Abstract
Non-human primates (NHP) have played a crucial rule in the history of morbillivirus research. Although NHPs are naturally susceptible to morbillivirus infections, outbreaks are rare among monkeys and apes living in their natural habitat. However, introduction of a highly contagious morbillivirus in a high-density population or captive colony seronegative for morbilliviruses can easily lead to an efficient transmission chain in which all animals become infected. Secondary infections due to morbillivirus-induced immune suppression can subsequently yield complications, leading to outbreaks with high morbidity and mortality. In this chapter, we provide an overview of morbillivirus outbreaks that have occurred in different monkey species, and we discuss morbillivirus epidemiology in different target species. Furthermore, differences in infection course and severity in various species are discussed. In addition to discussing natural infection of NHP with morbilliviruses, this chapter provides an overview of experimental infections of NHP with wildtype or genetically engineered morbilliviruses. These studies have contributed significantly to a more complete understanding of measles pathogenesis.
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de Vries, R.D., Kuiken, T., de Swart, R.L. (2020). Morbillivirus Infections in Non-human Primates: From Humans to Monkeys and Back Again. In: Knauf, S., Jones-Engel, L. (eds) Neglected Diseases in Monkeys. Springer, Cham. https://doi.org/10.1007/978-3-030-52283-4_9
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