Abstract
In a prebiotic world, the first form of cells, the protocells, were able to incorporate functional molecules such as polymers with self-replicative properties thanks to primitive forms of membranes. Lipid boundaries represent the chemico-physical barrier between the inner and the outer part of a modern cellular environment. However, one could expect that other types of boundaries were present in primitive compartments. In this chapter we present a prebiotic chemistry perspective that includes the synthesis of amphiphiles under prebiotic conditions, their role in protocells boundary formation and how synthetic protocells were assembled to simulate plausible.
In memory of Océane
Carolina Chieffo and Augustin Lopez contributed equally.
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References
Adamala, K., Szostak, J.W.: Nonenzymatic template-directed RNA synthesis inside model protocells. Science. 342, 1098–1100 (2013). https://doi.org/10.1126/science.1241888
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P.: Molecular Biology of the Cell. Garland Science, New York (2014)
Albertsen, A.N., Duffy, C.D.D., Sutherland, J.D.D., Monnard, P.-A.A.: Self-assembly of phosphate Amphiphiles in mixtures of prebiotically plausible surfactants. Astrobiology. 14, 462–472 (2014). https://doi.org/10.1089/ast.2013.1111
Apel, C.L., Deamer, D.W., Mautner, M.N.: Self-assembled vesicles of monocarboxylic acids and alcohols: conditions for stability and for the encapsulation of biopolymers. Biochim. Biophys. Acta Biomembr. 1559, 1–9 (2002). https://doi.org/10.1016/S0005-2736(01)00400-X
Berclaz, N., Müller, M., Walde, P., Luisi, P.L.: Growth and transformation of vesicles studied by ferritin labeling and cryotransmission electron microscopy. J. Phys. Chem. B. 105, 1056–1064 (2001). https://doi.org/10.1021/jp001298i
Betts, H.C., Puttick, M.N., Clark, J.W., et al.: Integrated genomic and fossil evidence illuminates life’s early evolution and eukaryote origin. Nat. Ecol. Evol. 2, 1556–1562 (2018). https://doi.org/10.1038/s41559-018-0644-x
Black, R., Blosser, M.: A self-assembled aggregate composed of a fatty acid membrane and the building blocks of biological polymers provides a first step in the emergence of protocells. Life. 6, 33 (2016). https://doi.org/10.3390/life6030033
Black, R.A., Blosser, M.C., Stottrup, B.L., et al.: Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells. Proc. Natl. Acad. Sci. 110, 13272–13276 (2013). https://doi.org/10.1073/pnas.1300963110
Blain, J.C., Szostak, J.W.: Progress toward synthetic cells. Annu. Rev. Biochem. 83, 615–640 (2014). https://doi.org/10.1146/annurev-biochem-080411-124036
Bonfio, C., Caumes, C., Duffy, C.D., et al.: Length-selective synthesis of acylglycerol-phosphates through energy-dissipative cycling. J. Am. Chem. Soc. 141, 3934–3939 (2019). https://doi.org/10.1021/jacs.8b12331
Božič, B., Svetina, S.: A relationship between membrane properties forms the basis of a selectivity mechanism for vesicle self-reproduction. Eur. Biophys. J. 33, 565–571 (2004). https://doi.org/10.1007/s00249-004-0404-5
Budin, I., Szostak, J.W.: Physical effects underlying the transition from primitive to modern cell membranes. Proc. Natl. Acad. Sci. 108, 5249–5254 (2011). https://doi.org/10.1073/pnas.1100498108
Cape, J.L., Monnard, P.-A., Boncella, J.M.: Prebiotically relevant mixed fatty acid vesicles support anionic solute encapsulation and photochemically catalyzed trans-membrane charge transport. Chem. Sci. 2, 661 (2011). https://doi.org/10.1039/c0sc00575d
