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Hyperaldosteronism

  • Reference work entry
  • First Online:
Endocrine Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 5 Accesses

Synonyms

Conn’s syndrome

Definition

Hyperaldosteronism is a clinical condition characterized by hypertension due to unregulated increase of aldosterone secretion, which in most of the cases is associated with hypokalemia. The increased secretion of aldosterone determines renal potassium excretion and reabsorption of sodium with consequent water retention and plasma volume expansion.

Clinical Features

  • Incidence

    Primary hyperaldosteronism is the most frequent cause of secondary hypertension with an estimated incidence of 6–20% in adult patients with hypertension. The estimated prevalence is 5–10% of all patients with hypertension. The prevalence can reach 30% if the aldosterone to renin ratio is used as a screening method to detect the disease.

  • Age

    The diagnosis of primary hyperaldosteronism is usually made in patients who are in the third to sixth decade of life.

  • Sex

    The disease is two times more common in women than in men.

  • Site

    Most cases of primary hyperaldosteronism are caused by...

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References and Further Reading

  • El-Asmar, N., Rajpal, A., & Arafah, B. M. (2021). Primary hyperaldosteronism: Approach to diagnosis and management. The Medical Clinics of North America, 105, 1065–1080.

    Article  PubMed  Google Scholar 

  • Funder, J. W., Carey, R. M., Mantero, F., et al. (2016). The management of primary aldosteronism: Case detection, diagnosis, and treatment: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 101, 1889–1916.

    Article  CAS  PubMed  Google Scholar 

  • Gomez-Sanchez, C. E., Qi, X., Velarde-Miranda, C., et al. (2014). Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Molecular and Cellular Endocrinology, 383, 111–117.

    Article  CAS  PubMed  Google Scholar 

  • Karwacka, I., Obołończyk, Ł., Kaniuka-Jakubowska, S., Bohdan, M., & Sworczak, K. (2021). Progress on genetic basis of primary aldosteronism. Biomedicine, 9, 1708.

    CAS  Google Scholar 

  • Schilbach, K., Junnila, R. K., & Bidlingmaier, M. (2019). Aldosterone to renin ratio as screening tool in primary aldosteronism. Experimental and Clinical Endocrinology & Diabetes, 127, 84–92.

    Article  CAS  Google Scholar 

  • Williams, T. A., & Reincke, M. (2022). Pathophysiology and histopathology of primary aldosteronism. Trends in Endocrinology and Metabolism, 33, 36–49.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pathology, University Hospital and University of Lausanne, Lausanne, Switzerland

    Stefano La Rosa

  2. Pathology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy

    Stefano La Rosa

Authors
  1. Stefano La Rosa
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Corresponding author

Correspondence to Stefano La Rosa .

Editor information

Editors and Affiliations

  1. University of Insubria, Varese, Italy

    Stefano La Rosa

  2. Department of Medicine and Surgery, Unit of Pathology, University of Insubria, Varese, Italy

    Silvia Uccella

  3. Department of Biomedical Sciences, Humanitas University and Service of Pathology, Humanitas Research Hospital, Milan, Italy

    Silvia Uccella

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Cite this entry

La Rosa, S. (2022). Hyperaldosteronism. In: La Rosa, S., Uccella, S. (eds) Endocrine Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-62345-6_5250

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  • DOI: https://doi.org/10.1007/978-3-030-62345-6_5250

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-62344-9

  • Online ISBN: 978-3-030-62345-6

  • eBook Packages: MedicineReference Module Medicine

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