Skip to main content

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

  • 596 Accesses

Abstract

The modern personalized medicine approaches in oncology deal with a huge and barely manageable number of patient-specific variables, from genetic data to simple blood tests, trying to ensure a fully individualized and tailored therapy.

In this context, the recent research trends towards imaging biomarkers, quantitative imaging analysis and radiomics applications have gained an ever-increasing interest, leading to the proposal of imaging-based predictors for clinical decision support systems (DSS).

The application of advanced machine learning solutions to manage always larger databases of patient imaging-derived variables is becoming increasingly necessary and opens new frontiers in the field of clinical outcome prediction.

The different types of predictive modelling techniques, together with their strengths and pitfalls, are highlighted in this chapter which offers a brief overview about the state of the art as well as on the future developments of this fascinating topic.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aerts HJWL, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Cavalho S, Hoebers F (2014) Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun 5(4006):1–8

    Google Scholar 

  • Amthauer H, Denecke T, Rau B, Hildebrandt B, Hünerbein M, Ruf J, Wust P (2004) Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: correlation with endorectal ultrasound and histopathology. Eur J Nucl Med Mol Imaging 31(6):811–819

    Article  PubMed  Google Scholar 

  • Bakke KM, Hole KH, Dueland S, Grøholt KK, Flatmark K, Ree AH, Redalen KR (2017) Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival. Acta Oncol 56(6):813–818

    Article  PubMed  Google Scholar 

  • Beets-Tan RG, Beets GL (2014) MRI for assessing and predicting response to neoadjuvant treatment in rectal cancer. Nat Rev Gastroenterol Hepatol 11(8):480–488

    Article  CAS  PubMed  Google Scholar 

  • Beppu N, Kato T, Noda M, Yanagi H, Tomita N, Kamikonya N, Hirota S (2015) Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. Mol Clin Oncol 3(5):1129–1134

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bhooshan N, Giger M, Edwards D, Yuan Y, Jansen S, Li H, Newstead G (2011) Computerized three-class classification of MRI-based prognostic markers for breast cancer. Phys Med Biol 56(18):5995

    Article  PubMed  PubMed Central  Google Scholar 

  • Bradley AP (1997) The use of the area under the ROC curve in the evaluation of machine learning algorithms. Pattern Recogn 30(7):1145–1159

    Article  Google Scholar 

  • Castellano G, Bonilha L, Li LM, Cendes F (2004) Texture analysis of medical images. Clin Radiol 59(12):1061–1069

    Article  CAS  PubMed  Google Scholar 

  • Collins GS, Reitsma JB, Altman DG, Moons KG (2015) Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMC Med 13(1):1

    Article  PubMed  PubMed Central  Google Scholar 

  • Damiani A, Vallati M, Gatta R, Dinapoli N, Jochems A, Deist T, Valentini V (2015) Distributed learning to protect privacy in multi-centric clinical studies. In: Conference on artificial intelligence in medicine in Europe. Springer, Cham, pp 65–75

    Google Scholar 

  • Dang M, Lysack JT, Wu T, Matthews TW, Chandarana SP, Brockton NT, Dort JC (2015) MRI texture analysis predicts p53 status in head and neck squamous cell carcinoma. Am J Neuroradiol 36(1):166–170

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Davnall F, Yip CS, Ljungqvist G, Selmi M, Ng F, Sanghera B, Goh V (2012) Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice? Insights Imaging 3(6):573–589

    Article  PubMed  PubMed Central  Google Scholar 

  • De Cecco CN, Ganeshan B, Ciolina M, Rengo M, Meinel FG, Musio D, Laghi A (2015) Texture analysis as imaging biomarker of tumoral response to neoadjuvant chemoradiotherapy in rectal cancer patients studied with 3-T magnetic resonance. Investig Radiol 50(4):239–245

    Article  CAS  Google Scholar 

  • Deasy JO, Blanco AI, Clark VH (2003) CERR: a computational environment for radiotherapy research. Med Phys 30(5):979–985

    Article  PubMed  Google Scholar 

  • Denecke T, Rau B, Hoffmann KT, Hildebrandt B, Ruf J, Gutberlet M, Amthauer H (2005) Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging? Eur Radiol 15(8):1658–1666

