Abstract
Regenerative medicine research provides a new hope in treatment of patients suffering from severe injuries or chronic diseases. The increased interest in stem/progenitor cells is encouraged by their biological nature for self-renewal and multilineage differentiation potential. Cornerstones for tissue engineering are stem/progenitor cells, scaffolds, and morphogenic signals, the dynamic actors that induce cells for tissue or organ regeneration. The dental medicine field was recently tempted to test the possible applications of tissue engineering in regenerating dental structures. Dental caries which is a common worldwide health problem, causing enamel and dentin destruction, besides if not treated progresses to the dental pulp with loss of its vitality. As the available artificial filling materials used to restore the affected dental tissues have many inherent deficiencies, many recent approaches have been proposed to regenerate the hard dental tissues. There has been an increasing demand to regenerate enamel, dentin, and maintain pulp vitality. Stem/Progenitor cell therapy could aid in the regeneration of enamel and dentin/pulp complex as a more conservative replacement to conventional restorative therapies. In view of these facts, this chapter will discuss the recent approaches in tissue engineering for enamel, dentin, and pulp regeneration.
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Ahmed, G.M., Abouauf, E.A., AbuBakr, N., Elarab, A.E., Fawzy El-Sayed, K. (2021). Stem Cell-Based Tissue Engineering for Functional Enamel and Dentin/Pulp Complex: A Potential Alternative to the Restorative Therapies. In: Haider, K.H. (eds) Stem Cells. Springer, Cham. https://doi.org/10.1007/978-3-030-77052-5_10
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