Definition
Hyperuricemia is a condition characterized by abnormally elevated levels of serum urate (sUA), while gout, the most common form of inflammatory arthritis, arises from the subsequent deposition of urate crystals when concentrations become saturated (Dalbeth et al. 2019).
Hyperuricemia is commonly defined as a serum urate concentration >6.8 mg/dL, based on the in vivo solubility of urate above which crystal deposition may occur leading to gout. It should be noted that alternative definitions of hyperuricemia are sometimes applied, which needs to be considered during comparative data analysis (Stamp and Dalbeth 2017).
Gout has been defined as “a progressive metabolic disease characterized by symptomatic hyperuricemia and deposition of monosodium urate (MSU) crystals in joints and soft tissues due to an imbalance in uric acid uptake, synthesis or excretion” (Bardin and Richette 2014). Not all individuals with hyperuricemia go on to develop gout, and...
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References
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Benn, C. (2021). Physiology and Treatment of Hyperuricemia and Gout. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-57401-7_10042
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