Abstract
The Hydrogels are tunable three dimensional polymer network attractive for their rich hydrophilicity along with structural similarity with the extracellular matrix that provide a cell proliferation and facilitate rapid cell to cell communication. These Hydrogels are largely focussed by many researchers in the field of medicine due to its capacity to act as scaffold for tissue regeneration, as injectable Hydrogel for sustained drug delivery, in encapsulation of the enzymes and many more. These are prepared by either natural or artificial polymer or both and the nature of selection of polymer depends on its functional characteristics. In this review we reminisce different fabrication techniques and applications of Silk Fibroin (SF) blended with other polymers. SF acts as an attractive class due to excellent mechanical strength, biocompatibility that doesn’t trigger any adverse immunological reaction and manageable biodegradation; in addition this Silk biomaterial has been used for suturing from past many centuries.
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References
A. Sood, M.S. Granick, N.L. Tomaselli, Wound dressings and comparative effectiveness data. Adv. Wound Care (New Rochelle) 3(8), 511–529 (2014)
C.M. Kirschner, K.S. Anseth, Hydrogels in healthcare: from static to dynamic material microenvironments. Acta Mater. 61(3), 931–944 (2013)
I. Gibs, H. Janik, Review: synthetic polymer Hydrogels for biomedical applications. Chem. Chem. Tech. 4, 297–304 (2010)
P. Gunatillake, R. Adhikari, Biodegradable synthetic polymers for tissue engineering. Eur. Cells Mater. 5, 1–16 (2003)
S. Seo, C. Mahapatra, R. Singh, J. Knowles, H. Kim, Strategies for osteochondral repair: focus on scaffolds. J. Tissue Eng. 5, 2041731414541850 (2014)
G.H. Altman, F. Diaz, C. Jakuba, T. Calabro, R.L. Horan, J. Chen, H. Lu, J. Richmond, L. Kaplan, Silk-based biomaterials. Biomaterials 24(3), 401–416 (2003)
Serica Technologies. http://www.sericainc.com/en-us/news/2009
T. Yucel, M.L. Lovett, L. Kaplan, Silk-based biomaterials for sustained drug delivery. J. Control Release 190, 381–397 (2014)
B. Kundu, N. Kurland, S. Banoa, C. Patrac, F. Engel, K. Vamsi, V. Yadavalli, S. Kundu, Silk proteins for biomedical applications: bioengineering perspectives. Prog. Polym. Sci. 39, 251–267 (2014)
S. Bauer, P. Schmuki, K. Von Der Mark, J. Park, Engineering biocompatible implant surfaces part I: materials and surfaces. Prog. Mater Sci. 58, 261–326 (2013)
T. Furuzono, A. Kishida, J. Tanaka, Nano-scaled hydroxyapatite/polymer composite I Coating of sintered hydroxyapatite particles on poly (gamma-methacryloxypropyl trimethoxysilane) grafted Silk Fibroin fibers through chemical bonding. J. Mater. Sci. Mater. Med. 15(1), 19–23 (2004)
Y. Zhang, P. Zhao, Z. Dong, D. Wang, P. Guo, X. Guo, Q. Song, W. Zhang, Q. Xia, Comparative proteome analysis of multi-layer cocoon of the Silkworm, Bombyx mori. PLoS ONE 10(4), e0123403 (2015)
H.J. Jin, D.L. Kaplan, Mechanism of silk processing in insects and spiders. Nature 424(6952), 1057–1061 (2003)
H. Yamada, Y. Igarashi, Y. Takasu, H. Saito, K. Tsubouchi, Identification of Fibroin-derived peptides enhancing the proliferation of cultured human skin fibroblasts. Biomaterials 25(3), 467–472 (2003)
A. Zuluaga-Vélez, D.F. Cómbita-Merchán, R. Buitrago-Sierra, J.F. Santa, E. Aguilar-Fernández, J.C. Sepúlveda-Arias, Silk Fibroin hydrogels from the Colombian silkworm Bombyx mori L: evaluation of physicochemical properties. PLoS ONE 14(3), e0213303 (2019)