Chandru, K., Mamajanov, I., Cleaves, H.J., Jia, T.Z.: Polyesters as a model system for building primitive biologies from non-biological prebiotic chemistry. Life. 10 (2020). https://doi.org/10.3390/life10010006
Chen, I.A., Szostak, J.W.: Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc. Natl. Acad. Sci. USA. 101, 7965–7970 (2004). https://doi.org/10.1073/pnas.0308045101
Chen, I.A., Walde, P.: From self-assembled vesicles to protocells. Cold Spring Harb. Perspect. Biol. 2, a002170 (2010). https://doi.org/10.1101/cshperspect.a002170
Chen, I.A., Salehi-Ashtiani, K., Szostak, J.W.: RNA catalysis in model protocell vesicles. J. Am. Chem. Soc. 127, 13213–13219 (2005). https://doi.org/10.1021/ja051784p
Chyba, C., Sagan, C.: Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: an inventory for the origins of life. Nature. 355, 125–132 (1992). https://doi.org/10.1038/355125a0
Cornell, C.E., Black, R.A., Xue, M., et al.: Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes. Proc. Natl. Acad. Sci. USA. 116, 17239–17244 (2019a). https://doi.org/10.1073/pnas.1900275116
Cornell, C.E., Black, R.A., Xue, M., et al.: Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes. Proc. Natl. Acad. Sci. 116, 17239–17244 (2019b). https://doi.org/10.1073/pnas.1900275116
Damer, B., Deamer, D.: Coupled phases and combinatorial selection in fluctuating hydrothermal pools: a scenario to guide experimental approaches to the origin of cellular life. Life. 5, 872–887 (2015). https://doi.org/10.3390/life5010872
Danger, G., D’Hendecourt, L.L.S., Pascal, R.: On the conditions for mimicking natural selection in chemical systems. Nat. Rev. Chem. 4, 102–109 (2020). https://doi.org/10.1038/s41570-019-0155-6
Deamer, D.W.: Boundary structures are formed by organic components of the Murchison carbonaceous chondrite. Nature. 317, 792–794 (1985). https://doi.org/10.1038/317792a0
Deamer, D.: The role of lipid membranes in life’s origin. Life. 7, 5 (2017). https://doi.org/10.3390/life7010005
Drobot, B., Iglesias-Artola, J.M., Le Vay, K., et al.: Compartmentalised RNA catalysis in membrane-free coacervate protocells. Nat. Commun. 9, 1–9 (2018). https://doi.org/10.1038/s41467-018-06072-w
Eichberg, J., Sherwood, E., Epps, D.E., Oró, J.: Cyanamide mediated syntheses under plausible primitive earth conditions. J. Mol. Evol. 10, 221–230 (1977). https://doi.org/10.1007/BF01764597
Epps, D.E., Sherwood, E., Eichberg, J., Or, J.: Cyanamide mediated syntheses under plausible primitive earth conditions: V. The synthesis of phosphatidic acids. J. Mol. Evol. 11, 279–292 (1978)
Epps, D.E., Nooner, D.W., Eichberg, J., et al.: Cyanamide mediated synthesis under plausible primitive earth conditions: VI. The synthesis of glycerol and glycerophosphates. J. Mol. Evol. 14, 235–241 (1979). https://doi.org/10.1007/BF01732490
Fayolle, D., Altamura, E., D’Onofrio, A., et al.: Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments. Sci. Rep. 7, 18106 (2017). https://doi.org/10.1038/s41598-017-18053-y
Fiore, M.: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions. Org. Biomol. Chem. 16, 3068–3086 (2018). https://doi.org/10.1039/C8OB00469B
Fiore, M., Strazewski, P.: Prebiotic lipidic amphiphiles and condensing agents on the early earth. Life. 6, 17 (2016). https://doi.org/10.3390/life6020017
Fiore, M., Madanamoothoo, W., Berlioz-Barbier, A., et al.: Giant vesicles from rehydrated crude mixtures containing unexpected mixtures of amphiphiles formed under plausibly prebiotic conditions. Org. Biomol. Chem. 15, 4231–4240 (2017). https://doi.org/10.1039/C7OB00708F
