Abstract
Disorders of hypopigmentation (DOH) are a group of cutaneous conditions that cause loss of skin pigment. DOH can occur in any skin type but are more apparent in skin of color (SOC) because of the stark contrast between normal skin and depigmented or hypopigmented skin. Although not life threatening, DOH can be psychologically devastating in afflicted individuals.
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Saleem MD, Oussedik E, Picardo M, Schoch JJ. Acquired disorders with hypopigmentation: a clinical approach to diagnosis and treatment. J Am Acad Dermatol. 2018;80(5):1233–1250.e10.
Adams DR, Menezes S, Jauregui R, Valivullah ZM, Power B, Abraham M, Jeffrey BG, Garced A, Alur RP, Cunningham D, Wiggs E, Merideth MA, Chiang PW, Bernstein S, Ito S, Wakamatsu K, Jack RM, Introne WJ, Gahl WA, Brooks BP. One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B. JCI Insight. 2019;4(2):e124387. https://doi.org/10.1172/jci.insight.124387.
Adebajo SB. An epidemiological survey of the use of cosmetic skin lightening cosmetics among traders in Lagos, Nigeria. West Afr J Med. 2002;21:51–5.
Agarwal S, Ojha A. Piebaldism: a brief report and review of the literature. Indian Dermatol Online J. 2012;3(2):144–7. https://doi.org/10.4103/2229-5178.96722.
Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65(3):473–91. https://doi.org/10.1016/j.jaad.2010.11.061.
Al-Mutairi N, Hadad AA. Efficacy of 308-nm xenon chloride excimer laser in pityriasis alba. Dermatol Surg. 2012;38(4):604–9. https://doi.org/10.1111/j.1524-4725.2011.02223.x.
Bellew SG, Alster TS. Treatment of exogenous ochronosis with a Q-switched alexandrite (755 nm) laser. Dermatol Surg. 2004;30:555–8. https://doi.org/10.1111/j.1524-4725.2004.30177.x.
Bhat RM, Prakash C. Leprosy: an overview of pathophysiology. Interdiscip Perspect Infect Dis. 2012;2012, Article ID 181089, 6 pages https://doi.org/10.1155/2012/181089.
Briganti S, Camera E, Picardo M. Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Res. 2003;16(2):101–10. https://doi.org/10.1034/j.1600-0749.2003.00029.x.
Bulengo-Ransby SM, Griffiths CE, Kimbrough-Green CK, Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. N Engl J Med. 1993;328(20):1438–43. https://doi.org/10.1056/NEJM199305203282002.
Burns RL, Prevost-Blank PL, Lawry MA, Lawry TB, Faria DT, Fivenson DP. Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. Dermatol Surg. 1997;23(3):171–4; discussion 175. https://doi.org/10.1111/j.1524-4725.1997.tb00014.x.
Casacci M, Thomas P, Pacifico A, Bonnevalle A, Paro Vidolin A, Leone G. Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo--a multicentre controlled study. J Eur Acad Dermatol Venereol. 2007;21(7):956–63. https://doi.org/10.1111/j.1468-3083.2007.02151.x.
Charlin R, Barcaui CB, Bernard KK, Brazuna Soares D, Rabello-Fonseca R, Azulay-Abulafia L. Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. Int J Dermatol 2008; 47:19–23. doi: https://doi.org/10.1111/j.1365-4632.2007.03351.x.
Dogliotti M, Leibowitz M. Granulomatous ochronosis – a cosmetic-induced skin disorder in Blacks. S Afr Med J. 1979;56(19):757–60.
Ezzedine K, Eleftheriadou V, Whitton M, van Geel N. Vitiligo. Lancet. 2015;386(9988):74–84. https://doi.org/10.1016/S0140-6736(14)60763-7.
Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, Parsad D, van Geel N, Le Poole IC, Oiso N, Benzekri L, Spritz R, Gauthier Y, Hann SK, Picardo M, Taieb A, et al. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012;25(3):E1–E13. https://doi.org/10.1111/j.1755-148X.2012.00997.x.
Felsten LM, Alikhan A, Petronic-Rosic V. Vitiligo: a comprehensive overview Part II: treatment options and approach to treatment. J Am Acad Dermatol. 2011;65(3):493–514. https://doi.org/10.1016/j.jaad.2010.10.043.
Fistarol SK, Itin PH. Disorders of pigmentation. J Dtsch Dermatol Ges. 2010;8(3):187–201. https://doi.org/10.1111/j.1610-0387.2009.07137.x.
Fujita WH, McCormick CL, Parneix-Spake A. An exploratory study to evaluate the efficacy of pimecrolimus cream 1% for the treatment of pityriasis alba. Int J Dermatol. 2007;46(7):700–5. https://doi.org/10.1111/j.1365-4632.2007.03145.x.
