Abstract
An evolutionary methodology using multiple sequence alignment technique with optimal search algorithms particle swarm optimization and differential evaluation is proposed in this paper. Proposed methodology algorithms are termed as Multiple Sequence Alignment and Particle Swarm Optimization (MSAPSO) and Multiple Sequence Alignment and Differential Evaluation (MSADE). These techniques are developed to categorize gene sequences based on optimal result produced for each generation. These evolutionary techniques encompasses of two phases in designing. In first phase MSA is pragmatic on pair wise sequences to generate aligned sequence as output. The sequence generated as output in the first level will be given as input to second phase. In the second segment optimal search algorithms PSO or DE are applied on sequences which generate optimal value and generation best value for each generation. These values are considered for further categorization. This paper presents analysis of MSAPSO and MSADE on gene sequences.
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Lohitha Lakshmi, K., Bhargavi, P., Jyothi, S. (2020). An Evolutionary Optimization Methodology for Analyzing Breast Cancer Gene Sequences Using MSAPSO and MSADE. In: Jyothi, S., Mamatha, D., Satapathy, S., Raju, K., Favorskaya, M. (eds) Advances in Computational and Bio-Engineering. CBE 2019. Learning and Analytics in Intelligent Systems, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-030-46939-9_2
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