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Bradyarrhythmias

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Management of Cardiac Arrhythmias

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Bradycardia is defined by the National Institutes of Health as a heart rate less than 60 bpm in adults, although many studies use a cutoff of 50 bpm due to the fact that lower heart rates are associated with advancing age. However, the heart rate alone does not define an underlying pathology, as pathologic bradyarrhythmias will present with a combination of slow heart rates and symptoms such as dizziness, fatigue, and syncope that suggest inadequate cardiac output. Pathologic bradycardia can be secondary to impaired impulse initiation, failure of impulse conduction, or a combination of both of these factors. The differential diagnosis is divided based on the anatomic location of the disease, typically consisting of the sinus node and the atrioventricular node. While the causes of bradycardia are vast, the ECG continues to be the most versatile test in diagnosing each of these disorders and is instrumental in the initial workup. Occasionally, additional studies such as exercise testing, pharmacologic therapy, or invasive EP studies are required when the diagnosis remains uncertain.

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References

  1. Christoffels VM, et al. Development of the pacemaker tissues of the heart. Circ Res. 2010;106(2):240–54.

    CAS  PubMed  Google Scholar 

  2. Anderson RH, et al. The anatomy of the cardiac conduction system. Clin Anat. 2009;22(1):99–113.

    PubMed  Google Scholar 

  3. Ho SY, Sanchez-Quintana D. Anatomy and pathology of the sinus node. J Interv Card Electrophysiol. 2016;46(1):3–8.

    PubMed  Google Scholar 

  4. Monfredi O, et al. The anatomy and physiology of the sinoatrial node--a contemporary review. Pacing Clin Electrophysiol. 2010;33(11):1392–406.

    PubMed  Google Scholar 

  5. Fedorov VV, et al. Optical mapping of the isolated coronary-perfused human sinus node. J Am Coll Cardiol. 2010;56(17):1386–94.

    PubMed  PubMed Central  Google Scholar 

  6. Dobrzynski H, et al. Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues. Pharmacol Ther. 2013;139(2):260–88.

    CAS  PubMed  Google Scholar 

  7. Spach MS, et al. Collision of excitation waves in the dog Purkinje system. Extracellular identification. Circ Res. 1971;29(5):499–511.

    CAS  PubMed  Google Scholar 

  8. Li J, et al. Computer three-dimensional reconstruction of the atrioventricular node. Circ Res. 2008;102(8):975–85.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Monfredi O, Maltsev VA, Lakatta EG. Modern concepts concerning the origin of the heartbeat. Physiology (Bethesda). 2013;28(2):74–92.

    CAS  Google Scholar 

  10. Spodick DH, et al. Operational definition of normal sinus heart rate. Am J Cardiol. 1992;69(14):1245–6.

    CAS  PubMed  Google Scholar 

  11. Link MS, et al. Cardiac arrhythmias in the athlete. Cardiol Rev. 2001;9(1):21–30.

    CAS  PubMed  Google Scholar 

  12. Choudhury M, Boyett MR, Morris GM. Biology of the sinus node and its disease. Arrhythmia Electrophysiol Rev. 2015;4(1):28–34.

    Google Scholar 

  13. Bradshaw PJ, et al. Trends in the incidence and prevalence of cardiac pacemaker insertions in an ageing population. Open Heart. 2014;1(1):e000177.

    PubMed  PubMed Central  Google Scholar 

  14. Jensen PN, et al. Incidence of and risk factors for sick sinus syndrome in the general population. J Am Coll Cardiol. 2014;64(6):531–8.

    PubMed  PubMed Central  Google Scholar 

  15. Mond HG, Proclemer A. The 11th world survey of cardiac pacing and implantable cardioverter-defibrillators: calendar year 2009--a World Society of Arrhythmia’s project. Pacing Clin Electrophysiol. 2011;34(8):1013–27.

    PubMed  Google Scholar 

  16. John RM, Kumar S. Sinus node and atrial arrhythmias. Circulation. 2016;133(19):1892–900.

    PubMed  Google Scholar 

  17. Chang HY, et al. Sinus node dysfunction in atrial fibrillation patients: the evidence of regional atrial substrate remodelling. Europace. 2013;15(2):205–11.

