Antibiotic Therapy and Its Effect on Gut Microbiome in Obesity and Weight Loss

Bonilla-Carrero, Paola I.; Mader, Hannah; Meier, Nathan; Olivas, Isis; Boyle, Bridget; Bonilla-Carrero, P.

doi:10.1007/978-3-030-47384-6_10

Paola I. Bonilla-Carrero³,
Hannah Mader³,
Nathan Meier³,
Isis Olivas³,
Bridget Boyle³ &
…
P. Bonilla-Carrero³

1661 Accesses

Abstract

The discovery of antibiotics became a breakthrough in modern medicine as a treatment for what used to be fatal diseases. Nevertheless, years after its development, overuse and misuse of antibiotics have caused long- and short-term effects on individuals. Mainly, the results of antibiotics occur through interactions with the gut microbiome, a central organ with crucial functions involved in an organism’s well-being through biochemical mechanisms. As microorganisms in the gut microbiome undergo exposure to antibiotics, disbalance occurs and gives rise to infections and gastrointestinal issues. A dangerous yet common consequence of gastrointestinal problems is obesity, which has become an epidemic in the United States of America. Obesity affects the homeostasis of the gut microbiota by both diet and antibiotic-induced microbial disbalance. Due to the adverse effects of the incorrect practice of antibiotic therapy, alternatives have been proposed. These include probiotics, phage therapy, fecal transplants, which reduce the impact of aggressive antimicrobials towards the microbes in the gut. It is imperative to find alternative ways and apply them to medical practices to restrict antibiotic associated dysbiosis.

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Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA
Paola I. Bonilla-Carrero, Hannah Mader, Nathan Meier, Isis Olivas, Bridget Boyle & P. Bonilla-Carrero

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Paola I. Bonilla-Carrero
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Isis Olivas
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Department of Animal and Avian Sciences, University of Maryland, College Park, College Park, MD, USA
Debabrata Biswas
Department of Nutrition and Food Science, University of Maryland, College Park, College Park, MD, USA
Shaik O. Rahaman

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Bonilla-Carrero, P.I., Mader, H., Meier, N., Olivas, I., Boyle, B., Bonilla-Carrero, P. (2020). Antibiotic Therapy and Its Effect on Gut Microbiome in Obesity and Weight Loss. In: Biswas, D., Rahaman, S.O. (eds) Gut Microbiome and Its Impact on Health and Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-47384-6_10

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