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Factors Affecting Nanoparticle Dose–Exposure and Cell Response

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Nanotoxicology in Humans and the Environment

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

To understand cell response and the dose-dependent interaction between particles and cells, in vitro dosimetry of nanoparticles has become an important concept in predicting the dose delivered to cells that are cultured in plastic wells. The usefulness of any dosimetry method, however, requires a throughout experimental characterization of the physicochemical properties of the particles in the dispersion under study. Here we present the major aspects one must carefully consider and adapt in order to obtain reliable and reproducible results.

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Acknowledgement

The authors are grateful for the financial support of the Adolphe Merkle Foundation, the University of Fribourg, and the Swiss National Science Foundation through the National Centre of Competence in Research Bio-Inspired Materials. The authors are also grateful to Dr. Barbara Drasler for carefully reading the chapter.

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Authors and Affiliations

  1. Adolphe Merkle Institute, Fribourg, Switzerland

    Sandor Balog, Barbara Rothen-Rutishauser & Alke Petri-Fink

  2. Department of Chemistry, University of Fribourg, Fribourg, Switzerland

    Alke Petri-Fink

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  1. Sandor Balog
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  2. Barbara Rothen-Rutishauser
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  3. Alke Petri-Fink
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Correspondence to Alke Petri-Fink .

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Editors and Affiliations

  1. Center for Environmental Nanoscience and Risk, Department of ENHS, University of South Carolina, Columbia, SC, USA

    Jamie R. Lead

  2. Institute of Life Science, Ctr. for NanoHealth, Swansea University Medical School, Swansea, Mid Glamorgan, UK

    Shareen H. Doak

  3. Institute of Life Science, Ctr. for NanoHealth, Swansea University Medical School, Swansea, UK

    Martin J.D. Clift

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Balog, S., Rothen-Rutishauser, B., Petri-Fink, A. (2021). Factors Affecting Nanoparticle Dose–Exposure and Cell Response. In: Lead, J.R., Doak, S.H., Clift, M.J. (eds) Nanotoxicology in Humans and the Environment. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-79808-6_5

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