    PubMed  Google Scholar 

  18. Stiles MK, Brooks AG, Roberts-Thomson KC, Kuklik P, John B, Young GD, et al. High-density mapping of the sinus node in humans: role of preferential pathways and the effect of remodeling. J Cardiovasc Electrophysiol. 2010;21(5):532–9.

    PubMed  Google Scholar 

  19. Pejković B, Krajnc I, Anderhuber F, Kosutić D. Anatomical aspects of the arterial blood supply to the sinoatrial and atrioventricular nodes of the human heart. J Int Med Res. 2008;36(4):691–8.

    PubMed  Google Scholar 

  20. Senturk T, et al. Cardiac pauses in competitive athletes: a systematic review examining the basis of current practice recommendations. Europace. 2016;18(12):1873–9.

    PubMed  Google Scholar 

  21. Brubaker PH, Kitzman DW. Chronotropic incompetence: causes, consequences, and management. Circulation. 2011;123(9):1010–20.

    PubMed  PubMed Central  Google Scholar 

  22. Gann D, Tolentino A, Samet P. Electrophysiologic evaluation of elderly patients with sinus bradycardia: a long-term follow-up study. Ann Intern Med. 1979;90(1):24–9.

    CAS  PubMed  Google Scholar 

  23. Menozzi C, Brignole M, Alboni P, Boni L, Paparella N, Gaggioli G, et al. The natural course of untreated sick sinus syndrome and identification of the variables predictive of unfavorable outcome. Am J Cardiol. 1998;82(10):1205–9.

    CAS  PubMed  Google Scholar 

  24. Kuo FY, et al. Recurrent syncope due to carotid sinus hypersensitivity and sick sinus syndrome. J Chin Med Assoc. 2008;71(10):532–5.

    PubMed  Google Scholar 

  25. Barra SN, et al. A review on advanced atrioventricular block in young or middle-aged adults. Pacing Clin Electrophysiol. 2012;35(11):1395–405.

    PubMed  Google Scholar 

  26. Brugada J, et al. Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement. Europace. 2013;15(9):1337–82.

    PubMed  Google Scholar 

  27. Kertesz NJ, Fenrich AL, Friedman RA. Congenital complete atrioventricular block. Tex Heart Inst J. 1997;24(4):301–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Lazzerini PE, Capecchi PL, Laghi-Pasini F. Isolated atrioventricular block of unknown origin in adults and anti-Ro/SSA antibodies: clinical evidence, putative mechanisms, and therapeutic implications. Heart Rhythm. 2015;12(2):449–54.

    PubMed  Google Scholar 

  29. Smits JP, Veldkamp MW, Wilde AA. Mechanisms of inherited cardiac conduction disease. Europace. 2005;7(2):122–37.

    PubMed  Google Scholar 

  30. Sumitomo N. Clinical features of long QT syndrome in children. Circ J. 2016;80(3):598–600.

    CAS  PubMed  Google Scholar 

  31. Gang UJ, et al. High-degree atrioventricular block complicating ST-segment elevation myocardial infarction in the era of primary percutaneous coronary intervention. Europace. 2012;14(11):1639–45.

    PubMed  Google Scholar 

  32. Bejar D, et al. Infiltrative cardiomyopathies. Clin Med Insights Cardiol. 2015;9(Suppl 2):29–38.

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Leyva F, Qiu T, McNulty D, Evison F, Marshall H, Gasparini M. Long-term requirement for pacemaker implantation after cardiac valve replacement surgery. Heart Rhythm. 2017;14(4):529–34.

    PubMed  Google Scholar 

  34. Talreja DR, et al. Alcohol septal ablation versus surgical septal myectomy. J Am Coll Cardiol. 2004;44:2329–32.

    PubMed  Google Scholar 

  35. Ream K, et al. Ambulatory rhythm monitoring to detect late high-grade atrioventricular block following transcatheter aortic valve replacement. J Am Coll Cardiol. 2019;73(20):2538–47.

    PubMed  Google Scholar 

  36. Toggweiler S, Kobza R. Pacemaker implantation after transcatheter aortic valve: why is this still happening? J Thorac Dis. 2018;10(Suppl 30):S3614–9.

