Abstract
Livestock breeding is one of the main concerns for animal owners. Progesterone plays a crucial role in regulating the activity of the reproductive system. In the present study, in situ formed systems that include poly(lactic-co-glycolic) acid (PLGA) as a biodegradable polymer, N-methyl-2-pyrrolidone (NMP) as a bioavailable solvent, and sodium chloride (NaCl) as an additive were provided to treat abortion. The release media was selected as a biphasic that contain 1,2-dichloroethane and buffer phosphate (87:13%) at 37 °C. The high-performance liquid chromatography system was also used to determine the amount of drug release. Degradation of systems was determined by examining the process of pH change. In general, it can be concluded that in situ systems based on PLGA containing NMP with 30 wt% sodium chloride salts showed a linear release profile.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Rode, L., Langhoff-Roos, J., Andersson, C.: Acta Obstet. Gynecol. Scand. 88, 1180–1189 (2009)
Ruana, X., Mueck, A.O.: Maturitas, 248–255 (2014)
Haddad, G., Saguan, D.A., Maxwell, R., Thomas, M.A.: J. Assist. Reprod. Genet. 24, 467–470 (2007)
Turino, L.N., Mariano, R.N., Boimvaser, S., Luna, J.A.: J. Pharm. Innov. 9, 132–140 (2014)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Armiun, M., Taghizadeh, S.M., Mobedi, H. (2020). Investigation of In Situ Systems of Progesterone in Biphasic Media. In: Mirzadeh, H., Katbab, A. (eds) Eco-friendly and Smart Polymer Systems. ISPST 2018. Springer, Cham. https://doi.org/10.1007/978-3-030-45085-4_16
Download citation
DOI: https://doi.org/10.1007/978-3-030-45085-4_16
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-45084-7
Online ISBN: 978-3-030-45085-4
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)