Skip to main content

Adult ADHD in Trauma- and Stressor-Related Disorders

  • Chapter
  • First Online:
The Burden of Adult ADHD in Comorbid Psychiatric and Neurological Disorders
  • 1514 Accesses

Abstract

Among the Trauma- and Stressor-Related Disorders classified in DSM-5, Post-Traumatic Stress Disorder (PTSD) is one of the most frequently reported in people with ADHD and vice versa. As their clinical presentation overlaps for some features, it is very challenging for the clinician to recognize ADHD in individuals suffering from PTSD. PTSD is not so uncommon. In fact, there is evidence indicating a higher likelihood for developing a PTSD after some traumatic life events such as chronic illnesses, relationship problems, and unemployment in respect to after severe traumas such as accidents, physical and sexual assaults, and robbery.

ADHD is a disorder causing great impairment to people affected throughout lifetime, as they experience occupational and relationship problems as well physical accidents/trauma at higher frequency than in general population. Moreover, ADHD symptoms have been found associated with greater sexual victimization during adolescence, and linked with sexual victimization through engagement in risky sexual behavior. Therefore, greater vulnerability to the PTSD onset is expected.

From a neuropsychological point of view, individuals with PTSD suffer from impairment in attentional and memory cognitive domains, but deficits in attentional control and poor response inhibition can also predate the trauma exposure. Studies performed on youth with ADHD have shown a relationship between hyperarousal symptoms of PTSD and inattentive symptoms of ADHD, but no association with hyperactive/impulsive symptoms. However, results from studies on adults with both ADHD and PTSD were slightly different from those found in children and adolescents.

The 50% of people with PTSD do not respond to the main treatment, and this may be due to the presence of comorbid conditions. The vast majority of PTSD interventions are addressed to the re-experiencing and avoidance symptoms, with an absence of interventions focused on the neurocognitive deficits.

There is a paucity of studies investigating the effect of ADHD medication on PTSD symptomatology, but evidence up to date shows that methylphenidate improves not only PTSD symptoms but also depressive and post-concussive symptoms in individuals with PTSD, TBI, or both, and exerts a beneficial effect on cognition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.

    Google Scholar 

  2. American Psychiatric Association [APA]. DSM-5. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: Author; 2013.

    Book  Google Scholar 

  3. Kessler RC, Wang PS. The descriptive epidemiology of commonly occurring mental disorders in the United States. Annu Rev Public Health. 2008;29:115–29. https://doi.org/10.1146/annurev.publhealth.29.020907.090847.

    Article  PubMed  Google Scholar 

  4. Kessler RC, Adler LA, Gruber MJ, Sarawate CA, Spencer T, Van Brunt DL. Validity of the World health organization adult ADHD self-report scale (ASRS) Screener in a representative sample of health plan members. Int J Methods Psychiatr Res. 2007;16(2):52–65. https://doi.org/10.1002/mpr.208.

  5. Chapman JC, Diaz-Arrastia R. Military traumatic brain injury: a review. Alzheimers Dement. 2014;10:S97–S104. https://doi.org/10.1016/j.jalz.2014.04.012.

  6. Blakeley K, Jansen DJ. Post-Traumatic stress disorder and other mental health problems in the military: Oversight Issues for Congress. Washington, DC: Congressional Research Service. 2013.

    Google Scholar 

  7. Pagotto LF, Mendlowicz MV, Coutinho ES, Figueira I, Luz MP, Araujo AX. The impact of posttraumatic symptoms and comorbid mental disorders on the health-related quality of life in treatment-seeking PTSD patients. Compr. Psychiatry. 2015;58:68–73. https://doi.org/10.1016/j.comppsych.2015.01.002.

  8. Brattberg G. PTSD and ADHD: underlying factors in many cases of burnout. Stress Health. 2006;22:305–13.

    Article  Google Scholar 

  9. Perkonigg A, Pfister H, Stein MB, Hofler M, Lieb R, Maercker A, Wittchen HU. Longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults. Am J Psychiatry. 2005;162(7):1320–7.