U.J. Kim, J. Park, H.J. Kim, M. Wada, D.L. Kaplan, Three-dimensional aqueous-derived biomaterial scaffolds from Silk Fibroin. Biomaterials 26(15), 2775–2785 (2005)
T.D. Gordon, L. Schloesser, D.E. Humphries, M. Spector, Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro. Tissue Eng. 10(7–8), 1287–1295 (2004)
K. Hu, F. Cui, Q. Lv, J. Ma, Q. Feng, L. Xu, D. Fan, Preparation of Fibroin/recombinant human-like collagen scaffold to promote fibroblasts compatibility. J. Biomed. Mater. Res. A 84(2), 483–490 (2008)
Q. Lv, K. Hu, Q. Feng, F. Cui, Fibroin/collagen hybrid Hydrogels with crosslinking method: preparation, properties, and cytocompatibility. J. Biomed. Mater. Res. A 84(1), 198–207 (2008)
P. Chomchalao, S. Pongcharoen, M. Sutheerawattananonda, W. Tiyaboonchai, Fibroin and Fibroin blended three-dimensional scaffolds for rat chondrocyte culture. Biomed. Eng. Online 12, 28 (2013)
S.K. Samal, M. Dash, F. Chiellini, X. Wang, E. Chiellini, H.A. Declercq, D.L. Kaplan, Silk/chitosan biohybrid Hydrogels and scaffolds via green technology. RSC Adv. 4, 53547 (2014)
S. Thomas, Alginate dressings in surgery and wound management—part 3. J. Wound Care 9(4), 163–166 (2000)
K. Ziv, H. Nuhn, Y. Ben-Haim, L.S. Sasportas, P.J. Kempen, T.P. Niedringhaus, M. Hrynyk, R. Sinclair, A.E. Barron, S.S. Gambhir, A tunable Silk-alginate Hydrogel scaffold for stem cell culture and transplantation. Biomaterials 35(12), 3736–3743 (2000)
J. Ming, Z. Jiang, P. Wang, S. Bie, B. Zuo, Silk Fibroin/sodium alginate fibrous Hydrogels regulated hydroxyapatite crystal growth. Mater. Sci. Eng. C 51, 287–293 (2000)
J. Ming, S. Bie, Z. Jiang, P. Wang, B. Zuo, Novel hydroxyapatite nanorods crystal growth in Silk Fibroin/sodium alginate nanofiber Hydrogel. Mater. Lett. 126, 169–173 (2014)
E.S. Gil, D.J. Frankowski, R.J. Spontak, S.M. Hudson, Swelling behavior and morphological evolution of mixed gelatin/Silk Fibroin Hydrogels. Biomacromolecules 6(6), 3079–3087 (2005)
X. Hu, D. Kaplan, Silk biomaterials, in Comprehensive Biomaterials. 207–19 (2011)
J.W. Nichol, S.T. Koshy, H. Bae, C.M. Hwang, S. Yamanlar, A. Khademhosseini, Cell-laden microengineered gelatin methacrylate Hydrogels. Biomaterials 31, 5536–5544 (2010)
H. Aubin, J.W. Nichol, C.B. Hutson, H. Bae, A.L. Sieminski, D.M. Cropek, P. Akhyari, A. Khademhosseini, Directed 3D cell alignment and elongation in microengineered Hydrogels. Biomaterials 31(27), 6941–6951 (2010)
X. Hu, Q. Lu, L. Sun, P. Cebe, X. Wang, X. Zhang, D.L. Kaplan, Biomaterials from ultrasonication-induced Silk Fibroin-hyaluronic acid Hydrogels. Biomacromolecules 11(11), 3178–3188 (2010)
R. Elia, D.R. Newhide, P.D. Pedevillano, G.R. Reiss, M.A. Firpo, E.W. Hsu, D.L. Kaplan, G.D. Prestwich, A. Peattie, Silk-hyaluronan-based composite Hydrogels: a novel, securable vehicle for drug delivery. J. Biomater. Appl. 27(6), 749–762 (2013)
M. Pavlovic, X. Serban, N. Yu, M.J. Manesis, Cross-linked Silk-hyaluronic acid compositions. Google Patents, US Patent App. 13/868,010 (2013)
D. Zhang, K. Chen, L. Wu, D. Wang, S. Ge, Synthesis and characterization of PVA-HA-Silk composite hydrogel by orthogonal experiment. J. Bionic Eng. 9, 234–242 (2012)
T. Suopajärvi, E. Koivuranta, H. Liimatainen, J. Niinimäki, J. Environ. Chem. Eng. 2, 2005–2012 (2014)
H.J. Kim, Y.J. Yang, H.J. Oh, S. Kimura, M. Wada, U.-J. Kim, (Springer, 2017). https://doi.org/10.1007/s10570-017-1491-7
