Abstract
Stem cells have been extensively used in tissue repair and cell tissue engineering in preclinical and clinical conditions. One of the stem cells’ characteristics is to provide an ample number of cells for transplantation purposes. Although embryonic stem cells (ESCs) are considered a potential source of stem cells, due to ethical concerns, there is not much progress in using ESCs in clinical conditions. The application of adult mesenchymal stem cells (MSCs) derived from bone marrow, and the umbilical cord is extensively used to treat many degenerative diseases. Many clinical trials have been successfully done in the last few years. Moreover, many clinical trials with different phases are under progress where adult MSCs are transplanted in patients with different degenerative diseases. More than 5000 registered clinical trials are in progress as per the ClinicalTrials.gov where stem cells have been applied in disease conditions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bersenev, A. (2015). Cell therapy clinical trials—2014 report. CellTrials blog, January 22, 2015. http://celltrials.info/2015/01/22/2014-report/
Clinical trials of government of USA. https://www.clinicaltrials.gov/
Cyranoski, D. (2014). Japanese woman is first recipient of next-generation stem cells. Nature News (Nature Publishing Group), September 12, 2014. http://www.nature.com/news/japanese-woman-is-first-recipient-of-next-generation-stem-cells-1.15915
Kushner, J. A., MacDonald, P. E., & Atkinson, M. A. (2014). Stem cells to insulin secreting cells: Two steps forward and now a time to pause? Cell Stem Cell, 15, 535–536.
List of stem cell clinical trials. https://stemcellsportal.com/stem-cells-translational-medicine-clinical-trials-portal
Ratcliffe, E., Glen, K. E., Naing, M. W., & Williams, D. J. (2013). Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: Case studies. British Medical Bulletin, 108, 73–94.
Schwartz, S. D., Hubschman, J. P., Heilwell, G., Franco-Cardenas, V., Pan, C. K., Ostrick, R. M., Mickunas, E., Gay, R., Klimanskaya, I., & Lanza, R. (2012). Embryonic stem cell trials for macular degeneration: A preliminary report. Lancet, 379, 713–720.
Schwartz, S. D., Regillo, C. D., Lam, B. L., Eliott, D., Rosenfeld, P. J., Gregori, N. Z., Hubschman, J. P., Davis, J. L., Heilwell, G., Spirn, M., et al. (2015). Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: Follow-up of two open-label phase 1/2 studies. Lancet, 385, 509.
Trounson, A., Baum, E., Gibbons, D., & Tekamp-Olson, P. (2010). Developing a case study model for successful translation of stem cell therapies. Cell Stem Cell, 6, 513–516.
Trounson, A., & McDonald, C. (2015). Stem Cell Therapies in Clinical Trials: Progress and Challenges. Cell Stem Cell, 17(1), 11–22. https://doi.org/10.1016/j.stem.2015.06.007 PMID: 26140604.
Trounson, A., Thakar, R. G., Lomax, G., & Gibbons, D. (2011). Clinical trials for stem cell therapies. BMC Medicine, 9, 52.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Khan, F.A., Aldahhan, R., Alrushaid, N. (2021). Stem Cells in Regenerative Medicine: Clinical Trials. In: Khan, F.A. (eds) Advances in Application of Stem Cells: From Bench to Clinics. Stem Cell Biology and Regenerative Medicine, vol 69. Humana, Cham. https://doi.org/10.1007/978-3-030-78101-9_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-78101-9_9
Published:
Publisher Name: Humana, Cham
Print ISBN: 978-3-030-78100-2
Online ISBN: 978-3-030-78101-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)