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Are Dietary Extracellular Vesicles Bioavailable and Functional in Consuming Organisms?

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New Frontiers: Extracellular Vesicles

Part of the book series: Subcellular Biochemistry ((SCBI,volume 97))

Abstract

It has been well established that diet influences the health status of the consuming organism. Recently, extracellular vesicles (EVs) present in dietary sources are proposed to be involved in cross-species and kingdom communication. As EVs contain a lipid bilayer and carry bioactive cargo of proteins and nucleic acids, they are proposed to survive harsh degrading conditions of the gut and enter systemic circulation. Following the bioavailability, several studies have supported the functional role of dietary EVs in various tissues of the consuming organism. Simultaneously, multiple studies have refuted the possibility that dietary EVs mediate cross-species communication and hence the topic is controversial. The feasibility of the concept remains under scrutiny primarily owing to the lack of significant in vivo evidence to complement the in vitro speculations. Concerns surrounding EV stability in the harsh degrading gut environment, lack of mechanism explaining intestinal uptake and bioavailability in systemic circulation have impeded the acceptance of their functional role. This chapter discusses the current evidences that support dietary EV-based cross species communication and enlists several issues that need to be addressed in this field.

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  1. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

    Rahul Sanwlani, Pamali Fonseka & Suresh Mathivanan

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  1. Rahul Sanwlani
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  2. Pamali Fonseka
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  3. Suresh Mathivanan
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Correspondence to Suresh Mathivanan .

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  1. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Suresh Mathivanan

  2. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Pamali Fonseka

  3. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Christina Nedeva

  4. Department of Biochemistry and Genetics La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Ishara Atukorala

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Sanwlani, R., Fonseka, P., Mathivanan, S. (2021). Are Dietary Extracellular Vesicles Bioavailable and Functional in Consuming Organisms?. In: Mathivanan, S., Fonseka, P., Nedeva, C., Atukorala, I. (eds) New Frontiers: Extracellular Vesicles. Subcellular Biochemistry, vol 97. Springer, Cham. https://doi.org/10.1007/978-3-030-67171-6_21

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