    PubMed  PubMed Central  Google Scholar 

  37. Hoefman E, Bindels PJE, van Weert HCPM. Efficacy of diagnostic tools for detecting cardiac arrhythmias: systematic literature search. Neth Heart J. 2010;18(11):543–51.

    CAS  PubMed  Google Scholar 

  38. Padmanabhan D, et al. Diagnostic and therapeutic value of implantable loop recorder: a tertiary care center experience. Pacing Clin Electrophysiol. 2019;42(1):38–45.

    PubMed  Google Scholar 

  39. Chicos AB, Kannankeril PJ, Kadish AH, Goldberger JJ. Parasympathetic effects on cardiac electrophysiology during exercise and recovery in patients with left ventricular dysfunction. Am J Physiol Heart Circ Physiol. 2009;297(2):H743–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Katritsis DG, Josephson ME. Electrophysiological testing for the investigation of bradycardias. Arrhythmia Electrophysiol Rev. 2017;6(1):24–8.

    Google Scholar 

  41. Nikolaidou T, Ghosh JM, Clark AL. Outcomes related to first-degree atrioventricular block and therapeutic implications in patients with heart failure. JACC Clin Electrophysiol. 2016;2(2):181–92.

    PubMed  Google Scholar 

  42. Carroz P, Delay D, Girod G. Pseudo-pacemaker syndrome in a young woman with first-degree atrio-ventricular block. Europace. 2009;12(4):594–6.

    PubMed  Google Scholar 

  43. Ishikawa T, et al. Diastolic mitral regurgitation in patients with first-degree atrioventricular block. Pacing Clin Electrophysiol. 1992;15(11 Pt 2):1927–31.

    CAS  PubMed  Google Scholar 

  44. Nielsen JB, et al. Risk of atrial fibrillation as a function of the electrocardiographic PR interval: results from the Copenhagen ECG study. Heart Rhythm. 2013;10(9):1249–56.

    PubMed  Google Scholar 

  45. Kusumoto FM, et al. 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay. J Am Coll Cardiol. 2019;74(7):932–87.

    Google Scholar 

  46. Adlakha A, Shepard JW Jr. Cardiac arrhythmias during normal sleep and in obstructive sleep apnea syndrome. Sleep Med Rev. 1998;2(1):45–60.

    CAS  PubMed  Google Scholar 

  47. Antoniadis AP, et al. Infra-Hisian block as cause of Wenckebach’s phenomenon in an asymptomatic middle-aged man. Europace. 2010;12(6):898–902.

    PubMed  Google Scholar 

  48. Castellanos A, Befeler B, Myerburg RJ. Pseudo AV block produced by concealed extrasystoles arising below the bifurcation of the His bundle. Br Heart J. 1974;36(5):457–61.

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Barold SS, Padeletti L. Mobitz type II second-degree atrioventricular block in athletes: true or false? Br J Sports Med. 2011;45:687–90.

    PubMed  Google Scholar 

  50. Lee S, Wellens HJJ, Josephson ME. Paroxysmal atrioventricular block. Heart Rhythm. 2009;6(8):1229–34.

    PubMed  Google Scholar 

  51. Brignole M, Menozzi C, Moya A, Garcia-Civera R, Mont L, Alvarez M, et al. Mechanism of syncope in patients with bundle branch block and negative electrophysiological test. Circulation. 2001;104(17):2045–50.

    CAS  PubMed  Google Scholar 

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Disclosures

MR reports no relevant disclosures.

AYS reports the following relationships with industry: 1) Research grants to Duke University from Medtronic and Boston Scientific. (All are >10,000 USD.) 2) Honoraria for lectures or consultation from: Biosense-Webster, Boston Scientific, Medtronic, Merit Medical and St. Jude. (All are <10,000 USD.)

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Correspondence to Albert Y. Sun .

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Rehorn, M., Sun, A.Y. (2020). Bradyarrhythmias. In: Yan, GX., Kowey, P., Antzelevitch, C. (eds) Management of Cardiac Arrhythmias. Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-030-41967-7_9

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  • DOI: https://doi.org/10.1007/978-3-030-41967-7_9

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  • Publisher Name: Humana, Cham

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  • Online ISBN: 978-3-030-41967-7

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