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Preclinical SPECT and SPECT-CT in Oncology

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Molecular Imaging in Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 216))

Abstract

Molecular imaging enables both spatial and temporal understanding of the complex biologic systems underlying carcinogenesis and malignant spread. Single-photon emission tomography (SPECT) is a versatile nuclear imaging-based technique with ideal properties to study these processes in vivo in small animal models, as well as to identify potential drug candidates and characterize their antitumor action and potential adverse effects. Small animal SPECT and SPECT-CT (single-photon emission tomography combined with computer tomography) systems continue to evolve, as do the numerous SPECT radiopharmaceutical agents, allowing unprecedented sensitivity and quantitative molecular imaging capabilities. Several of these advances, their specific applications in oncology as well as new areas of exploration are highlighted in this chapter.

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Authors and Affiliations

  1. Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, H2232, MC 5281, Stanford, CA, 94305-5105, USA

    Benjamin L. Franc & Carina Mari Aparici

  2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA

    Youngho Seo & Robert Flavell

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  1. Benjamin L. Franc
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  1. Department of Nuclear Medicine, University of Münster, Münster, Germany

    Otmar Schober

  2. Institute for Experimental Molecular Imaging, University Hospital, RWTH Aachen University, Aachen, Germany

    Fabian Kiessling

  3. Department of Radiation Oncology, Ruprecht Karl University, Heidelberg, Germany

    Jürgen Debus

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Franc, B.L., Seo, Y., Flavell, R., Aparici, C.M. (2020). Preclinical SPECT and SPECT-CT in Oncology. In: Schober, O., Kiessling, F., Debus, J. (eds) Molecular Imaging in Oncology. Recent Results in Cancer Research, vol 216. Springer, Cham. https://doi.org/10.1007/978-3-030-42618-7_11

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