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Application of Stem Cells in Treatment of Bone Diseases: Pre-clinical and Clinical Perspectives

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Advances in Application of Stem Cells: From Bench to Clinics

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL,volume 69))

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Abstract

The word “Stem Cell” first appeared in the scientific literature in 1868. Stem cells are cells which have the ability to self-renew and give rise to differentiated cells. In 1960, McCullough and till reported that the living tissues came from stem cells and with the concept of self-renewal. In the twentieth century with the discovery of hESC, it was believed that stem cells will give potential therapies for the chronic human diseases. There was a flood of research in every field including orthopaedic surgery. As the Mesenchymal stem cells are able to develop into tissues including bone, cartilage, muscle, tendon, and ligament. Trials were instituted to treat non-unions, long-bone defects, spinal cord Injury, osteonecrosis of head of femur, spinal cord injury, osteochondral defects, osteoarthritis, rotator cuff injuries, and tendon and ligament ruptures. Stem cell therapy requires a clear comprehension of the orthopaedic disease process before clinicians embark on the new strategies to treat old diseases. It is also imperative that practicing clinicians to have a knowledge of different cell sources like autologous, allogeneic and iPSC, and the culture methods and their limitations.

It is also strongly recommended that orthopaedic surgeons should not give up the well-known recommended treatment modalities of treatment until stem cell therapy is proved safe, efficacious, and cost effective.

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  1. Department of Orthopaedic Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Mir Sadat-Ali

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  1. Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Firdos Alam Khan

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Sadat-Ali, M. (2021). Application of Stem Cells in Treatment of Bone Diseases: Pre-clinical and Clinical Perspectives. In: Khan, F.A. (eds) Advances in Application of Stem Cells: From Bench to Clinics. Stem Cell Biology and Regenerative Medicine, vol 69. Humana, Cham. https://doi.org/10.1007/978-3-030-78101-9_8

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