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Histomonas meleagridis Molecular Traits—From Past to Future

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Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

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Abstract

The protozoan parasite Histomonas meleagridis is the causative agent of histomonosis, a poultry disease whose significance is underlined by the absence of any licenced prophylaxis or treatment. Considering the parasite-bacteria interplay, histomonosis represents an intriguing interaction in medicine. The present review targets the molecular research on H. meleagridis, covering the period after re-emergence of histomonosis at the beginning of the twenty-first century until today, from early phylogenetic studies to recent investigations applying omics techniques.

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Abbreviations

CP:

cysteine peptidase

FBA:

fructose bisphosphate aldolase

GAPDH:

glyceraldehyde-3-phospate dehydrogenase

MW:

molecular weight

pI:

isoelectric point

TPI:

triosephosphate isomerase

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Acknowledgements

The authors thank all colleagues from the Clinic for Poultry and Fish Medicine and Christian Doppler Laboratory for Innovative Poultry Vaccines (IPOV) at the Vetmeduni Vienna for their unceasing support. Furthermore, the authors want to thank the Austrian Science Fund (FWF) for the substantial funding of the research on H. meleagridis and histomonosis.

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Authors and Affiliations

  1. Clinic for Poultry and Fish Medicine, University of Veterinary Medicine, Vienna, Austria

    Ivana Bilic & Michael Hess

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  1. Ivana Bilic
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  2. Michael Hess
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Correspondence to Ivana Bilic .

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Editors and Affiliations

  1. Institute Pasteur, Paris, France

    Nancy Guillen

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Bilic, I., Hess, M. (2020). Histomonas meleagridis Molecular Traits—From Past to Future. In: Guillen, N. (eds) Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-44826-4_4

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