Abstract
Reduction of aldehydes or ketones to the corresponding methylene compounds using amalgamated zinc in hydrochloric acid.
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Clemmensen, E. Ber. 1913, 46, 1837−1843. Erik C. Clemmensen (1876−1941) was born in Odense, Denmark. He received the M.S. degree from the Royal Polytechnic Institute in Copenhagen. In 1900, Clemmensen immigrated to the United States, and worked at Parke, Davis and Company in Detroit (coincidently, this author′s first employer!) as a research chemist for 14 years, where he discovered the reduction of carbonyl compounds with amalgamated zinc. Clemmensen later founded a few chemical companies and was the president of one of them, the Clemmensen Chemical Corporation in Newark, New Jersey.
Martin, E. L. Org. React. 1942, 1, 155−209. (Review).
Vedejs, E. Org. React. 1975, 22, 401−422. (Review).
Talpatra, S. K.; Chakrabarti, S.; Mallik, A. K.; Talapatra, B. Tetrahedron 1990, 46, 6047−6052.
Martins, F. J. C.; Viljoen, A. M.; Coetzee, M.; Fourie, L.; Wessels, P. L. Tetrahedron 1991, 47, 9215−9224.
Naruse, M.; Aoyagi, S.; Kibayashi, C. J. Chem. Soc., Perkin Trans. 1 1996, 1113−1124.
Alessandrini, L.; et al. Steroids 2004, 69, 789−794.
Dey, S. P.; et al. J. Indian Chem. Soc. 2008, 85, 717−720.
Xu, S.; Toyama, T.; Nakamura, J.; Arimoto, H. Tetrahedron Let. 2010, 51, 4534−4537.
Zhang, J.; Wang, Y.-Q.; Wang, X.-W.; Li, W.-D. Z. J. Org. Chem. 2013, 78, 6154–6162.
Cao, J.; Perlmutter, P. Org. Lett. 2015, 15, 4327–4329.
Suzuki, T.; Okuyama, H.; Takano, A.; Suzuki, S.; Shimizu, I.; Kobayashi, S. J. Org. Chem. 2014, 79, 2803−2808.
Sanchez-Viesca, F.; Berros, M.; Gomez, R. Am. J. Chem. 2018, 8, 8−12.
Oyama, K.-i.; Kimura, Y.; Iuchi, S.; Koga, N.; Yoshida, K.; Kondo, T. RSC Adv. 2019, 9, 31435−31439.
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Li, J.J. (2021). Clemmensen Reduction. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-030-50865-4_31
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