Gibard, C., Bhowmik, S., Karki, M., et al.: Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions. Nat. Chem. 10, 212–217 (2018). https://doi.org/10.1038/nchem.2878
Groen, J., Deamer, D.W., Kros, A., Ehrenfreund, P.: Polycyclic aromatic hydrocarbons as plausible prebiotic membrane components. Origin Life Evol. Biosph. 42, 295–306 (2012). https://doi.org/10.1007/s11084-012-9292-3
Grommet, A.B., Feller, M., Klajn, R.: Chemical reactivity under nanoconfinement. Nat. Nanotechnol. 15, 256–271 (2020). https://doi.org/10.1038/s41565-020-0652-2
Hanczyc, M.M., Monnard, P.-A.A.: Primordial membranes: more than simple container boundaries. Curr. Opin. Chem. Biol. 40, 78–86 (2017). https://doi.org/10.1016/j.cbpa.2017.07.009
Hanczyc, M.M., Fujikawa, S.M., Szostak, J.W.: Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science. 302, 618–622 (2003). https://doi.org/10.1126/science.1089904
Hanczyc, M.M., Mansy, S.S., Szostak, J.W.: Mineral surface directed membrane assembly. Orig. Life Evol. Biosph. 37, 67–82 (2007). https://doi.org/10.1007/s11084-006-9018-5
Hansma, H.: Better than membranes at the origin of life? Life. 7, 28 (2017). https://doi.org/10.3390/life7020028
Hargreaves, W.R., Deamer, D.W.: Liposomes from ionic, single-chain Amphiphiles. Biochemistry. 17, 3759–3768 (1978). https://doi.org/10.1021/bi00611a014
Hargreaves, W.R., Mulvil, S.J., Deamer, D.W.: Synthesis of phospholipids and membranes in prebiotic conditions. Nature. 266, 78–80 (1977). https://doi.org/10.1038/266078a0
Hazen, R.M., Sverjensky, D.A.: Mineral surfaces, geochemical complexities, and the origins of life. Cold Spring Harb. Perspect. Biol. 2, a002162–a002162 (2010). https://doi.org/10.1101/cshperspect.a002162
Huang, Y., Wang, Y., Alexandre, M.R., et al.: Molecular and compound-specific isotopic characterization of monocarboxylic acids in carbonaceous meteorites. Geochim. Cosmochim. Acta. 69, 1073–1084 (2005). https://doi.org/10.1016/j.gca.2004.07.030
Isaad, A.L.C., Carrara, P., Stano, P., et al.: A hydrophobic disordered peptide spontaneously anchors a covalently bound RNA hairpin to giant lipidic vesicles. Org. Biomol. Chem. 12, 6363–6373 (2014). https://doi.org/10.1039/c4ob00721b
IUPAC-IUB Commission on Biochemical Nomenclature: The nomenclature of lipids (recommendations 1976). J. Lipid. Res. 19, 114–128 (1978)
Izgu, E.C., Björkbom, A., Kamat, N.P., et al.: N-Carboxyanhydride-mediated fatty acylation of amino acids and peptides for functionalization of protocell membranes. J. Am. Chem. Soc. 138, 16669–16676 (2016). https://doi.org/10.1021/jacs.6b08801
Javaux, E.J.: Challenges in evidencing the earliest traces of life. Nature. 572, 451–460 (2019). https://doi.org/10.1038/s41586-019-1436-4
Jia, T.Z., Chandru, K., Hongo, Y., et al.: Membraneless polyester microdroplets as primordial compartments at the origins of life. Proc. Natl. Acad. Sci. 116, 15830–15835 (2019). https://doi.org/10.1073/pnas.1902336116
Jin, L., Kamat, N.P., Jena, S., Szostak, J.W.: Fatty acid/phospholipid blended membranes: a potential intermediate state in protocellular evolution. Small. 14, 1–9 (2018). https://doi.org/10.1002/smll.201704077
Jordan, S.F., Rammu, H., Zheludev, I.N., et al.: Promotion of protocell self-assembly from mixed amphiphiles at the origin of life. Nat. Ecol. Evol. 3, 1705–1714 (2019). https://doi.org/10.1038/s41559-019-1015-y
Joyce, G.F., Szostak, J.W.: Protocells and RNA self-replication. Cold Spring Harb. Perspect. Biol. 10 (2018). https://doi.org/10.1101/cshperspect.a034801
