Synonyms
Papillary adenocarcinoma
Definition
Papillary carcinoma is a malignant follicular cell-derived neoplasm defined by a set of distinctive nuclear features, including (1) chromatin characteristics: e.g., chromatin clearing, margination, and glassy nuclei; (2) nuclear membrane irregularity: e.g., irregular nuclear contour, nuclear grooves, and nuclear pseudoinclusions; and (3) change in nuclear size and shape: e.g., nuclear elongation, enlargement, and overlapping (Fig. 1).
Nuclear features of papillary carcinoma. The nuclei show chromatin margination, nuclear membrane irregularity, and frequent nuclear pseudoinclusions (arrows). The nuclear pseudoinclusion represents invagination of cytoplasm into the nuclei, giving rise to an eosinophilic inclusion with a sharp border
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References and Further Reading
Cancer Genome Atlas Research, N. (2014). Integrated genomic characterization of papillary thyroid carcinoma. Cell, 159(3), 676–690. https://doi.org/10.1016/j.cell.2014.09.050.
Ganly, I., Ibrahimpasic, T., Rivera, M., Nixon, I., Palmer, F., Patel, S. G., et al. (2014). Prognostic implications of papillary thyroid carcinoma with tall-cell features. Thyroid, 24(4), 662–670. https://doi.org/10.1089/thy.2013.0503.
Ghossein, R., & Livolsi, V. A. (2008). Papillary thyroid carcinoma tall cell variant. Thyroid, 18(11), 1179–1181. https://doi.org/10.1089/thy.2008.0164.
Haugen, B. R. M., Alexander, E. K., Bible, K. C., Doherty, G., Mandel, S. J., Nikiforov, Y. E., et al. (2016). 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 26, 1–133. https://doi.org/10.1089/thy.2015.0020.
Lloyd, R. V., Osamura, R. Y., Kloppel, G., & Rosai, J. (2017). WHO classification of tumours of endocrine organs (eds.: R. V. Lloyd, R. Y. Osamura, G. Kloppel, & J. Rosai). Lyon: International Agency for Research on Cancer (IARC).
Nikiforov, Y. E., Seethala, R. R., Tallini, G., Baloch, Z. W., Basolo, F., Thompson, L. D., et al. (2016). Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: A paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncology, 2(8), 1023–1029. https://doi.org/10.1001/jamaoncol.2016.0386.
Siegel, R. L., Miller, K. D., & Jemal, A. (2018). Cancer statistics, 2018. CA: a Cancer Journal for Clinicians, 68(1), 7–30. https://doi.org/10.3322/caac.21442.
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Xu, B., Ghossein, R. (2022). Papillary Carcinoma. In: La Rosa, S., Uccella, S. (eds) Endocrine Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-62345-6_5157
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