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Invasive Candidiasis in Surgical Patients

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Infections in Surgery

Part of the book series: Hot Topics in Acute Care Surgery and Trauma ((HTACST))

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Abstract

Invasive and disseminated Candida infections have become a major source of morbidity and mortality in neutropenic and nonneutropenic surgical intensive care patients. The incidence of Candida has increased: it is now the fourth most often isolated pathogen in bloodstream infections. After extended intraabdominal surgery and especially in emergency intraabdominal infection the abdomen is the predominant focus for candida infection. Intraabdominal candidiasis (IAC) is the predominant type of invasive candidiasis after candidemia. IAC is associated with mortality rates around 25–60%. Some studies have demonstrated almost a double mortality rate (48% versus 28%) in critically ill surgical patients with nosocomial fungal peritonitis compared to those without fungal infection. The diagnosis of postoperative candida infections is difficult because clinical signs and laboratory findings are unspecific. The decisive factors for a favorable outcome of infected patients are early diagnosis, adequate source control, as well as a prompt and appropriate anti-infective therapy.

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  1. Emergency Surgery and Trauma, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

    Sganga Gabriele, Fransvea Pietro, Pepe Gilda, Di Grezia Marta & Cozza Valerio

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  1. Sganga Gabriele
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  2. Fransvea Pietro
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  4. Di Grezia Marta
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  5. Cozza Valerio
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Correspondence to Sganga Gabriele .

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  1. Department of Surgery, Macerata Hospital, Macerata, Italy

    Massimo Sartelli

  2. Comparative Effectiveness and Clinical Outcomes Research Center - CECORC, Riverside University Health System Medical Center, Moreno Valley, CA, USA

    Raul Coimbra

  3. Department of infectious diseases, Ospedale di Bolzano, Bolzano, Italy

    Leonardo Pagani

  4. Department of Surgery, Anadolu Medical Centre, Kocaeli, Turkey

    Kemal Rasa

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Gabriele, S., Pietro, F., Gilda, P., Marta, D.G., Valerio, C. (2021). Invasive Candidiasis in Surgical Patients. In: Sartelli, M., Coimbra, R., Pagani, L., Rasa, K. (eds) Infections in Surgery. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-030-62116-2_20

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