    Article  PubMed  Google Scholar 

  10. Mol SS, Arntz A, Metsemakers JF, Dinant GJ, Vilters-van Montfort PA, Knottnerus JA. Symptoms of post-traumatic stress disorder after nontraumatic events: evidence from an open population study. Br J Psychiatry. 2005;186:494–9.

    Article  PubMed  Google Scholar 

  11. Deykin EY, Keane TM, Kaloupek D, Fincke G, Rothendler J, Siegfried M, Creamer K. Posttraumatic stress disorder and the use of health services. Psychosom Med. 2001;63(5):835–41.

    Article  CAS  PubMed  Google Scholar 

  12. Kimberling R, Calhoun KS. Somatic symptoms, social support and treatment seeking among sexual assault victims. J Consult Clin Psychol. 1994;62:333–40.

    Article  Google Scholar 

  13. Koss MP, Koss PG, Woodruff WJ. The deleterious effects of criminal victimization on women’s health care and medical utilization. Arch Intern Med. 1991;151:342–7.

    Article  CAS  PubMed  Google Scholar 

  14. Sareen J, Cox BJ, Clara I, Asmundson GJG. The relationship between anxiety disorders and physical disorders in the U.S. National Comorbidity Survey. Depress Anxiety. 2005;21(4):193–202.

    Article  PubMed  Google Scholar 

  15. Schnurr P, Green B. Trauma and health: physical health consequences of exposure to extreme stress. Washington, DC: American Psychological Association; 2004.

    Book  Google Scholar 

  16. Olatunji BO, Cisler JM, Tolin DF. Quality of life in the anxiety disorders: a meta-analytic review. Clin Psychol Rev. 2007;27(5):572–81.

    Article  PubMed  Google Scholar 

  17. Sayer NA, Carlson K, Schnurr P. Assessment of functioning and disability in individuals with PTSD. In: Benedek D, Wynn GH, editors. Clinical manual for the management of posttraumatic stress disorder. Arlington: American Psychiatric Association Publishing; 2011. p. 255–87.

    Google Scholar 

  18. Schnurr P, Lunney CA, Bovin MJ, Marx BP. Posttraumatic stress disorder and quality of life: extension of findings to veterans of the wars in Iraq and Afghanistan. Clin Psychol Rev. 2009;29(8):727–35.

    Article  PubMed  Google Scholar 

  19. Panagioti M, Gooding P, Tarrier N. Post-traumatic stress disorder and suicidal behavior: a narrative review. Clin Psychol Rev. 2009;29:471–82. https://doi.org/10.1016/j.cpr.2009.05.001.

    Article  PubMed  Google Scholar 

  20. Veterans Health Administration. The veterans health administration’s treatment of PTSD and traumatic brain injury among recent combat veterans. Congress of the United States Congressional Budget Office. 2012.

    Google Scholar 

  21. Brod M, Pohlman B, Lasser R, et al. Comparison of the burden of illness for adults with ADHD across seven countries: a qualitative study. Health Qual Life Outcomes. 2012;10:47.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Barkley RA, Cox D. A review of driving risks and impairments associated with attention-deficit/hyperactivity disorder and the effects of stimulant medication on driving performance. J Saf Res. 2007;38(1):113–28. [PubMed: 17303170].

    Article  Google Scholar 

  23. Antshel KM, Kaul P, Biederman J, Spencer TJ, Hier BO, Hendricks K, Faraone SV. Posttraumatic stress disorder in adult attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2013;74(03):E197–204.

    Article  PubMed  Google Scholar 

  24. Koenen KC, Moffitt TE, Poulton R, Martin J, Caspi A. Early childhood factors associated with the development of post-traumatic stress disorder: results form a longitudinal birth cohort. Psychol. Med. 2007;37:181–92. https://doi.org/10.1017/S0033291706009019.

  25. Glod CA, Teicher MH. Relationship between early abuse, posttraumatic stress disorder, and activity levels in prepubertal children. J Am Acad Child Adolesc Psychiatry. 1996;35:1384–93.

    Google Scholar 

  26. McLeer SV, Callaghan M, Henry D, Wallen J. Psychiatric disorders in sexually abused children. J Am Acad Child Adolesc Psychiatry. 1994;33:313–9.

    Google Scholar 

  27. Merry SN, Andrews LK. Psychiatric status of sexually abused children 12 months after disclosure of abuse. J Am Acad Child Adolesc Psychiatry. 1994;33:939–44.

    Google Scholar 

  28. Adler LA, Kunz M, Chua HC, Rotrosen J, Resnick SG. Attention deficit/hyperactivity disorder in adult patients with posttraumatic stress disorder (PTSD): Is ADHD a vulnerability factor? J. Atten. Disord. 2004;8:11–16. https://doi.org/10.1177/108705470400800102.

  29. Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet. 2005;366(9481):237–48.

    Google Scholar 

  30. Lee SS, Falk AE, Aguirre VP. Association of comorbid anxiety with social functioning in school-age children with and without attention-deficit/hyperactivity disorder (ADHD). Psychiatry Res. 2012;197(1–2):90–6.

    Article  PubMed  Google Scholar 

  31. White JW, Buehler C. Adolescent sexual victimization, ADHD symptoms, and risky sexual behavior. J Fam Violence. 2012;27(2):123–32. https://doi.org/10.1007/s10896-012-9411-y.

    Article  Google Scholar 

  32. Casey P. Adjustment disorder: epidemiology, diagnosis and treatment. CNS Drugs. 2009;23(11):927–38. https://doi.org/10.2165/11311000-000000000-00000.

    Article  PubMed  Google Scholar 

  33. Yaseen YA. Adjustment disorder: prevalence, sociodemographic risk factors, and its subtypes in outpatient psychiatric clinic. Asian J Psychiatr. 2017;28:82–5. https://doi.org/10.1016/j.ajp.2017.03.012. Epub 2017 Mar 16.

    Article  PubMed  Google Scholar 

  34. Arnsten AFT, Raskind MA, Taylor FB, Connor DF. The effects of stress exposure on prefrontal cortex: translating basic research into successful treatments for post-traumatic stress disorder. Neurobiol Stress. 2015;1:89–99. https://doi.org/10.1016/j.ynstr.2014.10.002.

    Article  PubMed  Google Scholar 

  35. Beers SR, Bellis MD. Outcomes of child abuse. Neurosurg Clin N Am. 2002;13(2):235–41.

    Google Scholar 

  36. Gilbertson MW, Gurvits TV, Lasko NB, Orr SP, Pitman RK. Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder. J Trauma Stress. 2001;14(2):413–32.

    Article  CAS  PubMed  Google Scholar 

  37. Golier JA, Yehuda R, Lupien SJ, Harvey PD, Grossman R, Elkin A. Memory performance in holocaust survivors with posttraumatic stress disorder. Am J Psychiatr. 2002;159(10):1682–8.

    Article  PubMed  Google Scholar 

  38. Jenkins MA, Langlais PJ, Delis D, Cohen RA. Attentional dysfunction associated with posttraumatic stress disorder among rape survivors. The Clinical Neuropsychologist. 2000;14:7–12. [PubMed: 10855055].

    Google Scholar 

  39. Vasterling JJ, Brailey K, Duke LM, Constans JI, Allain AN, Sutker PB. Attention, learning, and memory performances and intellectual resources in Vietnam veterans: PTSD and no disorder comparisons. Neuropsychology. 2002;16:5–14. [PubMed: 11853357].

    Google Scholar 

  40. Yehuda R, Keefe RSE, Harvey PD, Levengood RA, Gerber DK, Geni J, et al. Learning and memory in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 1995;152:137–9.

    Google Scholar 

  41. Bremner J. Does stress damage the brain? Biol Psychiatry. 1999;45(7):797–805.

    Article  CAS  PubMed  Google Scholar 

  42. Buckley TC, Blanchard EB, Neill WT. Information processing and PTSD: a review of the empirical literature. Clin Psychol Rev. 2000;20(8):1041–65.

    Article  CAS  PubMed  Google Scholar 

  43. Aupperle RL, Melrose AJ, Stein MB, Paulus MP. Executive function and PTSD: disengaging from trauma. Neuropharmacology. 2012;62(2):686–94.

    Article  CAS  PubMed  Google Scholar 

  44. Parslow RA, Jorm AF. Pretrauma and posttrauma neurocognitive functioning and PTSD symptoms in a community sample of young adults. Am J Psychiatry. 2007;164:509–15.

    Article  PubMed  Google Scholar 

  45. Ford JD, Racusin R, Ellis CG, Daviss WB, Reiser J, Fleischer A, et al. Child maltreatment, other trauma exposure, and posttraumatic symptomatology among children with oppositional defiant and attention deficit hyperactivity disorders. Child Maltreat. 2000;5:205–17. https://doi.org/10.1177/1077559500005003001.

  46. Husain SA, Allwood MA, Bell DJ. The relationship between PTSD symptoms and attention problems in children exposed to the bosnian war. J Emot Behav Disord. 2008;16:52–62. https://doi.org/10.1177/1063426607310847.

  47. Hanson JA, Haub MD, Walker JJ, Johnston DT, Goff BSN, Dretsch MN. Attention deficit hyperactivity disorder subtypes and their relation to cognitive functioning, mood states, and combat stress symptomatology in deploying U.S. soldiers. Military Medicine. 2012;17:655–62.

    Google Scholar 

  48. Harrington KM, Miller MW, Wolf EJ, Reardon AF, Ryabchenko KA, Ofrat S. Attention-deficit/hyperactivity disorder comorbidity in a sample of veterans with posttraumatic stress disorder. Compr. Psychiatry. 2012;53:679–90. https://doi.org/10.1016/j.comppsych.2011.12.001.

  49. Adams Z, Adams T, Stauffacher K, Mandel H, Wang Z. The effects of inattentiveness and hyperactivity on posttraumatic stress symptoms: does a diagnosis of posttraumatic stress disorder matter? J Atten Disord. 2015. https://doi.org/10.1177/1087054715580846. [published online ahead of print, 2015].

  50. Vasterling JJ, Brailey K, Constans JI, Sutker PB. Attention and memory dysfunction in posttraumatic stress disorder. Neuropsychology. 1998;12:125–33. https://doi.org/10.1037/0894-4105.12.1.125.

    Article  CAS  PubMed  Google Scholar 

  51. Samuelson KW, Metzler TJ, Rothlind J, Choucroun G, Neylan TC, Lenoci M, et al. Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse. Neuropsychology. 2006;20:716–26. https://doi.org/10.1037/0894-4105.20.6.716.

  52. Brandes D, Ben-Schachar G, Gilboa A, Bonne O, Freedman S, Shalev AY. PTSD symptoms and cognitive performance in recent trauma survivors. Psychiatry Res. 2002;110:231–8. [PubMed: 12127473].

    Google Scholar 

  53. Marmar CR, McCaslin SE, Metzler TJ, Best S, Weiss DS, Fagan J, et al. Predictors of posttraumatic stress in police and other first responders. Ann N Y Acad Sci. 2006;1071:1–18. [PubMed: 16891557].

    Google Scholar 

  54. Lagarde G, Doyon J, Brunet A. Memory and executive dysfunctions associated with acute posttraumatic stress disorder. Psychiatry Res. 2010;177:144–9. [PubMed: 20381880].

    Google Scholar 

  55. Neylan TC, Lenoci M, Rothlind J, Metzler TJ, Schuff N, Du A-T, Marmar CR. Attention, learning, and memory in posttraumatic stress disorder. J Trauma Stress. 2004;17(1):41–6. 10.1023/B:JOTS.0000014675.75686.ee. [PubMed: 15027792].

    Google Scholar 

  56. Leskin LP, White PM. Attentional networks reveal executive function deficits in posttraumatic stress disorder. Neuropsychology. 2007;21:275–84. [PubMed: 17484590].

    Google Scholar 

  57. Samuelson KW, Neylan TC, Metzler TJ, Lenoci M, Rothlind J, Henn-Haase C, et al. Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse. Neuropsychology. 2006a;20:716–26. [PubMed: 17100516].

