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Role of Endoscopic Ultrasound in Pancreatic Cancer Screening

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Endoscopic Ultrasound Management of Pancreatic Lesions

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Abstract

Pancreatic neoplasia if early detected is potentially curable. This increases the importance of screening in patients at risk. Despite having an incomplete understanding of risk factors for pancreatic cancer, some guidelines are now available helping to select and to screen high-risk individuals. Five groups of high-risk individuals have been detected: patients with a family history of pancreatic cancer, pancreatic cancer associated with inherited cancer syndrome (mutation carriers), history of pancreatitis, elderly patients with new-onset of type 2 diabetes, and patients with precancerous lesions of the pancreas. Principal modalities of imaging to detect pancreatic tumor are endoscopic ultrasound (EUS), magnetic resonance imaging (MRI), magnetic resonance cholangiopancreatography, multidetector computed tomography, positron emission tomography, probe-based confocal laser endomicroscopy, and endoscopic cholangiopancreatography but EUS and MRI are considered the most accurate choice for pancreatic imaging screening. In particular, evidence suggests that EUS may have distinct advantages in pancreatic cancer diagnosis when compared to other modalities. EUS can provide high-resolution images of the pancreas, can accurately detect IPMNs, and can visualize characteristics that are signal of increased risk of malignancy.

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Acknowledgments

This work was supported by the Italian Ministry of Health (RF-2016-02361525) to Renato Cannizzaro and Paola Spessotto and the Ministero della Salute Ricerca Corrente.

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Authors and Affiliations

  1. Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

    Renato Cannizzaro, Raffaella Magris, Stefania Maiero, Giovanni Guarnieri & Mara Fornasarig

  2. S.O.C. Gastroenterologia Oncologica Sperimentale, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy

    Renato Cannizzaro

  3. Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

    Vincenzo Canzonieri

  4. Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy

    Vincenzo Canzonieri

Authors
  1. Renato Cannizzaro
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  2. Raffaella Magris
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  3. Stefania Maiero
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  4. Giovanni Guarnieri
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  5. Mara Fornasarig
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  6. Vincenzo Canzonieri
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Corresponding author

Correspondence to Renato Cannizzaro .

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Editors and Affiliations

  1. Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

    Antonio Facciorusso

  2. Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

    Nicola Muscatiello

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Cannizzaro, R., Magris, R., Maiero, S., Guarnieri, G., Fornasarig, M., Canzonieri, V. (2021). Role of Endoscopic Ultrasound in Pancreatic Cancer Screening. In: Facciorusso, A., Muscatiello, N. (eds) Endoscopic Ultrasound Management of Pancreatic Lesions. Springer, Cham. https://doi.org/10.1007/978-3-030-71937-1_11

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  • DOI: https://doi.org/10.1007/978-3-030-71937-1_11

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