Abstract
The purpose of this chapter is to discuss the production of biocompatible green nanomaterials for biomedical applications using green nanotechnology. To enhance drug loading and delivery, these nanomaterials are engineered with immunomodulatory ligands such as phytochemicals (Epigallocatechin gallate, Mangiferin, Resveratrol), proteins (albumin and papain), crosslinked hydrogels, and nanogels. The nanomaterials described herein are synthesized via redox potential of electron-dense phytochemicals that reduce metallic precursors to their stable corresponding nanoparticles and via water radiolysis with ionizing radiation as a green approach (due to the absence of any reducing agent) for use as radiosensitizers (albumin and papain nanoparticles) in nuclear medicine – theranostics applications. The phytochemicals facilitate the delivery of nanoparticles through receptor mediated endocytosis, while the proteins such as papain, due to their proteolytic action enhances the permeation of nanoparticles into tumor tissue, and albumin increase the pharmacokinetic efficiency of these nanoparticles. The nanoparticles developed have shown effectiveness against a variety of human cancers while posing no toxicity to normal tissue. Additionally, a pilot human clinical combing Ayurvedic medicine with green nanomedicine is given as a novel approach for treating breast cancer and other related illnesses. Finally, the importance of ecotoxicology for nanomaterials is discussed in order to provide safety data in relevant multiple species (fish, daphnia, algae, rodents, etc.) with paratope/epitope distributions for evaluating tissue cross-reactivity profiles in human tissues and to provide critical information on in vivo toxicity in order to predict the possible adverse effects of nanomaterials on human and environmental health as an effort to establish regulatory limits and ISO standards for nanomaterials.
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References
Al-Yasiri AY, White NE, Katti KV, Loyalka SK (2019) Estimation of tumor and local tissue dose in gold nanoparticles radiotherapy for prostate cancer. Rep Pract Oncol Radiother 24(3):288–293. https://doi.org/10.1016/j.rpor.2019.02.006
Amri E, Mamboya F (2012) Papain, a plant enzyme of biological importance: a review. Am J Biochem Biotechnol 8:99–104. https://doi.org/10.3844/ajbbsp.2012.99.104
Aranda-Lara L, Morales-Avila E, Luna-Gutiérrez MA, Olivé-Alvarez E, Isaac-Olivé K (2020) Radiolabeled liposomes and lipoproteins as lipidic nanoparticles for imaging and therapy. Chem Phys Lipids 230:104934. https://doi.org/10.1016/j.chemphyslip.2020.104934
Budama-Kilinc Y, Cakir-Koc R, Kecel-Gunduz S, Zorlu T, Kokcu Y, Bicak B, Karavelioglu Z, Ozel AE (2018) Papain loaded poly(ε-Caprolactone) nanoparticles: in-silico and in-vitro studies. J Fluoresc 28(5):1127–1142. https://doi.org/10.1007/s10895-018-2276-6
Cho MH, Li Y, Lo P-C, Lee H, Choi Y (2020) Fucoidan-based theranostic nanogel for enhancing imaging and photodynamic therapy of cancer. Nano-Micro Lett 12(1):47. https://doi.org/10.1007/s40820-020-0384-8
Chong HC, Tan CK, Huang R-L, Tan NS (2012) Matricellular proteins: a sticky affair with cancers. J Oncol 2012:351089. https://doi.org/10.1155/2012/351089
de Lima CSA, Balogh TS, Varca JPRO, Varca GHC, Lugão AB, Camacho-Cruz LA, Bucio E, Kadlubowski SS (2020) An updated review of macro, micro, and nanostructured hydrogels for biomedical and pharmaceutical applications. Pharmaceutics 12(10):1–28. https://doi.org/10.3390/pharmaceutics12100970
Fazolin GN, Varca GHCC, Kadlubowski S, Sowinski S, Lugão AB (2020) The effects of radiation and experimental conditions over papain nanoparticle formation: towards a new generation synthesis. Radiat Phys Chem 169:107984. https://doi.org/10.1016/j.radphyschem.2018.08.033
Freitas LFd, da Cruz CPC, Cavalcante AK, dos Santos Batista JG, Varca GHC, Mathor MB, Lugão AB (2020) Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction. Radiat Phys Chem 174:108959. https://doi.org/10.1016/j.radphyschem.2020.108959