Kamat, N.P., Tobé, S., Hill, I.T., Szostak, J.W.: Electrostatic localization of RNA to protocell membranes by cationic hydrophobic peptides. Angew. Chem. Int. Ed. 54, 11735–11739 (2015). https://doi.org/10.1002/anie.201505742
Kee, T.P., Monnard, P.-A.A.: Chemical systems, chemical contiguity and the emergence of life. Beilstein J. Org. Chem. 13, 1551–1563 (2017). https://doi.org/10.3762/bjoc.13.155
Kitadai, N., Maruyama, S.: Origins of building blocks of life: a review. Geosci. Front. 9, 1117–1153 (2018). https://doi.org/10.1016/j.gsf.2017.07.007
Klein, A.E., Pilpel, N.: Oxidation of n-alkanes photosensitized by 1-naphthol. J. Chem. Soc. Faraday Trans. 1 Phys. Chem. Condens. Phases. 69, 1729 (1973). https://doi.org/10.1039/f19736901729
Koga, S., Williams, D.S., Perriman, A.W., Mann, S.: Peptide-nucleotide microdroplets as a step towards a membrane-free protocell model. Nat. Chem. 3, 720–724 (2011). https://doi.org/10.1038/nchem.1110
Lee, D.H., Granja, J.R., Martinez, J.A., et al.: A self-replicating peptide. Nature. 382, 525–528 (1996). https://doi.org/10.1038/382525a0
Lombard, J., López-García, P., Moreira, D.: The early evolution of lipid membranes and the three domains of life. Nat. Rev. Microbiol. 10, 507–515 (2012). https://doi.org/10.1038/nrmicro2815
Lonchin, S., Luisi, P.L., Walde, P., Robinson, B.H.: A matrix effect in mixed phospholipid/fatty acid vesicle formation. J. Phys. Chem. B. 103, 10910–10916 (1999). https://doi.org/10.1021/jp9909614
Lopez, A., Fiore, M.: Investigating prebiotic protocells for a comprehensive understanding of the origins of life: a prebiotic systems chemistry perspective. Life. 9, 1–21 (2019). https://doi.org/10.3390/life9020049
Ma, W., Feng, Y.: Protocells: at the interface of life and non-life. Life. 5, 447–458 (2015). https://doi.org/10.3390/life5010447
Mansy, S.S.: Membrane transport in primitive cells. Cold Spring Harb. Perspect. Biol. 2, 1–14 (2010). https://doi.org/10.1101/cshperspect.a002188
Mansy, S.S., Szostak, J.W.: Thermostability of model protocell membranes. Proc. Natl. Acad. Sci. 105, 13351–13355 (2008). https://doi.org/10.1073/pnas.0805086105
Mansy, S.S., Schrum, J.P., Krishnamurthy, M., et al.: Template-directed synthesis of a genetic polymer in a model protocell. Nature. 454, 122–125 (2008). https://doi.org/10.1038/nature07018
Mariscal, C., Barahona, A., Aubert-Kato, N., et al.: Hidden concepts in the history and philosophy of origins-of-life studies: a workshop report. Origin Life Evol. Biosph. 49, 111–145 (2019). https://doi.org/10.1007/s11084-019-09580-x
Maurer, S.E., Nguyen, G.: Prebiotic vesicle formation and the necessity of salts. Orig Life Evol. Biosph. 46, 215–222 (2016). https://doi.org/10.1007/s11084-015-9476-8
Maurer, S.E., Deamer, D.W., Boncella, J.M., Monnard, P.A.: Chemical evolution of amphiphiles: glycerol monoacyl derivatives stabilize plausible prebiotic membranes. Astrobiology. 9, 979–987 (2009). https://doi.org/10.1089/ast.2009.0384
Mccollom, T.M., Simoneit, B.R.T.: Abiotic formation of hydrocarbons and oxygenated compounds during thermal decomposition of iron oxalate. Orig. Life Evol. Biosph. 29, 167–186 (1999). https://doi.org/10.1023/A:1006556315895
Mccollom, T.M., Ritter, G., Simoneit, B.R.T.: Lipid synthesis under hydrothermal conditions by Fischer-Tropsch-type reactions. Orig. Life Evol. Biosph. 29, 153–166 (1999). https://doi.org/10.1023/A:1006592502746
Monnard, P.A., Deamer, D.W.: Preparation of vesicles from nonphospholipid amphiphiles. Methods Enzymol. 372, 133–151 (2003). https://doi.org/10.1016/S0076-6879(03)72008-4
Monnard, P.-A.A., Walde, P.: Current ideas about prebiological compartmentalization. Life. 5, 1239–1263 (2015). https://doi.org/10.3390/life5021239
