Y, Tjong SC (2019) Bactericidal and cytotoxic properties of silver nanoparticles. Int J Mol Sci 20(2). https://doi.org/10.3390/ijms20020449
Ling F, Jiang C, Liu G, Li M, Wang G (2015) Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius. Parasitology 142(14):1744–1750. https://doi.org/10.1017/S0031182015001031
Liu JX, Sun YH, Li CP (2015) Volatile oils of Chinese crude medicines exhibit antiparasitic activity against human Demodex with no adverse effects in vivo. Exp Ther Med 9(4):1304–1308. https://doi.org/10.3892/etm.2015.2272
Lu Z, Jia Q, Wang R, Wu X, Wu Y, Huang C, Li Y (2011) Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different cinnamon barks. Phytomedicine 18(4):298–302. https://doi.org/10.1016/j.phymed.2010.08.008
Mamatha G, Varada Rajulu A, Madhukar K (2019) Development and analysis of cellulose nanocomposite films with in situ generated silver nanoparticles using tamarind nut powder as a reducing agent. Int J Polym Anal Charact 24(3):219–226. https://doi.org/10.1080/1023666X.2018.1564572
Marcoux E, Lagha AB, Gauthier P, Grenier D (2020) Antimicrobial activities of natural plant compounds against endodontic pathogens and biocompatibility with human gingival fibroblasts. Arch Oral Biol 116:104734. https://doi.org/10.1016/j.archoralbio.2020.104734
Mathew S, Abraham TE (2006) Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chem 94(4):520–528. https://doi.org/10.1016/j.foodchem.2004.11.043
Melo AD, Amaral AF, Schaefer G, Luciano FB, de Andrade C, Costa LB, Rostagno MH (2015) Antimicrobial effect against different bacterial strains and bacterial adaptation to essential oils used as feed additives. Can J Vet Res 79(4):285–289. https://www.ncbi.nlm.nih.gov/pubmed/26424908
Mishra P, Gupta P, Pruthi V (2021) Cinnamaldehyde incorporated gellan/PVA electrospun nanofibers for eradicating Candida biofilm. Mater Sci Eng C Mater Biol Appl 119:111450. https://doi.org/10.1016/j.msec.2020.111450
Mohammad P, Zienab B, Hossein KJ (2014) The effect of cinnamon extract on gonadotrop in changes (FSH & LH) in rats treated with gelophen. Biomed Pharmacol J 7(1):363–367. https://doi.org/10.13005/bpj/499
Muchuweti M, Kativu E, Mupure CH, Chidewe C, Ndhlala AR, Benhura MAN (2007) Phenolic composition and antioxidant properties of some spices. Am J Food Technol 2(5):414–420
Nabavi SF, Di Lorenzo A, Izadi M, Sobarzo-Sanchez E, Daglia M, Nabavi SM (2015) Antibacterial effects of cinnamon: from farm to food, cosmetic and pharmaceutical industries. Nutrients 7(9):7729–7748. https://doi.org/10.3390/nu7095359
Nagarajan K, Rajasekar A, Rajeshkumar S (2020) Antimicrobial activity of clove and cinnamon formulation mediated selenium nanoparticles against oral pathogens. Plant Cell Biotechnol Mol Biol 21(31–32):27–35
Nazzaro F, Fratianni F, De Martino L, Coppola R, De Feo V (2013) Effect of essential oils on pathogenic bacteria. Pharmaceuticals (Basel) 6(12):1451–1474. https://doi.org/10.3390/ph6121451
Nir Y, Potasman I, Stermer E, Tabak M, Neeman I (2000) Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter 5(2):94–97. https://doi.org/10.1046/j.1523-5378.2000.00014.x
Ose R, Tu J, Schink A, Maxeiner J, Schuster P, Lucas K, Saloga J, Bellinghausen I (2020) Cinnamon extract inhibits allergen-specific immune responses in human and murine allergy models. Clin Exp Allergy 50(1):41–50. https://doi.org/10.1111/cea.13507
Parvazi S, Sadeghi S, Azadi M, Mohammadi M, Arjmand M, Vahabi F, Sadeghzadeh S, Zamani Z (2016) The effect of aqueous extract of cinnamon on the metabolome of Plasmodium falciparum using (1)HNMR spectroscopy. J Trop Med 2016:3174841. https://doi.org/10.1155/2016/3174841
Polansky H, Lori G (2020) Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 infection. Int J Antimicrob Agents 55(6):105971. https://doi.org/10.1016/j.ijantimicag.2020.105971
Potrč S, Fras Zemljič L, Sterniša M, Smole Možina S, Plohl O (2020) Development of biodegradable whey-based laminate functionalised by chitosan–natural extract formulations. Int J Mol Sci 21(10):3668. https://www.mdpi.com/1422-0067/21/10/3668
Prasanth D, Murahari M, Chandramohan V, Panda SP, Atmakuri LR, Guntupalli C (2020) In silico identification of potential inhibitors from cinnamon against main protease and spike glycoprotein of SARS CoV-2. J Biomol Struct Dyn:1–15. https://doi.org/10.1080/07391102.2020.1779129
