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PTH Measurement in CKD

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Parathyroid Glands in Chronic Kidney Disease

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Abstract

Parathyroid hormone (PTH) determination remains a challenge, especially in patients suffering from chronic kidney diseases. In this chapter, we will give some insights on different factors that can impact PTH results, either from the pre-analytical, analytical and post-analytical phases. From the pre-analytical phase, we will discuss some issues linked with PTH stability, the importance of sampling site, sampling time and seasonal variation. From the analytical perspectives, we will evoke the issues linked with the different PTH generation assays and the lack of PTH assays standardization. From the post-analytical phase, we will discuss the biological variability of PTH and its impact of the least significant change. Establishment of good reference ranges for PTH is of paramount importance and this will also be discussed. Finally, we will mention the emerging potential problem of PTH oxidation.

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Authors and Affiliations

  1. Department of Clinical Chemistry, University of Liege, CHU de Liege, Domaine du Sart-Tilman, 4000, Liège, Belgium

    Etienne Cavalier

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  1. Etienne Cavalier
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Correspondence to Etienne Cavalier .

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Editors and Affiliations

  1. Internal Medicine - Nephrology, Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania

    Adrian Covic

  2. Renal Unit, Guy's and St Thomas' NHS Foundation Hospital, London, UK

    David Goldsmith

  3. Nephrology-Dialysis Service, AURA Nord Saint Ouen, Saint Ouen, France

    Pablo A. Ureña Torres

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Cavalier, E. (2020). PTH Measurement in CKD. In: Covic, A., Goldsmith, D., Ureña Torres, P. (eds) Parathyroid Glands in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-43769-5_6

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  • DOI: https://doi.org/10.1007/978-3-030-43769-5_6

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  • Publisher Name: Springer, Cham

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