Abstract
Vessel size imaging (VSI) was required an intravascular superparamagnetic contrast agent for vessel diameter estimation. Apparent diffusion coefficient (ADC) calculated from single refocused pulsed-gradient spin-echo (SRSE-DWI) was influenced by the magnetic susceptibility of vasculature. The influence of the ADC from the vessels can be reduced by using twice refocused spin-echo (TRSE-DWI) sequence. We evaluate the VSI with SRSE-DWI and TRSE-DWI using Monte-Carlo simulations in a vascular model. It was also evaluated in nine patients with cerebral infarction in the penetrating branch area within two weeks after stroke onset. The simulation results show that vessel radius was determined uniquely from the pair of SRSE-DWI and TRSE-DWI signal. Clinical images also suggested the vasodilation in the periphery of cerebral infarction might be detected in the difference image of SRSE-DWI and TRSE-DWI. It suggests that vessel radius might be estimated by acquiring SRSE-DWI and TRSE-DWI. It could be useful for the clinical diagnosis.
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Nakamura, K., Minakata, S., Toyoshima, H., Kinoshita, T. (2021). Monte-Carlo Simulation and Clinical Image Validation for Vessel Size Imaging with Twice and Single Refocus Spin-Echo Diffusion Sequence. In: Shiraishi, Y., Sakuma, I., Naruse, K., Ueno, A. (eds) 11th Asian-Pacific Conference on Medical and Biological Engineering. APCMBE 2020. IFMBE Proceedings, vol 82. Springer, Cham. https://doi.org/10.1007/978-3-030-66169-4_2
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DOI: https://doi.org/10.1007/978-3-030-66169-4_2
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