Skip to main content

The Molecular Basis of Muscle Invasive Bladder Cancer

  • Chapter
  • First Online:
Management of Muscle Invasive Bladder Cancer

Part of the book series: Management of Urology ((MU))

  • 438 Accesses

Abstract

A systematic review relating to muscle invasive bladder cancer and was conducted. This was to identify the molecular basis of muscle invasive disease. The search strategy aimed to identify all references related to bladder cancer AND muscle invasive disease AND molecular basis. Search terms used were as follows: (Bladder cancer) AND (muscle invasive disease) AND (Molecular Basis). The following databases were screened from 1989 to June 2020. The Molecular Basis of Bladder Cancer—Precision Diagnostics and Treatment, PIK3CA Mutations in Muscle Invasive Bladder Cancer, Epidermal Growth Factor in Muscle Invasive Bladder Cancer, P53, pRB and RAS in Muscle Invasive Bladder Cancer, Transcriptome Profiling in Muscle Invasive Bladder Cancer, Methylation Status in Bladder Cancer, The Cancer Genome Project and the Molecular Basis of Bladder Cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Moher D, Liberati A, Tetzlaff J, Altman DG. “Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The Prisma Statement.” [In English]. BMJ (Online) 339, no. 7716 (08 Aug 2009):332–36.

    Google Scholar 

  2. Mays N, Pope C, Popay J. “Systematically Reviewing Qualitative and Quantitative Evidence to Inform Management and Policy-Making in the Health Field.” [In English]. Journal of Health Services Research and Policy 10, no. SUPPL. 1 (July 2005):6–20.

    Google Scholar 

  3. Su H, Jiang H, Tao T, Kang X, Zhang X, Kang D, Li S, Li C, Wang H, Yang Z, Zhang J, Li C. Hope and challenge: precision medicine in bladder cancer. Cancer Med. 2019;8(4):1806–16.

    Article  Google Scholar 

  4. Sjödahl G, Jackson CL, Bartlett JM, Siemens DR, Berman DM. Molecular profiling in muscle-invasive bladder cancer: more than the sum of its parts. J Pathol. 2019;247(5):563–73.

    Article  Google Scholar 

  5. Borcoman E, De La Rochere P, Richer W, Vacher S, Chemlali W, Krucker C, Sirab N, Radvanyi F, Allory Y, Pignot G, Barry de Longchamps N, Damotte D, Meseure D, Sedlik C, Bieche I, Piaggio E. Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer. Oncoimmunology. 2019;8(5):e1581556.

    Article  Google Scholar 

  6. Smith K, Fennelly JA, Neal DE, Hall RR, Harris AL. Characterization and quantitation of the epidermal growth factor receptor in invasive and superficial bladder tumors. Cancer Res. 1989;49(21):5810–5.

    CAS  PubMed  Google Scholar 

  7. Al Hussain TO, Akhtar M. Molecular basis of urinary bladder cancer. Adv Anat Pathol. 2013;20(1):53–60.

    Article  Google Scholar 

  8. Zhang S, Liu Y, Liu Z, Zhang C, Cao H, Ye Y, Wang S, Zhang Y, Xiao S, Yang P, Li J, Bai Z. Transcriptome profiling of a multiple recurrent muscle-invasive urothelial carcinoma of the bladder by deep sequencing. PLoS One. 2014;9(3):e91466.

    Article  Google Scholar 

  9. Beukers W, Kandimalla R, Masius RG, Vermeij M, Kranse R, van Leenders GJ, Zwarthoff EC. Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer. Mod Pathol. 2015;28(4):515–22.

    Article  CAS  Google Scholar 

  10. Creighton CJ. The clinical applications of The Cancer Genome Atlas project for bladder cancer. Expert Rev Anticancer Ther. 2018;18(10):973–80.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Goonewardene, S.S., Ventii, K., Bahl, A., Persad, R., Motiwala, H., Albala, D. (2021). The Molecular Basis of Muscle Invasive Bladder Cancer. In: Management of Muscle Invasive Bladder Cancer. Management of Urology. Springer, Cham. https://doi.org/10.1007/978-3-030-57915-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-57915-9_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-57914-2

  • Online ISBN: 978-3-030-57915-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics