Abstract
Total body irradiation (TBI) is used as part of the conditioning regimen for allogeneic stem cell transplants since the 1970s. Current TBI uses 2D radiation planning to treat the whole body with lung blocks. Currently, lung is the only normal organ that is spared in full dose TBI, but we only have an estimate of the lung dose due to 2D planning. Recent papers suggest that TBI toxicity could be lowered by sparing normal organs the TBI dose and providing specific guidelines for lung dose. Intensity-modulated radiation treatment (IMRT) is a conformal, more targeted form of radiation that treats patients with 3D planning. With IMRT TBI, we can selectively prescribe full dose TBI while sparing critical organs such as lungs, kidney, and lens. Moreover, IMRT TBI allows more accurate dosimetric calculations of dose to normal structures. With modern technology and widespread use of IMRT already, we expect IMRT TBI to become the new standard for TBI.
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Dandapani, S.V., Wong, J.Y.C. (2020). Modern Total Body Irradiation (TBI): Intensity-Modulated Radiation Treatment (IMRT). In: Wong, J., Hui, S. (eds) Total Marrow Irradiation. Springer, Cham. https://doi.org/10.1007/978-3-030-38692-4_13
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DOI: https://doi.org/10.1007/978-3-030-38692-4_13
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