    Google Scholar 

  58. McFarlane AC, Weber DL, Clark CR. Abnormal stimulus processing in posttraumatic stress disorder. Biol Psychiatry. 1993;34:311–20. [PubMed: 8399831].

    Google Scholar 

  59. Wu J, Ge Y, Shi Z, Duan X, Wang L, Sun X, et al. Response inhibition in adolescent earthquake survivors with and without posttraumatic stress disorder: A combined behavioral and ERP study. Neuroscience Letters. 2010.

    Google Scholar 

  60. Shucard JL, McCabe DC, Szymanski H. An event-related potential study of attention deficits in posttraumatic stress disorder during auditory and visual Go/NoGo continuous performance tasks. Biol Psychol. 2008;79:223–33. [PubMed: 18590795].

    Google Scholar 

  61. Falconer E, Bryant R, Felmingham KL, Kemp AH, Gordon E, Peduto A, et al. The neural networks of inhibitory control in posttraumatic stress disorder. Journal of Psychiatry & Neuroscience. 2008;33:413–22. [PubMed: 18787658].

    Google Scholar 

  62. Koso, M. and Hansen, S. Executive function and memory in posttraumatic stress disorder: A Study of Bosnian War Veterans. European Psychiatry. 2006;21:167–73.

    Google Scholar 

  63. Stroop J. Studies of interference in serial verbal reactions. J Exp Psychol. 1935;18:643–66.

    Google Scholar 

  64. Delis D, Kaplan E, Kramer J. Delis-Kaplan executive function system (D-KEFS): Examiner’s Manual. The Psychological Corporation; San Antonio,TX: 2001.

    Google Scholar 

  65. Lindauer RJ, Olff M, van Meijel EP, Carlier IV, Gersons BP. Cortisol, learning, memory, and attention in relation to smaller hippocampal volume in police officers with posttraumatic stress disorder. Biol Psychiatry. 2006;59:171–77. [PubMed: 16154543].

    Google Scholar 

  66. Ford JD, Connor DF. ADHD and posttraumatic stress disorder. Current Attention Disorders Reports. 2009;1(2):60–6. https://doi.org/10.1007/s12618-009-0009-0.

  67. Davis M. The role of the amygdala in conditioned fear. In: Aggleton J, editor. The amygdala: neurobiological aspects of emotion, memory and mental dysfunction. New York: Wiley-Liss; 1992. p. 255–5.

    Google Scholar 

  68. Davis M, Falls WA, Campeau S, Kim M. Fear-potentiated startle: a neural and pharmacological analysis. Behav Brain Res. 1993;58(1–2):175–98.

    Article  CAS  PubMed  Google Scholar 

  69. Glover EM, Jovanovic T, Mercer KB, Kerley K, Bradley B, Ressler KJ, Norrholm SD. Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biol Psychiatry. 2012;72(1):19–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Norrholm SD, Glover EM, Stevens JS, et al. Fear load: The psychophysiological over-expression of fear as an intermediate phenotype associated with trauma reactions. Int J Psychophysiol. 2015;98(2 Pt 2):270–5. https://doi.org/10.1016/j.ijpsycho.2014.11.005.

  71. Waite R. Women and attention deficit disorders: a great burden overlooked. J Am Acad Nurse Pract. 2007;19(3):116–25.

    Article  PubMed  Google Scholar 

  72. Patton JH, Stanford MS, Barratt ES. Factor structure of the barratt impulsiveness scale. J Clin Psychol. 1995;51(6):768–74. [PubMed: 8778124].

    Google Scholar 

  73. Barkley RA. Barkley deficits in executive functioning scale (BDEFS). New York: Guilford Press; 2011.

    Google Scholar 

  74. Ustun B, Adler LA, Rudin C, et al. The world health organization adult attention-deficit/hyperactivity disorder self-report screening scale for DSM-5. JAMA Psychiatry. 2017;74(5):520–7. https://doi.org/10.1001/jamapsychiatry.2017.0298.

  75. Barkley RA. Barkley adult ADHD rating scale-IV (BAARS-IV). New York, NY, US: Guilford Press. 2011.

    Google Scholar 

  76. Kooij JJS. Diagnostic interview for ADHD in adults 2.0 (DIVA 2.0). Adult ADHD. Diagnostic assessment and treatment. Amsterdam: Pearson Assessment and Information BV; 2010.

    Google Scholar 

  77. Conners CK. Conners continuous performance test 3rd edition (CPT3). North Tonawanda, NY: Multi-Health Systems. 2014.

    Google Scholar 

  78. American Psychological Association. Guideline development panel for the treatment of posttraumatic stress disorder in adults. Adopted as APA Policy February 24, 2017. http://www.apa.org/ptsd-guideline/ptsd.pdf. Accessed 22 Aug 2018.

  79. Rotaru TȘ, Rusu A. A meta-analysis for the efficacy of hypnotherapy in alleviating PTSD symptoms. Int J Clin Exp Hypn. 2016;64(1):116–36. https://doi.org/10.1080/00207144.2015.1099406.

    Article  PubMed  Google Scholar 

  80. Eads B, Wark DM. Alert hypnotic inductions: use in treating combat post-traumatic stress disorder. Am J Clin Hypn. 2015;58(2):159–70. https://doi.org/10.1080/00029157.2014.979276.

    Article  PubMed  Google Scholar 

  81. Katzman MA, Bleau P, Blier P, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014;14(Suppl 1):S1. https://doi.org/10.1186/1471-244X-14-S1-S1.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Davidson J, Connor K, Hertzberg M, Weisler R, Wilson W, Payne V. Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study. J Clin Psychopharmacol. 2005;25:166–9.

    Article  CAS  PubMed  Google Scholar 

  83. Martenyi F, Brown E, Zhang H, Koke S, Prakash A. Fluoxetine v. placebo in prevention of relapse in post-traumatic stress disorder. Br J Psychiatry. 2002;181:315–20.

    Article  PubMed  Google Scholar 

  84. Davidson J, Pearlstein T, Londborg P, Brady K, Rothbaum B, Bell J, Maddock R, Hegel M, Farfel G. Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study. Am J Psychiatry. 2001;158:1974–81.

    Article  CAS  PubMed  Google Scholar 

  85. Kim Y, Asukai N, Konishi T, Kato H, Hirotsune H, Maeda M, Inoue H, Narita H, Iwasaki M. Clinical evaluation of paroxetine in post-traumatic stress disorder (PTSD): 52-week, non-comparative open-label study for clinical use experience. Psychiatry Clin Neurosci. 2008;62:646–52.

    Article  CAS  PubMed  Google Scholar 

  86. Londborg P, Hegel M, Goldstein S, Goldstein D, Himmelhoch J, Maddock R, Patterson W, Rausch J, Farfel G. Sertraline treatment of posttraumatic stress disorder: results of 24 weeks of open-label continuation treatment. J Clin Psychiatry. 2001;62:325–31.

    Article  CAS  PubMed  Google Scholar 

  87. Byers MG, Allison KM, Wendel CS, Lee JK. Prazosin versus quetiapine for nighttime posttraumatic stress disorder symptoms in veterans: an assessment of long-term comparative effectiveness and safety. J Clin Psychopharmacol. 2010;30:225–9.

    Article  PubMed  Google Scholar 

  88. Raskind M, Peskind E, Kanter E, Petrie E, Radant A, Thompson C, Dobie D, Hoff D, Rein R, Straits-Troster K, et al. Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am J Psychiatry. 2003;160:371–3.

    Article  PubMed  Google Scholar 

  89. Peskind E, Bonner L, Hoff D, Raskind M. Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder. J Geriatr Psychiatry Neurol. 2003;16:165–71.

    Article  PubMed  Google Scholar 

  90. Taylor F, Raskind M. The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder. J Clin Psychopharmacol. 2002;22:82–5.

