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An Update on Mendelian Forms of Obesity and their Personalized Treatments

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Obesity and Diabetes

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Abstract

Obesity has a strong inherited component (40–75% of the risk is driven by genetic factors), including monogenic syndromic or not, oligogenic, and polygenic modalities. Monogenic nonsyndromic/oligogenic genes in the leptin-melanocortin pathway are analyzed, as well as their role in energy balance. Early genetic testing along with traditional and ongoing attempts to clinically handle several relevant categories is similarly addressed.

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Funding Sources

DM holds a Canada Research Chair in Genetics of Obesity.

Declarations of Interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada

    Selene Chen & David Meyre

  2. Michael DeGroote Centre for Learning & Discovery, McMaster University, Hamilton, ON, Canada

    David Meyre

  3. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada

    David Meyre

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  1. Selene Chen
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  2. David Meyre
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Correspondence to David Meyre .

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Editors and Affiliations

  1. Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil

    Joel Faintuch

  2. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Salomão Faintuch

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Chen, S., Meyre, D. (2020). An Update on Mendelian Forms of Obesity and their Personalized Treatments. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-53370-0_16

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