Y. Liu, J. Lim, S.H. Teoh, Review: development of clinically relevant scaffolds for vascularised bone tissue engineering. Biotechnol. Adv. 31(5), 688–705 (2013)
M. Fini, A. Motta, P. Torricelli, G. Giavaresi, N. Nicoli Aldini, M. Tschon, R. Giardino, C. Migliaresi, The healing of confined critical size cancellous defects in the presence of Silk Fibroin Hydrogel. Biomaterials 26(17), 3527–3536 (2005)
M. Samee, S. Kasugai, H. Kondo, K. Ohya, H. Shimokawa, S. Kuroda, Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation. J. Pharmacol. Sci. 108(1), 18–31 (2008)
M. Liu, X. Zeng, C. Ma, H. Yi, Z. Ali, X. Mou, S. Li, Y. Deng, N. He, Injectable Hydrogels for cartilage and bone tissue engineering. Bone Res. 5, 17014 (2017)
F. Mirahmadi, M. Tafazzoli-Shadpour, M.A. Shokrgozar, S. Bonakdar, Enhanced mechanical properties of thermosensitive chitosan Hydrogel by Silk fibers for cartilage tissue engineering. Mater. Sci. Eng. C 33, 4786–4794 (2013)
E.G. Lima, L. Bian, K.W. Ng, R.L. Mauck, B.A. Byers, R.S. Tuan, G.A. Ateshian, C.T. Hung, The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Osteoarthritis Cartilage 15(9), 1025–1033 (2007)
K.D. Kochanek, J. Xu, S.L. Murphy, A.M. Miniño, H.C. Kung, Deaths: final data for 2009. Natl. Vital Stat. Rep. 60(3), 1–116 (2007)
M. Floren, W. Bonani, A. Dharmarajan, A. Motta, C. Migliaresi, W. Tan, Human mesenchymal stem cells cultured on Silk Hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype. Acta Biomater. 31, 156–166 (2016)
W. Sun, T. Incitti, C. Migliaresi, A. Quattrone, S. Casarosa, A. Motta, Genipin-crosslinked gelatin-Silk Fibroin Hydrogels for modulating the behaviour of pluripotent cells. J. Tissue Eng. Regen. Med. 10(10), 876–887 (2016)
C.S. Kim, Y.J. Yang, S.Y. Bahn, H.J. Cha, A bioinspired dual-crosslinked tough Silk protein Hydrogel as a protective biocatalytic matrix for carbon sequestration. NPG Asia Mater. 9, e391 (2017)
C. Yan, A. Altunbas, T. Yucel, R.P. Nagarkar, J.P. Schneider, D.J. Pochan, Injectable solid Hydrogel: mechanism of shear-thinning and immediate recovery of injectable β-hairpin peptide Hydrogels. Soft Matter 6(20), 5143–5156 (2010)
J.Y. Fang, J.P. Chen, Y.L. Leu, H.Y. Wang, Characterization and evaluation of Silk protein Hydrogels for drug delivery. Chem. Pharm. Bull. (Tokyo) 54(2), 156–162 (2006)
Z. Gong, Y. Yang, Q. Ren, X. Chen, Z. Shao, Injectable thixotropic Hydrogel comprising regenerated Silk Fibroin and hydroxypropylcellulose. Soft Matter 8, 2875–2883 (2012)
Z. Ding, H. Han, Z. Fan, H. Lu, Y. Sang, Y. Yao, Q. Cheng, Q. Lu, D.L. Kaplan, Nanoscale Silk–Hydroxyapatite Hydrogels for injectable bone biomaterials. ACS Appl. Mater. Interfaces 16913–16921 (2017)
H.W. Ju, O.J. Lee, B.M. Moon, F.A. Sheikh, J.M. Lee, J.-H. Kim, H.J. Park, D.W. Kim, M.C. Lee, S.H. Kim, C.H. Park, H.R. Lee, Silk Fibroin based Hydrogel for regeneration of burn induced wounds. Tissue Eng. Regenerative Med. 11, 203–210 (2014)
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Sultana, S., Mamatha, D.M., Rahamathulla, S. (2020). Decades of Research and Advancements on Fabrication and Applications of Silk Fibroin Blended Hydrogels. In: Jyothi, S., Mamatha, D., Satapathy, S., Raju, K., Favorskaya, M. (eds) Advances in Computational and Bio-Engineering. CBE 2019. Learning and Analytics in Intelligent Systems, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-030-46939-9_20
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