Premkumar J, Sudhakar T, Dhakal A, Shrestha JB, Krishnakumar S, Balashanmugam P (2018) Synthesis of silver nanoparticles (AgNPs) from cinnamon against bacterial pathogens. Biocatal Agric Biotechnol 15:311–316
Purkait S, Bhattacharya A, Bag A, Chattopadhyay RR (2020) Synergistic antibacterial, antifungal and antioxidant efficacy of cinnamon and clove essential oils in combination. Arch Microbiol 202(6):1439–1448. https://doi.org/10.1007/s00203-020-01858-3
Qi G, Chen J, Chen G, Yang Z, Wang H, Wang S (2018) Inhibition of biofilm formation in Pseudomonas aeruginosa by cinnamon extract. J Food Sci Biotechnol 37(8):807–811. https://doi.org/10.3969/j.issn.1673-1689.2018.08.004
Quale JM, Landman D, Zaman MM, Burney S, Sathe SS (1996) In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis. Am J Chin Med 24(2):103–109. https://doi.org/10.1142/S0192415X96000153
Ranasinghe P, Jayawardena R, Galappaththy P, Constantine GR, de Vas Gunawardana N, Katulanda P (2013) Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 30(4):506–507. https://doi.org/10.1111/dme.12141
Ranasinghe P, Jayawardena R, Pigera S, Wathurapatha WS, Weeratunga HD, Premakumara GAS, Katulanda P, Constantine GR, Galappaththy P (2017) Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 17(1):550. https://doi.org/10.1186/s12906-017-2067-7
Reda M, Ashames A, Edis Z, Bloukh S, Bhandare R, Abu Sara H (2019) Green synthesis of potent antimicrobial silver nanoparticles using different plant extracts and their mixtures. PRO 7(8):510. https://www.mdpi.com/2227-9717/7/8/510
Ren JL, Zhang AH, Wang XJ (2020) Traditional Chinese medicine for COVID-19 treatment. Pharmacol Res 155:104743. https://doi.org/10.1016/j.phrs.2020.104743
Riau AK, Aung TT, Setiawan M, Yang L, Yam GHF, Beuerman RW, Venkatraman SS, Mehta JS (2019) Surface immobilization of nano-silver on polymeric medical devices to prevent bacterial biofilm formation. Pathogens 8(3). https://doi.org/10.3390/pathogens8030093
Saki M, Seyed Mohammadi S, Montazeri EA, Siahpoosh A, Moosavian M, Latifi SM (2020) In vitro antibacterial properties of Cinnamomum zeylanicum essential oil against clinical extensively drug-resistant bacteria. Eur J Integr Med 37:101146
Sakkas H, Bozidis P, Ilia A, Mpekoulis G, Papadopoulou C (2019) Antimicrobial resistance in bacterial pathogens and detection of carbapenemases in klebsiella pneumoniae isolates from hospital wastewater. Antibiotics 8(3). https://doi.org/10.3390/antibiotics8030085
Sangal A (2011) Role of cinnamon as beneficial antidiabetic food adjunct : a review. Adv Appl Sci Res 2(4):440–450
Shah A, Ali Buabeid M, Arafa EA, Hussain I, Li L, Murtaza G (2019) The wound healing and antibacterial potential of triple-component nanocomposite (chitosan-silver-sericin) films loaded with moxifloxacin. Int J Pharm 564:22–38. https://doi.org/10.1016/j.ijpharm.2019.04.046
Shah A, Ashames AA, Buabeid MA, Murtaza G (2020) Synthesis, in vitro characterization and antibacterial efficacy of moxifloxacin-loaded chitosan-pullulan-silver-nanocomposite films. J Drug Deliv Sci Technol 55:101366
Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES (2018) Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. Fungal Biol Biotechnol 5:3. https://doi.org/10.1186/s40694-018-0046-5
Sharma S (2015) Food preservatives and their harmfull effect. Int J Sci Res Publ 5(4):5–6. http://www.ijsrp.org/research-paper-0415/ijsrp-p4014.pdf
Sheng L, Rasco B, Zhu MJ (2016) Cinnamon oil inhibits Shiga toxin type 2 phage induction and Shiga toxin type 2 production in Escherichia coli O157:H7. Appl Environ Microbiol 82(22):6531–6540. https://doi.org/10.1128/AEM.01702-16
Shin JM, Luo T, Lee KH, Guerreiro D, Botero TM, McDonald NJ, Rickard AH (2018) Deciphering endodontic microbial communities by next-generation sequencing. J Endod 44(7):1080–1087. https://doi.org/10.1016/j.joen.2018.04.003
Smith CK, Moore CA, Elahi EN, Smart AT, Hotchkiss SA (2000) Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol. Toxicol Appl Pharmacol 168(3):189–199. https://doi.org/10.1006/taap.2000.9025
Somrani M, Ingles MC, Debbabi H, Abidi F, Palop A (2020) Garlic, onion, and cinnamon essential oil anti-biofilms' effect against Listeria monocytogenes. Foods 9(5). https://doi.org/10.3390/foods9050567