Monnard, P.-A., Apel, C.L., Kanavarioti, A., Deamer, D.W.: Influence of ionic inorganic solutes on self-assembly and polymerization processes related to early forms of life: implications for a prebiotic aqueous medium. Astrobiology. 2, 139–152 (2002). https://doi.org/10.1089/15311070260192237
Morigaki, K., Dallavalle, S., Walde, P., et al.: Autopoietic self-reproduction of chiral fatty acid vesicles. J. Am. Chem. Soc. 119, 292–301 (1997). https://doi.org/10.1021/ja961728b
Murillo-Sánchez, S., Beaufils, D., González Mañas, J.M., et al.: Fatty acids’ double role in the prebiotic formation of a hydrophobic dipeptide. Chem. Sci. 7, 3406–3413 (2016). https://doi.org/10.1039/c5sc04796j
Namani, T., Ishikawa, T., Morigaki, K., Walde, P.: Vesicles from docosahexaenoic acid. Colloids Surf. B Biointerfaces. 54, 118–123 (2007). https://doi.org/10.1016/j.colsurfb.2006.05.022
Ourisson, G., Nakatani, Y.: The terpenoid theory of the origin of cellular life: the evolution of terpenoids to cholesterol. Chem. Biol. 1, 11–23 (1994). https://doi.org/10.1016/1074-5521(94)90036-1
Paltauf, F., Hermetter, A.: Strategies for the synthesis of glycerophospholipids. Prog. Lipid Res. 33, 239–328 (1994). https://doi.org/10.1016/0163-7827(94)90028-0
Patel, B.H., Percivalle, C., Ritson, D.J., et al.: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism. Nat. Chem. 7, 301–307 (2015). https://doi.org/10.1038/nchem.2202
Paula, S., Volkov, A.G., Van Hoek, A.N., et al.: Permeation of protons, potassium ions, and small polar molecules through phospholipid bilayers as a function of membrane thickness. Biophys. J. 70, 339–348 (1996). https://doi.org/10.1016/S0006-3495(96)79575-9
Peretó, J., López-García, P., Moreira, D.: Ancestral lipid biosynthesis and early membrane evolution. Trends Biochem. Sci. 29, 469–477 (2004). https://doi.org/10.1016/j.tibs.2004.07.002
Pfeiffer, I., Höök, F.: Bivalent cholesterol-based coupling of oligonucletides to lipid membrane assemblies. J. Am. Chem. Soc. 126, 10224–10225 (2004). https://doi.org/10.1021/ja048514b
Pizzarello, S., Shock, E.: The organic composition of carbonaceous meteorites: the evolutionary story ahead of biochemistry. Cold Spring Harb. Perspect. Biol. 2, a002105–a002105 (2010). https://doi.org/10.1101/cshperspect.a002105
Powner, M.W., Sutherland, J.D.: Prebiotic chemistry: a new modus operandi. Philos. Trans. R. Soc. B. Biol. Sci. 366, 2870–2877 (2011). https://doi.org/10.1098/rstb.2011.0134
Qiao, H., Hu, N., Bai, J., et al.: Encapsulation of nucleic acids into giant unilamellar vesicles by freeze-thaw: a way protocells may form. Origin Life Evol. Biosph. 47, 499–510 (2017). https://doi.org/10.1007/s11084-016-9527-9
Rao, M., Eichberg, J., Oró, J.: Synthesis of phosphatidylcholine under possible primitive Earth conditions. J. Mol. Evol. 18, 196–202 (1982). https://doi.org/10.1007/BF01733046
Rao, M., Eichberg, J., Oró, J.: Synthesis of phosphatidylethanolamine under possible primitive earth conditions. J. Mol. Evol. 25, 1–6 (1987). https://doi.org/10.1007/BF02100033
Reeves, J.P., Dowben, R.M.: Formation and properties of thin-walled phospholipid vesicles. J. Cell. Physiol. 73, 49–60 (1969). https://doi.org/10.1002/jcp.1040730108
Ruiz-Mirazo, K., Briones, C., De La Escosura, A.: Prebiotic systems chemistry: new perspectives for the origins of life. Chem. Rev. 114, 285–366 (2014). https://doi.org/10.1021/cr2004844
