Definition and Synonyms
The name Histamine (H) indicates an amine (specifically the imidazolethylamine) present in tissues (Haas et al. 2008). H is derived from the amino acid histidine by an enzymatic conversion through the histidine decarboxylase. From the discovery in the first part of the twentieth century (was purified from ergot fungi in 1910 and subsequently from human tissues; Huang et al. 2018), and for a long time, histamine was considered a local hormone released by mast cells during the inflammatory reaction; subsequently, it became recognized as a transmitter in invertebrates and in the vertebrate brain, where histaminergic neurons are localized (Huang et al. 2018). As hormone, H plays a key role in several functions such as the control of gastric acid secretion, immunomodulation, contraction in bronchial muscle cells or vasodilatation, or the control of endothelial barrier permeability. The highest concentrations of histamine are found in the lung, the skin, and the...
References and Further Reading
Barcik, W., Wawrzyniak, M., Akdis, C. A., & O'Mahony, L. (2017). Immune regulation by histamine and histamine-secreting bacteria. Current Opinion in Immunology, 48, 108–113.
Cosentino, M., & Marino, F. (2018). Neural regulation of inflammation: Pharmacological mechanisms and therapeutic perspectives. In C. Ricciardi, F. Levi-Schaffer, & E. Tiligada (Eds.), Immunopharmacology and inflammation (pp. 107–130). Springer.
Haas, H. I., Sergeeva, O. A., & Selbach, O. (2008). Histamine in the central nervous system. Physiological Reviews, 88, 1183–1241.
Hua Huang, H., Li, Y., Jinyi Liang, J., & Finkelman, F. D. (2018). Molecular regulation of histamine synthesis. Frontiers in Immunology, 9, 1392.
Johansson, M., Henriksson, R., Bergenheim, A. T., & Koskinen, L. O. (2000). Interleukin-2 and histamine in combination inhibit tumour growth and angiogenesis in malignant glioma. British Journal of Cancer, 83, 826–832.
Medina, V., Croci, M., Crescenti, E., Mohamad, N., Sanchez-Jiménez, F., Massari, N., Nuñez, M., Cricco, G., Martin, G., Bergoc, R., & Rivera, E. (2008). The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment. Cancer Biology & Therapy, 7, 28–35.
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Cosentino, M., Marino, F. (2022). Histamine Receptors. In: La Rosa, S., Uccella, S. (eds) Endocrine Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-62345-6_5128
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DOI: https://doi.org/10.1007/978-3-030-62345-6_5128
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