    Article  CAS  PubMed  Google Scholar 

  • Dinapoli N, Alitto AR, Vallati M, Gatta R, Autorino R, Boldrini L, Valentini V (2015) Moddicom: a complete and easily accessible library for prognostic evaluations relying on image features. In: Engineering in Medicine and Biology Society (EMBC), 2015 37th annual international conference of the IEEE. IEEE, pp 771–774

    Google Scholar 

  • Dinapoli N, Casà C, Barbaro B, Chiloiro GV, Damiani A, Matteo MD, Masciocchi C, Valentini V (2016) Radiomics for rectal cancer. Transl Cancer Res 5(4):424–431

    Article  Google Scholar 

  • Doi H, Beppu N, Kato T, Noda M, Yanagi H, Tomita N, Hirota S (2015) Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. Mol Clin Oncol 3(5):1129–1134

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Elmi A, Hedgire SS, Covarrubias D, Abtahi SM, Hahn PF, Harisinghani M (2013) Apparent diffusion coefficient as a non-invasive predictor of treatment response and recurrence in locally advanced rectal cancer. Clin Radiol 68(10):e524–e531

    Article  CAS  PubMed  Google Scholar 

  • Everaert H, Hoorens A, Vanhove C, Sermeus A, Ceulemans G, Engels B, De Ridder M (2011) Prediction of response to neoadjuvant radiotherapy in patients with locally advanced rectal cancer by means of sequential 18FDG-PET. Int J Radiat Oncol Biol Phys 80(1):91–96

    Article  PubMed  Google Scholar 

  • Fakoor R, Ladhak F, Nazi A, Huber M (2013) Using deep learning to enhance cancer diagnosis and classification. In: Proceedings of the international conference on machine learning

    Google Scholar 

  • Fang YHD, Lin CY, Shih MJ, Wang HM, Ho TY, Liao CT, Yen TC (2014) Development and evaluation of an open-source software package “CGITA” for quantifying tumor heterogeneity with molecular images. Biomed Res Int 2014:1

    Google Scholar 

  • Ferrari M, Travaini LL, Ciardo D, Garibaldi C, Gilardi L, Glynne-Jones R, Leonardi MC (2017) Interim 18FDG PET/CT during radiochemotherapy in the management of pelvic malignancies: a systematic review. Crit Rev Oncol Hematol 113:28–42

    Article  PubMed  Google Scholar 

  • Gatenby RA, Grove O, Gillies RJ (2013) Quantitative imaging in cancer evolution and ecology. Radiology 269(1):8–14

    Article  PubMed  PubMed Central  Google Scholar 

  • Genovesi D, Filippone A, Cefaro GA, Trignani M, Vinciguerra A, Augurio A, Liberatore E (2013) Diffusion-weighted magnetic resonance for prediction of response after neoadjuvant chemoradiation therapy for locally advanced rectal cancer: preliminary results of a monoinstitutional prospective study. Eur J Surg Oncol (EJSO) 39(10):1071–1078

    Article  CAS  Google Scholar 

  • Goldberg N, Kundel Y, Purim O, Bernstine H, Gordon N, Morgenstern S, Brenner B (2012) Early prediction of histopathological response of rectal tumors after one week of preoperative radiochemotherapy using 18 F-FDG PET-CT imaging. A prospective clinical study. Radiat Oncol 7(1):124

    Article  PubMed  PubMed Central  Google Scholar 

  • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674

    Article  CAS  PubMed  Google Scholar 

  • Hatt M, Van Stiphout R, Le Pogam A, Lammering G, Visvikis D, Lambin P (2013) Early prediction of pathological response in locally advanced rectal cancer based on sequential 18F-FDG PET. Acta Oncol 52(3):619–626

    Article  CAS  PubMed  Google Scholar 

  • How P, Evans J, Moran B, Swift I, Brown G (2012) Preoperative MRI sphincter morphology and anal manometry: can they be markers of functional outcome following anterior resection for rectal cancer? Color Dis 14(6):e339

    Article  CAS  Google Scholar 

  • Hsu CY, Wang CW, Kuo CC, Chen YH, Lan KH, Cheng AL, Kuo SH (2017) Tumor compactness improves the preoperative volumetry-based prediction of the pathological complete response of rectal cancer after preoperative concurrent chemoradiotherapy. Oncotarget 8(5):7921