Ruiz-Mirazo, K., Briones, C., de la Escosura, A.: Chemical roots of biological evolution: the origins of life as a process of development of autonomous functional systems. Open Biol. 7, 170050 (2017). https://doi.org/10.1098/rsob.170050
Rushdi, A.I., Simoneit, B.R.T.T.: Abiotic condensation synthesis of glyceride lipids and wax esters under simulated hydrothermal conditions. Origin Life Evol. Biosph. 36, 93–108 (2006). https://doi.org/10.1007/s11084-005-9001-6
Sacerdote, M.G., Szostak, J.W.: Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Proc. Natl. Acad. Sci. U. S. A. 102, 6004–6008 (2005). https://doi.org/10.1073/pnas.0408440102
Saladino, R., Crestini, C., Pino, S., et al.: Formamide and the origin of life. Phys. Life Rev. 9, 84–104 (2012). https://doi.org/10.1016/j.plrev.2011.12.002
Segre, D., Ben-Eli, D., Lancet, D.: Compositional genomes: prebiotic information transfer in mutually catalytic noncovalent assemblies. Proc. Natl. Acad. Sci. 97, 4112–4117 (2000). https://doi.org/10.1073/pnas.97.8.4112
Shirt-Ediss, B., Murillo-Sánchez, S., Ruiz-Mirazo, K.: Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research. Beilstein J. Org. Chem. 13, 1388–1395 (2017). https://doi.org/10.3762/bjoc.13.135
Simionescu, C.I., Dénes, F., Totolin, M.: The synthesis of some lipid-like structures in simulated primeval earth conditions. Biosystems. 13, 149–156 (1981). https://doi.org/10.1016/0303-2647(81)90056-3
Simoneit, B.R.T.: Prebiotic organic synthesis under hydrothermal conditions: an overview. Adv. Space Res. 33, 88–94 (2004). https://doi.org/10.1016/j.asr.2003.05.006
Simoneit, B.R.T., Rushdi, A.I., Deamer, D.W.: Abiotic formation of acylglycerols under simulated hydrothermal conditions and self-assembly properties of such lipid products. Adv. Space Res. 40, 1649–1656 (2007). https://doi.org/10.1016/j.asr.2007.07.034
Szostak, J.W.: Systems chemistry on early Earth. Nature. 459, 171–172 (2009). https://doi.org/10.1038/459171a
Szostak, J.W., Bartel, D.P., Luisi, P.L.: Synthesizing life. Nature. 409, 387–390 (2001). https://doi.org/10.1038/35053176
Toparlak, D., Karki, M., Egas Ortuno, V., et al.: Cyclophospholipids increase protocellular stability to metal ions. Small. 1903381, 1–8 (2019). https://doi.org/10.1002/smll.201903381
Vitas, M., Dobovišek, A.: Towards a general definition of life. Origin. Life Evol. Biosph. 49, 77–88 (2019). https://doi.org/10.1007/s11084-019-09578-5
Vlassov, A., Khvorova, A., Yarus, M.: Binding and disruption of phospholipid bilayers by supramolecular RNA complexes. Proc. Natl. Acad. Sci. USA. 98, 7706–7711 (2001). https://doi.org/10.1073/pnas.141041098
Walde, P.: Surfactant assemblies and their various possible roles for the origin(s) of life. Origin Life Evol. Biosph. 36(2), 109–150 (2006)
Walde, P., Wick, R., Fresta, M., et al.: Autopoietic self-reproduction of fatty acid vesicles. J. Am. Chem. Soc. 116, 11649–11654 (1994). https://doi.org/10.1021/ja00105a004
Walde, P., Cosentino, K., Engel, H., Stano, P.: Giant vesicles: preparations and applications. ChemBioChem. 11, 848–865 (2010). https://doi.org/10.1002/cbic.201000010
Zhu, T.F., Szostak, J.W.: Coupled growth and division of model protocell membranes. J. Am. Chem. Soc. 131, 5705–5713 (2009). https://doi.org/10.1021/ja900919c
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Lopez, A., Chieffo, C., Fiore, M. (2021). Abiotic Synthesis and Role of Amphiphiles in the Encapsulation Process in Life’s Origin. In: Neubeck, A., McMahon, S. (eds) Prebiotic Chemistry and the Origin of Life. Advances in Astrobiology and Biogeophysics. Springer, Cham. https://doi.org/10.1007/978-3-030-81039-9_6
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