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Application of Repetitive Transcranial Magnetic Stimulation in Tourette Syndrome

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Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences

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Abstract

Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder with a lifetime prevalence of 0.8% and a higher incidence in males. It is characterized by chronic motor and vocal tics that are often preceded by premonitory urges. Although tic symptoms in the majority of children with TS improve during adolescence, adults with persistent illness can experience chronic and severe tics. Behavioral and pharmacological treatments for TS exist. However, approximately one-third of individuals with TS do not benefit from first-line treatments, and several of the most effective medications have significant side effects. Although the etiology of TS is unknown, exploring tic disorders has led to a deeper understanding of neural pathways and circuits in the brain that subserve sensory and motor function, linking the frontal lobes, the striatum, and the thalamus. The emerging knowledge concerning the underlying circuitry of TS has been used to guide the design of focal brain interventions, such as noninvasive brain stimulation, as novel putative treatment strategies. Here is a report about the promising, although preliminary, results of repetitive transcranial magnetic stimulation (rTMS) in the treatment of TS.

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Authors and Affiliations

  1. Department of Cellular, Molecular and Biomedical Sciences, CUNY School of Medicine, City University of New York, New York, NY, USA

    Antonio Mantovani

  2. Department of Medicine and Health Sciences “V. Tiberio”, Molise University, Campobasso, Italy

    Antonio Mantovani

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  1. ASST Fatebenefratelli Sacco, University of Milan, MILANO, Milano, Italy

    Bernardo Dell'Osso

  2. University of Rome Tor Vergata, Roma, Italy

    Giorgio Di Lorenzo

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Mantovani, A. (2020). Application of Repetitive Transcranial Magnetic Stimulation in Tourette Syndrome. In: Dell'Osso, B., Di Lorenzo, G. (eds) Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-43356-7_10

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