    Article  PubMed  Google Scholar 

  • Hu J, Wu W, Zhu B, Wang H, Liu R, Zhang X, Tian C (2016) Cerebral glioma grading using Bayesian network with features extracted from multiple modalities of magnetic resonance imaging. PLoS One 11(4):e0153369

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Intven M, Monninkhof EM, Reerink O, Philippens ME (2015a) Combined T2w volumetry, DW-MRI and DCE-MRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer. Acta Oncol 54(10):1729–1736

    Article  CAS  PubMed  Google Scholar 

  • Intven M, Reerink O, Philippens ME (2015b) Dynamic contrast enhanced MR imaging for rectal cancer response assessment after neo-adjuvant chemoradiation. J Magn Reson Imaging 41(6):1646–1653

    Article  PubMed  Google Scholar 

  • Ishibe A, Ota M, Watanabe J, Suwa Y, Suzuki S, Kanazawa A, Endo I (2016) Prediction of lateral pelvic lymph-node metastasis in low rectal cancer by magnetic resonance imaging. World J Surg 40(4):995–1001

    Article  PubMed  Google Scholar 

  • Jacobs L, Intven M, Van Lelyveld N, Philippens M, Burbach M, Seldenrijk K, Reerink O (2016) Diffusion-weighted MRI for early prediction of treatment response on preoperative chemoradiotherapy for patients with locally advanced rectal cancer: a feasibility study. Ann Surg 263(3):522–528

    Article  PubMed  Google Scholar 

  • Janssen MH, Öllers MC, Riedl RG, van den Bogaard J, Buijsen J, van Stiphout RG, Lammering G (2010) Accurate prediction of pathological rectal tumor response after two weeks of preoperative radiochemotherapy using 18 F-fluorodeoxyglucose-positron emission tomography-computed tomography imaging. Int J Radiat Oncol Biol Phys 77(2):392–399

    Article  PubMed  Google Scholar 

  • Jochems A, Deist TM, Van Soest J, Eble M, Bulens P, Coucke P, Dekker A (2016) Distributed learning: developing a predictive model based on data from multiple hospitals without data leaving the hospital—a real life proof of concept. Radiother Oncol 121(3):459–467

    Article  PubMed  Google Scholar 

  • Joye I, Deroose CM, Vandecaveye V, Haustermans K (2014) The role of diffusion-weighted MRI and 18 F-FDG PET/CT in the prediction of pathologic complete response after radiochemotherapy for rectal cancer: a systematic review. Radiother Oncol 113(2):158–165

    Article  PubMed  Google Scholar 

  • Joye I, Debucquoy A, Deroose CM, Vandecaveye V, Van Cutsem E, Wolthuis A, Haustermans K (2017) Quantitative imaging outperforms molecular markers when predicting response to chemoradiotherapy for rectal cancer. Radiother Oncol 124(1):104–109

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim JW, Kim HC, Park JW, Park SC, Sohn DK, Choi HS, Kim SK (2013) Predictive value of 18FDG PET-CT for tumour response in patients with locally advanced rectal cancer treated by preoperative chemoradiotherapy. Int J Color Dis 28(9):1217–1224

    Google Scholar 

  • Kim JG, Song KD, Kim SH, Kim HC, Huh JW (2016) Diagnostic performance of MRI for prediction of candidates for local excision of rectal cancer (ypT0-1N0) after neoadjuvant chemoradiation therapy. J Magn Reson Imaging 44(2):471–477

    Article  PubMed  Google Scholar 

  • Kim HG, Han SH, Choi HJ (2017) Discriminative restricted Boltzmann machine for emergency detection on healthcare robot. In: 2017 IEEE international conference on Big data and smart computing (BigComp). IEEE, pp 407–409

    Google Scholar 

  • Konski A, Li T, Sigurdson E, Cohen SJ, Small W, Spies S, Meropol NJ (2009) Use of molecular imaging to predict clinical outcome in patients with rectal cancer after preoperative chemotherapy and radiation. Int J Radiat Oncol Biol Phys 74(1):55–59

    Article  CAS  PubMed  Google Scholar 

  • Kotsiantis SB, Zaharakis I, Pintelas P. 2007. Supervised machine learning: a review of classification techniques

    Google Scholar 

  • Kourou K, Exarchos TP, Exarchos KP, Karamouzis MV, Fotiadis DI (2015) Machine learning applications in cancer prognosis and prediction. Comput Struct Biotechnol J 13:8–17

    Article  CAS  PubMed  Google Scholar 

  • Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Goldgof DB (2012) Radiomics: the process and the challenges. Magn Reson Imaging 30(9):1234–1248

    Article  PubMed  PubMed Central  Google Scholar 

  • Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P, Aerts HJ (2012) Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer 48(4):441–446

    Article  PubMed  PubMed Central  Google Scholar 

  • Lambin P, Roelofs E, Reymen B, Velazquez ER, Buijsen J, Zegers CM, Marshall MS (2013) Rapid learning health care in oncology’—an approach towards decision support systems enabling customised radiotherapy. Radiother Oncol 109(1):159–164

    Article  PubMed  Google Scholar 

  • Lambrecht M, Deroose C, Roels S, Vandecaveye V, Penninckx F, Sagaert X, Haustermans K (2010) The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancer. Acta Oncol 49(7):956–963

    Article  PubMed  Google Scholar 

  • Leccisotti L, Gambacorta MA, de Waure C, Stefanelli A, Barbaro B, Vecchio FM, Giordano A (2015) The predictive value of 18F-FDG PET/CT for assessing pathological response and survival in locally advanced rectal cancer after neoadjuvant radiochemotherapy. Eur J Nucl Med Mol Imaging 42(5):657–666

    Article  CAS  PubMed  Google Scholar 

  • Lee JH, Jang HS, Kim JG, Lee MA, Kim DY, Kim TH, Park HC (2014) Prediction of pathologic staging with magnetic resonance imaging after preoperative chemoradiotherapy in rectal cancer: pooled analysis of KROG 10-01 and 11-02. Radiother Oncol 113(1):18–23

    Article  PubMed  Google Scholar 

  • Lee G, Lee HY, Ko ES, Jeong WK, Lee G, Lee HY, Jeong WK (2017a) Radiomics and imaging genomics in precision medicine. Precision Future Med 1(1):10–31

    Article  CAS  Google Scholar 

  • Lee G, Lee HY, Park H, Schiebler ML, van Beek EJ, Ohno Y, Leung A (2017b) Radiomics and its emerging role in lung cancer research, imaging biomarkers and clinical management: state of the art. Eur J Radiol 86:297–307

    Article  PubMed  Google Scholar 

  • Li C, Lan X, Yuan H, Feng H, Xia X, Zhang Y (2014) 18F-FDG PET predicts pathological response to preoperative chemoradiotherapy in patients with primary rectal cancer: a meta-analysis. Ann Nucl Med 28(5):436–446

    Article  CAS  PubMed  Google Scholar 

  • Liu YI, Kamaya A, Desser TS, Rubin DL (2011) A bayesian network for differentiating benign from malignant thyroid nodules using sonographic and demographic features. Am J Roentgenol 196(5):W598–W605

    Article  Google Scholar 

  • Liu H, Cui Y, Shen W, Fan X, Cui L, Zhang C, Wang D (2016a) Pretreatment magnetic resonance imaging of regional lymph nodes with carcinoembryonic antigen in prediction of synchronous distant metastasis in patients with rectal cancer. Oncotarget 7(19):27199

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Wang R, Ding Y, Tu S, Liu Y, Qian Y, Peng J (2016b) A predictive nomogram improved diagnostic accuracy and interobserver agreement of perirectal lymph nodes metastases in rectal cancer. Oncotarget 7(12):14755

    Article  PubMed  PubMed Central  Google Scholar 

  • Lucas PJ, Van der Gaag LC, Abu-Hanna A (2004) Bayesian networks in biomedicine and health-care. Artif Intell Med 30(3):201–214

    Article  PubMed  Google Scholar 

  • Ma F, Chitta R, Zhou J, You Q, Sun T, Gao J (2017) Dipole: diagnosis prediction in healthcare via attention-based bidirectional recurrent neural networks. In: Proceedings of the 23rd ACM SIGKDD international conference on knowledge discovery and data mining. ACM, pp. 1903–1911