Gawkrodger DJ, Ormerod AD, Shaw L, Mauri-Sole I, Whitton ME, Watts MJ, Anstey AV, Ingham J, Young K, Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists; Clinical Standards Department, Royal College of Physicians of London; Cochrane Skin Group; Vitiligo Society. Guideline for the diagnosis and management of vitiligo. Br J Dermatol. 2008;159(5):1051–76. https://doi.org/10.1111/j.1365-2133.2008.08881.x.
Grimes P, Callender V. Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study. Cutis. 2006;77(1):45–50.
Grimes PE, Stockton T. Pigmentary disorders in blacks. Dermatol Clin. 1988;6:271–81.
Grimes PE. Management of hyperpigmentation in darker racial ethnic groups. Semin Cutan Med Surg. 2009;28(2):77–85. https://doi.org/10.1016/j.sder.2009.04.001.
Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol. 1995;131(12):1453–7. https://doi.org/10.1001/archderm.131.12.1453.
Grimes PE. The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatol Surg. 1999;25(1):18–22. https://doi.org/10.1046/j.1524-4725.1999.08145.x.
Halder R, editor. Dermatology and dermatological therapy of pigmented skins. Boca Raton: CRC Press; 2006. p. 91, 93–95. https://doi.org/10.3109/9780203485699.
Hardwick N, Van Gelder LW, Van der Merwe CA, Van der Merwe MP. Exogenous ochronosis: an epidemiological study. Br J Dermatol. 1989;120(2):229–38. https://doi.org/10.1111/j.1365-2133.1989.tb07787.x.
Hong ES, Zeeb H, Repacholi MH. Albinism in Africa as a public health issue. BMC Public Health. 2006;6:212. https://doi.org/10.1186/1471-2458-6-212.
Iozumi K, Hoganson GE, Pennella R, Everett MA, Fuller BB. Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes. J Invest Dermatol. 1993;100(6):806–11. https://doi.org/10.1111/1523-1747.ep12476630.
Janjua SA, Khachemoune A, Guldbakke KK. Piebaldism: a case report and a concise review of the literature. Cutis. 2007;80(5):411–4.
Javaheri SM, Handa S, Kaur I, Kumar B. Safety and efficacy of glycolic acid facial peel in Indian women with melasma. Int J Dermatol. 2001;40(5):354–7. https://doi.org/10.1046/j.1365-4362.2001.01149.x.
Juntongjin P, Laosakul K. Idiopathic Guttate Hypomelanosis: a review of its etiology, pathogenesis, findings, and treatments. Am J Clin Dermatol. 2016;17(4):403–11. https://doi.org/10.1007/s40257-016-0195-3.
Kimbrough-Green CK, Griffiths CE, Finkel LJ, Hamilton TA, Bulengo-Ransby SM, Ellis CN, Voorhees JJ. Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial. Arch Dermatol. 1994;130(6):727–33.
Kumarasinghe P, Uprety S, Sarkar R. Hypopigmentary disorders in Asian patients. Pigment Int. 2017;4(10):13–20. https://doi.org/10.4103/2349-5847.208351.
Levitt J. The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register. J Am Acad Dermatol. 2007;57(5):854–72. https://doi.org/10.1016/j.jaad.2007.02.020.
Majid I. Vitiligo management: an update. BJMP. 2010;3(3):a332.
Martin RF, Lugo-Somolinos A, Sanchez JL. Clinicopathologic study on pityriasis alba. Bol Asoc Med P R. 1990;82(10):463–5.
Martins VMR, et al. Exogenous ochronosis: case report and literature review. An Bras Dermatol. 2012;87(4):633–6.
Massone C, Cavalchini A, Clapasson A, Nunzi E. Hypopigmented macules: leprosy, atopy or pityriasis versicolor? G Ital Dermatol Venereol. 2010;145(6):779–82.
Miazek N, Michalek I, Pawlowska-Kisiel M, Olszewska M, Rudnicka L. Pityriasis Alba–common disease, enigmatic entity: up-to-date review of the literature. Pediatr Dermatol. 2015;32(6):786–91. https://doi.org/10.1111/pde.12683.
Moreno-Cruz B, Torres-Alvarez B, Hernandez-Blanco D, Castanedo-Cazares JP. Double-blind, placebo-controlled, randomized study comparing 0.0003% calcitriol with 0.1% tacrolimus ointments for the treatment of endemic pityriasis alba. Dermatol Res Pract. 2012;2012:303275. https://doi.org/10.1155/2012/303275.
