Abstract
CD8 marker is not unique to primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (pc CD8+ AECTCL). Moreover, it occurs in seven other entities presented in the following table. There is a certain clinical and morphological overlap of γδ-positive and CD8-positive cases. Due to various aberrant expression of CD56, TCRγ, and CD8 markers, it was suggested that the term “primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphoma” without specification may be better suited for those lymphomas. There is a range of CD8+ pseudolymphomas and CD8+ non-lymphomatous proliferations should be kept on a list of differential diagnosis such as actinic reticuloid, CD8+ drug-associated eruptions, and HIV-associated CD8+ LPD.
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Feldman, T. (2021). Case 35. CD8+ T-cell lymphoma with cytotoxic phenotype. In: Akilov, O.E. (eds) Cutaneous Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-030-59129-8_35
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DOI: https://doi.org/10.1007/978-3-030-59129-8_35
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