    Google Scholar 

  • Maclin PS, Dempsey J, Brooks J, Rand J (1991) Using neural networks to diagnose cancer. J Med Syst 15(1):11–19

    Article  CAS  PubMed  Google Scholar 

  • Martens MH, Subhani S, Heijnen LA, Lambregts DM, Buijsen J, Maas M, Rg B-T (2015) Can perfusion MRI predict response to preoperative treatment in rectal cancer? Radiother Oncol 114(2):218–223

    Article  PubMed  Google Scholar 

  • Meldolesi E, van Soest J, Alitto AR, Autorino R, Dinapoli N, Dekker A, Valentini V (2014) VATE: VAlidation of high TEchnology based on large database analysis by learning machine. Future Med 3(5):435–450

    Google Scholar 

  • Meng X, Huang Z, Wang R, Yu J (2014) Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer. Biosci Trends 8(1):11–23

    Article  CAS  PubMed  Google Scholar 

  • Moon SJ, Cho SH, Kim GC, Kim WH, Kim HJ, Shin KM, Kim SH (2016) Complementary value of pre-treatment apparent diffusion coefficient in rectal cancer for predicting tumor recurrence. Abdom Radiol 41(7):1237–1244

    Article  Google Scholar 

  • Moons KG, Kengne AP, Grobbee DE, Royston P, Vergouwe Y, Altman DG, Woodward M (2012) Risk prediction models: II. External validation, model updating, and impact assessment. In: Heart Heartjnl-2011, vol 98, p 691

    Google Scholar 

  • O’Connor JP, Rose CJ, Waterton JC, Carano RA, Parker GJ, Jackson A (2015) Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome. Clin Cancer Res 21(2):249–257

    Article  PubMed  CAS  Google Scholar 

  • Ogawa S, Hida JI, Ike H, Kinugasa T, Ota M, Shinto E, Watanabe T (2017) Prediction of lateral pelvic lymph node metastasis from lower rectal cancer using magnetic resonance imaging and risk factors for metastasis: Multicenter study of the Lymph Node Committee of the Japanese Society for cancer of the colon and rectum. Int J Colorectal Dis 32(10):1479–1487

    Article  PubMed  Google Scholar 

  • van Panhuis WG, Paul P, Emerson C, Grefenstette J, Wilder R, Herbst AJ, Burke DS (2014) A systematic review of barriers to data sharing in public health. BMC Public Health 14(1):1144

    Article  PubMed  PubMed Central  Google Scholar 

  • Pham TT, Liney GP, Wong K, Barton MB (2017a) Functional MRI for quantitative treatment response prediction in locally advanced rectal cancer. Br J Radiol 90(1072):20151078

    Article  PubMed  PubMed Central  Google Scholar 

  • Pham TT, Liney G, Wong K, Rai R, Lee M, Moses D, Barton MB (2017b) Study protocol: multi-parametric magnetic resonance imaging for therapeutic response prediction in rectal cancer. BMC Cancer 17(1):465

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Popescu MC, Sasu LM (2014) Feature extraction, feature selection and machine learning for image classification: a case study. In: 2014 international conference on Optimization of Electrical and Electronic Equipment (OPTIM). IEEE, pp 968–973

    Google Scholar 

  • Roelofs E, Dekker A, Meldolesi E, van Stiphout RG, Valentini V, Lambin P (2014) International data-sharing for radiotherapy research: an open-source based infrastructure for multicentric clinical data mining. Radiother Oncol 110(2):370–374

    Article  PubMed  Google Scholar 

  • Rosenblatt F (1958) The perceptron: a probabilistic model for information storage and organization in the brain. Psychol Rev 65(6):386

    Article  CAS  PubMed  Google Scholar 

  • Seierstad T, Hole KH, Grøholt KK, Dueland S, Ree AH, Flatmark K, Redalen KR (2015) MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer. Br J Radiol 88(1051):20150097

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shen D, Wu G, Suk HI (2017) Deep learning in medical image analysis. Annu Rev Biomed Eng 19:221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shin YR, Kim KA, Im S, Hwang SS, Kim K (2016) Prediction of KRAS mutation in rectal cancer using MRI. Anticancer Res 36(9):4799–4804

