Abstract
In this chapter the different methods for the analysis of data from an n-of-1 trial are discussed. Although there are many different ways in which an n-of-1 trial can be performed, in general there are many repeated measurements within one subject. In these repeated measurements, the subject receives either the intervention or the control condition or, for instance, different forms of the intervention (e.g., different doses of medication). When there is a true n-of-1 trial performed, the best way to “estimate” an intervention effect is descriptive statistics. However, mostly, a series of n-of-1 trials is performed. In this chapter a few examples are given in which a series of n-of-1 trials can be analyzed and how an appropriate intervention effect can be estimated.
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References
Box, G. E. P., & Jenkins, G. M. (1994). Time series analysis, forecasting and control (3rd ed.). Prentice Hall.
Chen, X., & Chen, P. (2014). A comparison of four methods for the analysis of N-of-1 trials. PLoS ONE, 9(2), e87752. https://doi.org/10.1371/journal.pone.0087752
Lillie, E. O., Patay, B., Diamant, J., Issell, B., Topol, E. J., & Schork, N. J. (2011). The n-of-1 clinical trial: The ultimate strategy for individualizing medicine? Personalized Medicine, 8, 161–173.
McCleary, R., & Hay, R. A. (1980). Applied time series analysis for the social sciences. Sage.
Peixeiro, M., (2019). The complete guide to time series analysis and forecasting understand moving average, exponential smoothing, stationarity, autocorrelation, SARIMA, and apply these techniques in two projects. https://towardsdatascience.com/
Wei, W.S. (2013). Time series analysis. https://www.oxfordhandbooks.com/
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Twisk, J.W.R. (2021). Analysis of Data from an N-of-1 Trial. In: Analysis of Data from Randomized Controlled Trials. Springer, Cham. https://doi.org/10.1007/978-3-030-81865-4_7
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DOI: https://doi.org/10.1007/978-3-030-81865-4_7
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