Gamal-Eldeen AM, Moustafa D, El-Daly SM, Abo-Zeid MAMM, Saleh S, Khoobchandani M, Katti KVKKV, Shukla R, Katti KVKKV (2017) Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice. Biomed Pharmacother 89:1045–1054. https://doi.org/10.1016/j.biopha.2017.03.006
Golombek SK, May JN, Theek B, Appold L, Drude N, Kiessling F, Lammers T (2018) Tumor targeting via EPR: Strategies to enhance patient responses. Adv Drug Deliv Rev 130:17–38. https://doi.org/10.1016/j.addr.2018.07.007. Elsevier B.V
Iqbal H, Yang T, Li T, Zhang M, Ke H, Ding D, Deng Y, Chen H (2020) Serum protein-based nanoparticles for cancer diagnosis and treatment. J Control Release. https://doi.org/10.1016/j.jconrel.2020.10.030
Kadlubowski S (2014) Radiation-induced synthesis of nanogels based on poly(N-vinyl-2-pyrrolidone)-A review. Radiat Phys Chem 102:29–39. https://doi.org/10.1016/j.radphyschem.2014.04.016. Elsevier Ltd
Katti KV, Khoobchandani M, Thipe VC et al (2018) Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles. J Radioanal Nucl Chem 318:1737–1747. https://doi.org/10.1007/s10967-018-6320-4
Kenanova VE, Olafsen T, Salazar FB, Williams LE, Knowles S, Wu AM (2010) Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins. Protein Eng Design Select PEDS 23(10):789–798. https://doi.org/10.1093/protein/gzq054
Khoobchandani M, Katti KK, Karikachery AR, Thipe VC, Srisrimal D, Dhurvas Mohandoss DK, Darshakumar RD, Joshi CM, Katti KV (2020) New approaches in breast cancer therapy through green nanotechnology and nano-ayurvedic medicine – pre-clinical and pilot human clinical investigations. Int J Nanomedicine 15:181–197. https://doi.org/10.2147/IJN.S219042
Khoobchandani M, Khan A, Katti KK, Thipe VC, Al-Yasiri AY, MohanDoss DKD, Nicholl MB, Lugão AB, Hans CP, Katti KV (2021) Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy. Sci Rep 11(1):16797. https://doi.org/10.1038/s41598-021-96224-8
Kim J-K, Seo S-J, Kim H-T, Kim K-H, Chung M-H, Kim K-R, Ye S-J (2012) Enhanced proton treatment in mouse tumors through proton irradiated nanoradiator effects on metallic nanoparticles. Phys Med Biol 57(24):8309–8323. https://doi.org/10.1088/0031-9155/57/24/8309
Lamichhane, S., & Lee, S. (2020). Albumin nanoscience: homing nanotechnology enabling targeted drug delivery and therapy. In Arch Pharm Res (43, 1, pp. 118–133). https://doi.org/10.1007/s12272-020-01204-7. Pharmaceutical Society of Korea
Levitt DG, Levitt MD (2016) Human serum albumin homeostasis: A new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. Int J General Med 9:229–255. https://doi.org/10.2147/IJGM.S102819. Dove Medical Press Ltd
Ma J, Wang F, Mostafavi M (2018) Ultrafast chemistry of water radical cation, H2O•+, in aqueous solutions. Molecules 23(2). https://doi.org/10.3390/molecules23020244
Matusiak M, Kadlubowski S, Ulanski P (2018) Radiation-induced synthesis of poly(acrylic acid) nanogels. Radiat Phys Chem 142:125–129. https://doi.org/10.1016/j.radphyschem.2017.01.037
Maziero JS, Thipe VC, Rogero SO, Cavalcante AK, Damasceno KC, Ormenio MB, Martini GA, Batista JGS, Viveiros W, Katti KK, Karikachery AR, Mohandoss DD, Dhurvas RD, Nappinnai M, Rogero JR, Lugão AB, Katti KV (2020) Species-specific in vitro and in vivo evaluation of toxicity of silver nanoparticles stabilized with gum Arabic protein. Int J Nanomedicine 15:7359–7376. https://doi.org/10.2147/IJN.S250467
Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R (2017) Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun 8(May):1–13. https://doi.org/10.1038/ncomms15906
Neamtu I, Rusu AG, Diaconu A, Nita LE, Chiriac AP (2017) Basic concepts and recent advances in nanogels as carriers for medical applications. In. Drug Deliv 24(1). https://doi.org/10.1080/10717544.2016.1276232
Ni K, Lan G, Lin W (2020) Nanoscale metal–organic frameworks generate reactive oxygen species for cancer therapy. ACS Central Sci 6(6):861–868. https://doi.org/10.1021/acscentsci.0c00397
Paredes KO, Ruiz-Cabello J, Alarcón DI, Filice M (2019) The state of the art of investigational and approved nanomedicine products for nucleic acid delivery. In: Nucleic acid nanotheranostics: biomedical applications. Elsevier, pp 421–456. https://doi.org/10.1016/B978-0-12-814470-1.00015-0
Parodi A, Miao J, Soond SM, Rudzińska M, Zamyatnin AA Jr (2019) Albumin nanovectors in cancer therapy and imaging. Biomol Ther 9(6):218. https://doi.org/10.3390/biom9060218