    Article  CAS  PubMed  Google Scholar 

  • Soest J, Meldolesi E, Stiphout R, Gatta R, Damiani A, Valentini V, Dekker A (2017) Prospective validation of pathologic complete response models in rectal cancer: transferability and reproducibility. Med Phys 44(9):4961–4967

    Article  PubMed  Google Scholar 

  • Steyerberg EW (2008) Clinical prediction models: a practical approach to development, validation, and updating. Springer Science & Business Media, Cham

    Google Scholar 

  • van Stiphout RG, Lammering G, Buijsen J, Janssen MH, Gambacorta MA, Slagmolen P, Postma EO (2011) Development and external validation of a predictive model for pathological complete response of rectal cancer patients including sequential PET-CT imaging. Radiother Oncol 98(1):126–133

    Article  PubMed  Google Scholar 

  • van Stiphout RG, Valentini V, Buijsen J, Lammering G, Meldolesi E, van Soest J, Lambin P (2014) Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: a multicentric prospective study with external validation. Radiother Oncol 113(2):215–222

    Article  PubMed  Google Scholar 

  • Suresh H, Hunt N, Johnson A, Celi LA, Szolovits P, Ghassemi M (2017) Clinical intervention prediction and understanding using deep networks. arXiv preprint arXiv:1705.08498

    Google Scholar 

  • Szczypiński PM, Strzelecki M, Materka A, Klepaczko A (2009) MaZda—a software package for image texture analysis. Comput Methods Prog Biomed 94(1):66–76

    Article  Google Scholar 

  • Tagliaferri L, Kovács G, Autorino R, Budrukkar A, Guinot JL, Hildebrand G, Rovirosa A (2016) ENT COBRA (Consortium for Brachytherapy Data Analysis): interdisciplinary standardized data collection system for head and neck patients treated with interventional radiotherapy (brachytherapy). J Contemp Brachyther 8(4):336

    Article  Google Scholar 

  • Thor M, Apte A, Deasy JO, Muren LP (2013) Statistical simulations to estimate motion-inclusive dose-volume histograms for prediction of rectal morbidity following radiotherapy. Acta Oncol 52(3):666–675

    Article  PubMed  Google Scholar 

  • Tsai C, Hague C, Xiong W, Raval M, Karimuddin A, Brown C, Phang PT (2017) Evaluation of endorectal ultrasound (ERUS) and MRI for prediction of circumferential resection margin (CRM) for rectal cancer. Am J Surg 213(5):936–942

    Article  PubMed  Google Scholar 

  • Valentini V, Van Stiphout RG, Lammering G, Gambacorta MA, Barba MC, Bebenek M, Gerard JP (2011) Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials. J Clin Oncol 29(23):3163–3172

    Article  PubMed  Google Scholar 

  • Valentini V, Dinapoli N, Damiani A (2013) The future of predictive models in radiation oncology: from extensive data mining to reliable modeling of the results. Future Oncol 9(3):311–313

    Article  CAS  PubMed  Google Scholar 

  • Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW (2013) Cancer genome landscapes. Science 339(6127):1546–1558

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wernick MN, Yang Y, Brankov JG, Yourganov G, Strother SC (2010) Machine learning in medical imaging. IEEE Signal Process Mag 27(4):25–38

    Article  PubMed  PubMed Central  Google Scholar 

  • Win T, Miles KA, Janes SM, Ganeshan B, Shastry M, Endozo R, Ell PJ (2013) Tumor heterogeneity and permeability as measured on the CT component of PET/CT predict survival in patients with non–small cell lung cancer. Clin Cancer Res 19(13):3591–3599

    Article  CAS  PubMed  Google Scholar 

  • Yan P, Suzuki K, Wang F, Shen D (2013) Machine learning in medical imaging. Mach Vis Appl 24:1327–1329

    Article  Google Scholar 

  • Zhang L, Fried DV, Fave XJ, Hunter LA, Yang J, Court LE (2015) IBEX: an open infrastructure software platform to facilitate collaborative work in radiomics. Med Phys 42(3):1341–1353

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Boldrini, L., Masciocchi, C., Leccisotti, L. (2020). Imaging-Based Prediction Models. In: Beets-Tan, R., Oyen, W., Valentini, V. (eds) Imaging and Interventional Radiology for Radiation Oncology. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-030-38261-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-38261-2_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-38260-5

  • Online ISBN: 978-3-030-38261-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics