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Chordoma of the Spine

A Comprehensive Review

  • Book
  • © 2021

Overview

Editors:
  1. Daniel M. Sciubba

    1. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Joseph H. Schwab

    1. Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Presents a comprehensive review of modern treatment

  • Includes extensive illustrations and photographs

  • Written by experts in the field

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Pathophysiology and Molecular Mechanisms of Chordoma

    1. Front Matter

      Pages 1-1
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    2. Notochordal Morphogenesis and the Origin of Chordoma

      • Matthew L. Goodwin, David C. Clever
      Pages 3-12

    3. Molecular Morphogenesis and Genetic Mechanisms of Spinal Chordoma

      • Connor Liu, Ann Liu, Chetan Bettegowda
      Pages 13-29

  3. Epidemiology, Clinical History, and Work-Up for Chordoma

    1. Front Matter

      Pages 31-31
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    2. Historical Overview, Demographics, and Clinical Presentation of Spinal Chordoma

      • Zach Pennington, Andrew Schilling, Joseph H. Schwab, Daniel M. Sciubba
      Pages 33-54

    3. Clinical Work-Up, Diagnostic Imaging, and Biopsy

      • Daniel Ryan, John M. Gross, Zach Pennington, Majid Khan
      Pages 55-76

    4. Histopathologic Classification of Spinal Chordoma

      • John M. Gross, Edward F. McCarthy
      Pages 77-89

    5. Multidisciplinary Planning for Treatment of Chordoma

      • Nicholas A. Shepard, Matthew W. Colman
      Pages 91-108

  4. Surgical Management of Chordoma

    1. Front Matter

      Pages 109-109
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    2. Surgical Management of Chordoma of the Occipitocervical Junction

      • Zach Pennington, Jeff Ehresman, Andrew Schilling, Daniel M. Sciubba
      Pages 111-145

    3. Surgical Management of Chordoma of the Cervical Spine

      • Oliver G. S. Ayling, Nicolas Dea
      Pages 147-157

    4. Surgical Management of Chordoma in the Thoracic Spine

      • Daniel G. Tobert, John H. Shin, Joseph H. Schwab
      Pages 159-177

    5. Surgical Management of Chordoma of the Lumbar Spine

      • Sutipat Pairojboriboon, Amanda Sacino, Sheng-Fu Larry Lo
      Pages 179-191

    6. Surgical Management of Chordoma of the Sacrum

      • Peter S. Rose, Matthew T. Houdek, Cory G. Couch
      Pages 193-213

    7. Soft Tissue Reconstruction Following Surgery for Sacral Chordoma

      • Rachel Skladman, Zach Pennington, Justin M. Sacks
      Pages 215-231

    8. Vascular Reconstruction After En Bloc Resection

      • Daniel G. Tobert, Joseph H. Schwab
      Pages 233-246

  5. Radiation and Chemotherapeutic Adjuvants for Chordoma

    1. Front Matter

      Pages 247-247
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    2. Conventionally Fractionated and Hypofractionated Photon Radiation Therapy in the Management of Chordoma

      • Chunzi Jenny Jin, Yoshiya Josh Yamada
      Pages 249-263

    3. Heavy Particle Therapy for Chordoma

      • David J. Konieczkowski, Reiko Imai, Thomas F. DeLaney
      Pages 265-287
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Keywords

About this book

This book provides a comprehensive review of the epidemiology, pathogenesis, diagnosis, and management of chordomas of the mobile spine and sacrum. Historically, knowledge about how to deliver such state-of-the-art care has not been widespread, resulting in inconsistent treatment, and, all too often, suboptimal outcomes for chordoma patients. This text is an important step towards broadening that knowledge, and, in turn, improving the care provided to chordoma patients. The book is divided into 4 parts comprising 16 chapters. The first part focuses on the pathophysiology and molecular drivers of chordoma. The second focuses on the epidemiology and clinical history, as well as the histological, oncologic, and radiographic work-up of chordoma. The third part focuses primarily on the technical aspects of surgery for chordoma. It is broken down by anatomic region, with the final two chapters focusing on the soft tissue and bony reconstruction following chordoma resection. The last part focuses on the exciting field of adjuvant therapies for chordoma. This includes both radiation therapies and novel chemotherapeutic options for recurrent, metastatic, and dedifferentiated chordoma.


 
Written by world experts from leading chordoma centers, Chordoma of the Spine serves as a valuable reference for spinal oncologists and general spine surgeons who may encounter chordoma patients in their practice. It provides the most up-to-date evidence regarding all aspects of treating patients with this disease. By focusing on this specific pathology of the spine, this resource condenses expert-level research into understandable treatment algorithms.

Editors and Affiliations

  • Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA

    Daniel M. Sciubba

  • Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA

    Joseph H. Schwab

About the editors

Daniel M. Sciubba
Department of Neurosurgery
Zucker School of Medicine at Hofstra University/Northwell Health
Manhasset, NY
USA



Joseph H. Schwab
Department of Orthopaedic Surgery
Massachusetts General Hospital
Harvard Medical School
Boston, MA
USA



Bibliographic Information

  • Book Title: Chordoma of the Spine

  • Book Subtitle: A Comprehensive Review

  • Editors: Daniel M. Sciubba, Joseph H. Schwab

  • DOI: https://doi.org/10.1007/978-3-030-76201-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-76200-1Published: 23 July 2021

  • Softcover ISBN: 978-3-030-76203-2Published: 24 July 2022

  • eBook ISBN: 978-3-030-76201-8Published: 22 July 2021

  • Edition Number: 1

  • Number of Pages: XX, 307

  • Number of Illustrations: 34 b/w illustrations, 62 illustrations in colour

  • Topics: Surgery, Neurosurgery

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