Orfanos CE. Oculocutaneous albinism. In: Orfanos CE, Zouboulis CC, Assaf C, editors. Pigmented ethnic skin and imported dermatoses. 1st ed. Switzerland: Springer; 2018. Chapter 41: p. 463–469.
Ortonne JP, Arellano I, Berneburg M, Cestari T, Chan H, Grimes P, Hexsel D, Im S, Lim J, Lui H, Pandya A, Picardo M, Rendon M, Taylor S, Van Der Veen JP, Westerhof W. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma. J Eur Acad Dermatol Venereol. 2009;23(11):1254–62. https://doi.org/10.1111/j.1468-3083.2009.03295.x.
Pereira D, Araujo E, Patuzzo F. Profile of albinism with low vision and improvement of visual acuity with the adaptation of optical and / or electronic resources. Rev Bras Oftalmol. 2016;75 https://doi.org/10.5935/0034-7280.20160092.
Ploysangam T, Dee-Ananlap S, Suvanprakorn P. Treatment of idiopathic guttate hypomelanosis with liquid nitrogen: light and electron microscopic studies. J Am Acad Dermatol. 1990;23(4 Pt 1):681–4. https://doi.org/10.1016/0190-9622(90)70273-K.
Rerknimitr P, Disphanurat W, Achariyakul M. Topical tacrolimus significantly promotes repigmentation in idiopathic guttate hypomelanosis: a double-blind, randomized, placebo-controlled study. J Eur Acad Dermatol Venereol. 2013;27(4):460–4. https://doi.org/10.1111/j.1468-3083.2012.04462.x.
Rocha MVM, Renê Diógenes de SA, Carvalho de PN, Frota TCA, Saraiva GLM, Lucena de CFR. Exogenous ochronosis: case report and literature review. An Bras Dermatol. [Internet]. 2012 Aug [cited 2020 Nov 19]; 87(4):633–36. https://doi.org/10.1590/S0365-05962012000400021.
Shin MK, Jeong KH, Oh IH, Choe BK, Lee MH. Clinical features of idiopathic guttate hypomelanosis in 646 subjects and association with other aspects of photoaging. Int J Dermatol. 2011;50(7):798–805. https://doi.org/10.1111/j.1365-4632.2010.04743.x.
Spencer JM, Nossa R, Ajmeri J. Treatment of vitiligo with the 308-nm excimer laser: a pilot study. J Am Acad Dermatol. 2002;46(5):727–31. https://doi.org/10.1067/mjd.2002.121357.
Taieb A, Picardo M. Clinical practice. Vitiligo N Engl J Med. 2009;360(2):160–9. https://doi.org/10.1056/NEJMcp0804388.
Taylor A, Pawaskar M, Taylor SL, Balkrishnan R, Feldman SR. Prevalence of pigmentary disorders and their impact on quality of life: a prospective cohort study. J Cosmet Dermatol. 2008;7(3):164–8. https://doi.org/10.1111/j.1473-2165.2008.00384.x.
The Lancet Child Adolescent Health. Albinism: myths and reality. Lancet Child Adolesc Health. 2019;3(8):511. https://doi.org/10.1016/S2352-4642(19)30206-8. Epub 2019 Jun 27
The moon children of Kuna Yala: Albinism in San Blas islands of Panama: review, directions in research and aid. Arts, History and Humanities of Dermatology. JAAD. 2011; 64(2 supp; 1):AB26. https://doi.org/10.1016/j.jaad.2010.09.128.
Vachiramon V, Thadanipon K. Postinflammatory hypopigmentation. Clin Exp Dermatol. 2011;36(7):708–14. https://doi.org/10.1111/j.1365-2230.2011.04088.x.
Valente Duarte de Sousa IC. Fixed drug eruption. N Engl J Med. 2011;365:e12. https://doi.org/10.1056/NEJMicm1013871.
van den Boorn JG, Konijnenberg D, Dellemijn TA, van der Veen JP, Bos JD, Melief CJ, Vyth-Dreese FA, Luiten RM. Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients. J Invest Dermatol. 2009;129(9):2220–32. https://doi.org/10.1038/jid.2009.32. Epub 2009 Feb 26
WHO. Leprosy elimination. WHO regional office for Africa. 2015; www.afro.who.int.
WHO. Leprosy. Key facts. 2019. https://www.who.int/news-room/fact-sheets/detail/leprosy#
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Donkor, C.M.Y.A., Aryee-Boi, J., Osazuwa, I.R., Afflu, F.K., Alexis, A.F., Ansah-Addo, S. (2021). Disorders of Pigmentation: Hypopigmentation. In: Atlas of Dermatological Conditions in Populations of African Ancestry. Springer, Cham. https://doi.org/10.1007/978-3-030-72617-1_7
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