    Article  CAS  PubMed  Google Scholar 

  91. Raskind MA, Peskind ER, Hoff DJ, Hart KL, Holmes HA, Warren D, Shofer J, O’Connell J, Taylor F, Gross C, et al. A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007;61:928–34.

    Article  CAS  PubMed  Google Scholar 

  92. Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA. Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry. 2008;63:629–32.

    Article  CAS  PubMed  Google Scholar 

  93. Lubin G, Weizman A, Shmushkevitz M, Valevski A. Short-term treatment of post-traumatic stress disorder with naltrexone: an open-label preliminary study. Hum Psychopharmacol. 2002;17:181–5.

    Article  CAS  PubMed  Google Scholar 

  94. Bohus MJ, Landwehrmeyer GB, Stiglmayr CE, Limberger MF, Bohme R, Schmahl CG. Naltrexone in the treatment of dissociative symptoms in patients with borderline personality disorder: an open-label trial. J Clin Psychiatry. 1999;60:598–603.

    Article  CAS  PubMed  Google Scholar 

  95. Glover H. A preliminary trial of nalmefene for the treatment of emotional numbing in combat veterans with post-traumatic stress disorder. Isr J Psychiatry Relat Sci. 1993;30:255–63.

    CAS  PubMed  Google Scholar 

  96. Bills LJ, Kreisler K. Treatment of flashbacks with naltrexone. Am J Psychiatry. 1993;150:1430.

    CAS  PubMed  Google Scholar 

  97. Pivac N, Kozaric-Kovacic D, Muck-Seler D. Olanzapine versus fluphenazine in an open trial in patients with psychotic combat-related posttraumatic stress disorder. Psychopharmacology (Berl). 2004;175:451–6.

    CAS  Google Scholar 

  98. Boggio PS, Rocha M, Oliveira MO, Fecteau S, Cohen RB, Campanha C, Ferreira-Santos E, Meleiro A, Corchs F, Zaghi S, et al. Noninvasive brain stimulation with high-frequency and low-intensity repetitive transcranial magnetic stimulation treatment for posttraumatic stress disorder. J Clin Psychiatry. 2010;71:992–9.

    Article  PubMed  Google Scholar 

  99. Watts BV, Landon B, Groft A, Young-Xu Y. A sham controlled study of repetitive transcranial magnetic stimulation for posttraumatic stress disorder. Brain Stimul. 2012;5:38–43.

    Article  PubMed  Google Scholar 

  100. Osuch EA, Benson BE, Luckenbaugh DA, Geraci M, Post RM, McCann U. Repetitive TMS combined with exposure therapy for PTSD: a preliminary study. J Anxiety Disord. 2009;23:54–9.

    Article  PubMed  Google Scholar 

  101. Margoob MA, Ali Z, Andrade C. Efficacy of ECT in chronic, severe, antidepressant- and CBT-refractory PTSD: an open, prospective study. Brain Stimul. 2010;3:28–35.

    Article  PubMed  Google Scholar 

  102. Watts BV. Electroconvulsive therapy for comorbid major depressive disorder and posttraumatic stress disorder. J ECT. 2007;23:93–5.

    Article  PubMed  Google Scholar 

  103. Abraham AD, Cunningham CL, Lattal KM. Methylphenidate enhances extinction of contextual fear. Learn Mem. 2012;19:67–72. https://doi.org/10.1101/lm.024752.111. Downloaded from learnmem.cshlp.org on August 23, 2018—Published by Cold Spring Harbor Laboratory Press.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. McAllister TW, Zafonte R, Jain S, Flashman LA, George MS, Grant GA, et al. Randomized placebo-controlled trial of methylphenidate or galantamine for persistent emotional and cognitive symptoms associated with PTSD and/or traumatic brain injury. Neuropsychopharmacology. 2016;41:1191–8. https://doi.org/10.1038/npp.2015.282.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pallanti, S., Salerno, L. (2020). Adult ADHD in Trauma- and Stressor-Related Disorders. In: The Burden of Adult ADHD in Comorbid Psychiatric and Neurological Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-39051-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-39051-8_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-39050-1

  • Online ISBN: 978-3-030-39051-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics