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HIV-HBV Co-infection, Clinical Concerns

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Human Viruses: Diseases, Treatments and Vaccines

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Abstract

Both Human Immunodeficiency Virus and Hepatitis B virus result in chronic disease states resulting in clinical concerns both acute and chronic. There is no cure for either virus and both require chronic medication which can present challenges in terms of disease surveillance and management of decompensation. Even in the presence of appropriate antiviral therapy, mortality remains high in the HIV-HBV co-infected population with accelerated hepatic fibrosis and significantly increased incidence of hepatocellular cancer. While multiple risk factors and possible etiologies have been uncovered, the relative contribution of each has yet to be adequately determined, though further elucidation of these risks may present novel approaches for therapy. That stated, as discussed, antiviral therapy comes with its inherent risks in terms of both side effects of medication as well as its interactions. This review focuses to review the prevalence of co-infection with these viruses and the resultant special clinical concerns in this population.

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Authors and Affiliations

  1. Fellow, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, Columbia, MO, USA

    Ryan D. Heath

  2. Department of Internal Medicine, University of Missouri-Columbia, Columbia, MO, USA

    Ali Syed & Suha Abu Khalaf

  3. Associate Professor of Clinical Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, Columbia, MO, USA

    Veysel Tahan

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  1. Ryan D. Heath
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  4. Veysel Tahan
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All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.

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Correspondence to Veysel Tahan .

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  1. Wollaton, Nottingham, UK

    Shamim I. Ahmad

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Heath, R.D., Syed, A., Khalaf, S.A., Tahan, V. (2021). HIV-HBV Co-infection, Clinical Concerns. In: Ahmad, S.I. (eds) Human Viruses: Diseases, Treatments and Vaccines . Springer, Cham. https://doi.org/10.1007/978-3-030-71165-8_20

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