The Role of Inflammasome in Cancers and Potential Therapeutic Targets

Farhangnia, Pooya; Safdarian, Amir Reza; Akbarpour, Mahzad

doi:10.1007/978-3-030-80962-1_70-1

44 Accesses

Abstract

Inflammasome is a multi-protein complex that govern the maturation of the pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 in response to a variety of intracellular stimuli. Recent discoveries have demonstrated that inflammasomes are involved in carcinogenesis and tumor progression. As a result, inflammasome has become an attractive target in the treatment of cancer. This chapter elaborates an overview of the biological roles of inflammasomes. Subsequently, we delineate the pivotal roles of the inflammasomes in carcinogenesis and tumor progression, especially in the context of solid tumors. After that, we discuss the approaches and pharmacological agents based on the inhibition of inflammasomes in the context of clinical immuno-oncology.

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Abbreviations

5-FU:: 5-fluorouracil
AIM2:: Absent in melanoma 2
AML:: Acute myeloid leukemia
ANI:: Anisodamine
ASC:: Apoptosis-associated speck-like protein containing a caspase activation and recruitment domain
AT-I:: Atractylenolide-I
ATP:: Adenosine triphosphate
Aβ:: Amyloid-β
BC:: Breast cancer
BM:: Bone marrow
caCRC:: Colitis-associated CRC
CAF:: Cancer associated fibroblast
CAPS:: Cryopyrin-associated periodic syndrome
CC:: Cervical cancer
CLL:: Chronic lymphocytic leukemia
CNS:: Central nervous system
COX-2:: Cyclooxygenase-2
CRC:: Colorectal cancer
CTSB:: Cathepsin-B
DC:: Dendritic cell
DMAPT:: Dimethylaminoparthenolide
EMT:: Epithelial-mesenchymal transition
ER:: Estrogen receptor
GBM:: Glioblastoma
GC:: Gastric cancer
GSDMD:: Gasdermin D
H. pylori :: Helicobacter pylori
HCC:: Hepatocellular carcinoma
HNSCC:: Head and neck squamous cell carcinoma
HPV:: Human papillomavirus
ICE:: IL-1 converting enzyme
IL-1Ra:: IL-1 receptor antagonist
IL1RN:: Interleukin 1 receptor antagonist
IL-1β:: Interleukin-1β
LC:: Lung cancer
LCMV:: Lymphocytic choriomeningitis virus
LPS:: Lipopolysaccharide
MAPK:: Mitogen-activated protein kinase
MDSC:: Myeloid-derived suppressor cell
miR:: Micro RNA
MM:: Multiple myeloma
MMP:: Matrix metalloproteinase
NF-κB:: Nuclear factor-κB
NK:: Natural killer cell
NLR:: Nucleotide-binding domain-like receptor
NLRC4:: NLR family CARD domain containing 4
NLRP1:: NLR family pyrin domain containing 1
NLRP3:: NLR family pyrin domain containing 3
NLRP6:: NLR family pyrin domain containing 6
OCSCC:: Oral cavity squamous cell carcinoma
Ori:: Oridonin
OSCC:: Oral squamous cell carcinoma
PC:: Prostate cancer
PD-L1:: rogrammed cell death ligand 1
PRR:: Pattern recognition receptor
PTL:: Parthenolide
RLR:: RIG-1-like receptor
ROS:: Reactive oxygen species
SNP:: Single-nucleotide polymorphism
TAM:: Tumor-associated macrophage
TGF-β:: Transforming growth factor-beta
TLR:: Toll-like receptor
TME:: Tumor microenvironment
TNBC:: Triple-negative breast cancer
TNF-α:: Tumor necrosis factor-alpha
TQ:: Thymoquinone
TRN:: Tranilast
VEGF:: Vascular endothelial growth factor

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Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Pooya Farhangnia
Immunology Board for Transplantation and Cell-Based Therapeutics (ImmunoTACT), Universal Scientific Education and Research Network (USERN), Chicago, IL, USA
Pooya Farhangnia, Amir Reza Safdarian & Mahzad Akbarpour
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Pooya Farhangnia
Immunology Research Center, Institute of Immunology and Infectious Disease, Iran University of Medical Sciences, Tehran, Iran
Pooya Farhangnia
Advanced Cellular Therapeutics Facility, David and Etta Jonas Center for Cellular Therapy, Hematopoietic Cellular Therapy Program, The University of Chicago Medical Center, Chicago, IL, USA
Mahzad Akbarpour

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Nima Rezaei

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Farhangnia, P., Safdarian, A.R., Akbarpour, M. (2023). The Role of Inflammasome in Cancers and Potential Therapeutic Targets. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_70-1

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Received: 17 July 2022
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Published: 22 March 2023
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