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Extracellular Matrices

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Technology in Practical Dermatology

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Abstract

The skin is the largest organ in our body. The skin plays a barrier role, represents our first defense from toxic, infectious, or mechanical factors and regulates body temperature. It consists of different layers such as epidermis, dermis, and subcutaneous tissue. In the epidermal compartment, keratinocytes are arranged above the basal membrane, in a thin membranous layer composed of proteoglycans, glycoproteins, and collagen. In the dermis, there are two distinct extracellular matrix (ECM) and cell populations. Beneath the basal membrane there is the extracellular dermal matrix containing glycosaminoglycans (GAG), elastin, collagen, and cells like melanocytes, fibroblasts and endothelial cells. Skin wounds may represent a severe risk for patients, if the skin is not repaired and restored within an acceptable time.

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The authors declare no conflict of interest for this chapter.

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Authors and Affiliations

  1. Department of Dermatology, University of Pisa, Pisa, Italy

    Andrea Ingegneri & Marco Romanelli

Authors
  1. Andrea Ingegneri
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  2. Marco Romanelli
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Editors and Affiliations

  1. Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy

    Michele Fimiani

  2. Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy

    Pietro Rubegni

  3. Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy

    Elisa Cinotti

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Ingegneri, A., Romanelli, M. (2020). Extracellular Matrices. In: Fimiani, M., Rubegni, P., Cinotti, E. (eds) Technology in Practical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-45351-0_40

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  • DOI: https://doi.org/10.1007/978-3-030-45351-0_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45350-3

  • Online ISBN: 978-3-030-45351-0

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