Persico MG, Marenco M, De Matteis G, Manfrinato G, Cavenaghi G, Sgarella A, Aprile C, Lodola L (2020) 99mTc-68Ga-ICG-labelled macroaggregates and nanocolloids of human serum albumin: synthesis procedures of a trimodal imaging agent using commercial kits. Contrast Media & Molecular Imaging, 2020, 3629705. https://doi.org/10.1155/2020/3629705
Pinals RL, Yang D, Rosenberg DJ, Chaudhary T, Crothers AR, Iavarone AT, Hammel M, Landry MP (2020) Protein corona composition and dynamics on carbon nanotubes in blood plasma and cerebrospinal fluid. BioRxiv, 2020.01.13.905356. https://doi.org/10.1101/2020.01.13.905356
Piroonpan T, Katemake P, Pasanphan W (2020) Comparative study of different chitosan solutions to assist the green synthesis of gold nanoparticles under irradiation. Radiat Phys Chem 169:108250. https://doi.org/10.1016/j.radphyschem.2019.03.054
Queiroz RG, Varca GHC, Kadlubowski S, Ulanski P, Lugão AB (2016) Radiation-synthesized protein-based drug carriers: size-controlled BSA nanoparticles. Int J Biol Macromol 85:82–91. https://doi.org/10.1016/j.ijbiomac.2015.12.074
Santos JJ, Leal J, Dias LAP, Toma SH, Corio P, Genezini FA, Katti KV, Araki K, Lugão AB (2018) Bovine serum albumin conjugated Gold-198 nanoparticles as model to evaluate damage caused by ionizing radiation to biomolecules. ACS Appl Nano Mater 1(9):5062–5070. https://doi.org/10.1021/acsanm.8b01174
Seniwal B, Freitas LF, Mendes BM, Lugão AB, Katti KV, Fonseca TCF (2021) In silico dosimetry of low-dose rate brachytherapy using radioactive nanoparticles. Phys Med Biol 66(4):045016. https://doi.org/10.1088/1361-6560/abd671
Shukla R, Chanda N, Zambre A, Upendran A, Katti K, Kulkarni RR, Nune SK, Casteel SW, Smith CJ, Vimal J, Boote E, Robertson JD, Kan P, Engelbrecht H, Watkinson LD, Carmack TL, Lever JR, Cutler CS, Caldwell C, … Katti KV (2012) Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer. Proc Natl Acad Sci 109(31):12426–12431. https://doi.org/10.1073/pnas.1121174109
Siri M, Ruocco MJF, Achilli E, Pizzuto M, Delgado JF, Ruysschaert JM, Grasselli M, Alonso, S. del V (2019) Effect of structure in ionised albumin based nanoparticle: characterisation, Emodin interaction, and in vitro cytotoxicity. Mater Sci Eng C 103:109813. https://doi.org/10.1016/j.msec.2019.109813
Tangthong T, Piroonpan T, Thipe VC, Khoobchandani M, Katti K, Katti KV, Pasanphan W (2021) Water-soluble chitosan conjugated DOTA-bombesin peptide capped gold nanoparticles as a targeted therapeutic agent for prostate cancer. Nanotechnol Sci Appl 14:69–89. https://doi.org/10.2147/NSA.S301942
Thipe VC, Panjtan Amiri K, Bloebaum P, Raphael Karikachery A, Khoobchandani M, Katti KK, Jurisson SS, Katti KV (2019) Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers. Int J Nanomedicine 14:4413–4428. https://doi.org/10.2147/IJN.S204443
Tipnis NP, Burgess DJ (2018) Sterilization of implantable polymer-based medical devices: a review. Int J Pharm 544(2):455–460. https://doi.org/10.1016/j.ijpharm.2017.12.003
Varca GHC, Queiroz RG, Lugão AB (2016) Irradiation as an alternative route for protein crosslinking: cosolvent free BSA nanoparticles. Radiat Phys Chem 124:111–115. https://doi.org/10.1016/j.radphyschem.2016.01.021
Voci S, Gagliardi A, Fresta M, Cosco D (2020) Antitumor features of vegetal protein-based nanotherapeutics. Pharmaceutics 12(1). https://doi.org/10.3390/pharmaceutics12010065. MDPI AG
Zhou W, Yang G, Ni X, Diao S, Xie C (2020) Recent advances in crosslinked nanogel for multimodal imaging and cancer therapy. Polymers (Basel) 12(9). https://doi.org/10.3390/polym12091902
Acknowledgments
The authors would like to thank the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Grant No. 2019/15154-0 for support to Velaphi Clement Thipe.
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Thipe, V.C. et al. (2022). Fabrication of Green Nanomaterials: Biomedical Applications and Ecotoxicology. In: Shanker, U., Hussain, C.M., Rani, M. (eds) Handbook of Green and Sustainable Nanotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-69023-6_2-1
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