Swamy MK, Sinniah UR (2015) A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth.: an aromatic medicinal plant of industrial importance. Molecules 20(5):8521–8547. https://doi.org/10.3390/molecules20058521
Swamy KM, Neeki MA, Bhaumik SH, Darshil SH, Vijay R, Kashyap S (2012) Phytochemical screening and in vitro antimicrobial activity of Bougainvillea spectabilis flower extracts. Int J Phytomed 4:375–379
Tanker M, Tanker N (1990) Pharmacognosy. Ankara University, Ankara
Tavares TD, Antunes JC, Padrao J, Ribeiro AI, Zille A, Amorim MTP, Ferreira F, Felgueiras HP (2020) Activity of specialized biomolecules against gram-positive and gram-negative bacteria. Antibiotics (Basel) 9(6). https://doi.org/10.3390/antibiotics9060314
Tung YT, Chua MT, Wang SY, Chang ST (2008) Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour Technol 99(9):3908–3913. https://doi.org/10.1016/j.biortech.2007.07.050
Tung YT, Yen PL, Lin CY, Chang ST (2010) Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharm Biol 48(10):1130–1136. https://doi.org/10.3109/13880200903527728
Utchariyakiat I, Surassmo S, Jaturanpinyo M, Khuntayaporn P, Chomnawang MT (2016) Efficacy of cinnamon bark oil and cinnamaldehyde on anti-multidrug resistant Pseudomonas aeruginosa and the synergistic effects in combination with other antimicrobial agents. BMC Complement Altern Med 16:158. https://doi.org/10.1186/s12906-016-1134-9
Uzair B, Niaz N, Bano A, Khan BA, Zafar N, Iqbal M, Tahira R, Fasim F (2017) Essential oils showing in vitro anti MRSA and synergistic activity with penicillin group of antibiotics. Pak J Pharm Sci 30(5(Supplementary)):1997–2002. https://www.ncbi.nlm.nih.gov/pubmed/29105634
Vasconcelos NG, Croda J, Simionatto S (2018) Antibacterial mechanisms of cinnamon and its constituents: a review. Microb Pathog 120:198–203. https://doi.org/10.1016/j.micpath.2018.04.036
Wang SY, Chen PF, Chang ST (2005) Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophloeum) leaves against wood decay fungi. Bioresour Technol 96(7):813–818. https://doi.org/10.1016/j.biortech.2004.07.010
Wang A, Bi Y, Wen X, Wang Y, Cai H (2020) Antifungal activity of 4 kinds of aromatic essential oil derived from plants to pathogenic fungi of bamboo. Sci Silvae Sin 56(6):59–67. https://doi.org/10.11707/j.1001-7488.20200606
Weibel H, Hansen J (1989) Interaction of cinnamaldehyde (a sensitizer in fragrance) with protein. Contact Dermatitis 20(3):161–166. https://doi.org/10.1111/j.1600-0536.1989.tb04650.x
WHO (2002) Evaluation of certain food additives and contaminants (World Health Organization Technical Report Series). Issue
WHO (2017) One health. https://www.who.int/news-room/q-a-detail/one-health
Wiesner J, Mitsch A, Wissner P, Jomaa H, Schlitzer M (2001) Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives. Bioorg Med Chem Lett 11(3):423–424. https://doi.org/10.1016/s0960-894x(00)00684-3
Willoughby MJ, Mills S (1996) British herbal pharmacopoeia, 4th edn. British Herbal Medicine Association, London
Yap PSX, Lim SHE, Hu CP, Yiap BC (2013) Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria. Phytomedicine 20(8–9):710–713. https://doi.org/10.1016/j.phymed.2013.02.013
Yap PS, Krishnan T, Chan KG, Lim SH (2015) Antibacterial mode of action of Cinnamomum verum bark essential oil, alone and in combination with Piperacillin, against a multi-drug-resistant Escherichia coli strain. J Microbiol Biotechnol 25(8):1299–1306. https://doi.org/10.4014/jmb.1407.07054
Yuan JH, Dieter MP, Bucher JR, Jameson CW (1992) Toxicokinetics of cinnamaldehyde in F344 rats. Food Chem Toxicol 30(12):997–1004. https://doi.org/10.1016/0278-6915(92)90109-x
Zhang Y, Liu X, Wang Y, Jiang P, Quek S (2016) Antibacterial activity and mechanism of cinnamon essential oil against Escherichia coli and Staphylococcus aureus. Food Control 59:282–289. https://doi.org/10.1016/j.foodcont.2015.05.032
Zhuang M, Jiang H, Suzuki Y, Li X, Xiao P, Tanaka T, Ling H, Yang B, Saitoh H, Zhang L, Qin C, Sugamura K, Hattori T (2009) Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antivir Res 82(1):73–81. https://doi.org/10.1016/j.antiviral.2009.02.001
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Kiymaci, M.E., Kaskatepe, B. (2022). Assessment of Cinnamon as an Antimicrobial Agent. In: Rai, M., Kosalec, I. (eds) Promising Antimicrobials from Natural Products. Springer, Cham. https://doi.org/10.1007/978-3-030-83504-0_4
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