Abstract
Low back pain is believed to affect 80% of the world’s population at some point in their lifetime. In the UK alone, it is one of the main causes of work absenteeism and decreased quality of life. Degenerative disc disease and intervertebral disc (IVD) herniation (i.e., “slipped disc”) are the main causes of low back pain and sciatica. Discectomy and microdiscectomy, two of the most commonly used surgical procedures, aim to remove the tissue exerting pressure on the nerves and thus relieve the pain. However, this is only a temporary solution as damage to the IVD is not repaired and may require additional surgical interventions. While this procedure is less aggressive in comparison to spinal disc arthroplasty and fusion, microdiscectomy still requires a down-time of 1–4 weeks post-surgery. Emerging treatments for IVD repair aim to address these concerns, novel NP and AF repair strategies are being developed based on novel additive manufacturing techniques.
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References
E. Gakidou, A. Afshin, A.A. Abajobir, K.H. Abate, C. Abbafati, K.M. Abbas, F. Abd-Allah, et al., Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet 390(10100), 1345–1422 (2017). https://doi.org/10.1016/S0140-6736(17)32366-8
S.I. Hay, A.A. Abajobir, K.H. Abate, C. Abbafati, K.M. Abbas, F. Abd-Allah, R.S. Abdulkader, et al., Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet 390(10100), 1260–1344 (2017). https://doi.org/10.1016/S0140-6736(17)32130-X
T. Vos, A.A. Abajobir, K.H. Abate, C. Abbafati, K.M. Abbas, F. Abd-Allah, R.S. Abdulkader, et al., Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the global burden of disease study 2016. Lancet 390(10100), 1211–1259 (2017). https://doi.org/10.1016/S0140-6736(17)32154-2
D. Hoy, C. Bain, G. Williams, L. March, P. Brooks, F. Blyth, A. Woolf, T. Vos, R. Buchbinder, A systematic review of the global prevalence of low back pain. Arthritis Rheum. 64(6), 2028–2037 (2012). https://doi.org/10.1002/art.34347
N. Maniadakis, A. Gray, The Economic Burden of Back Pain in the UK. Pain 84(1), 95–103 (2000). https://doi.org/10.1016/S0304-3959(99)00187-6
Higher Safety Executive, Work-Related Musculoskeletal Disorders (WRMSDs) Statistics in Great Britain 2017 (2017). www.hse.gov.uk/statistics/
S.D. Kuslich, C.L. Ulstrom, C.J. Michael, The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. Orthop. Clin. North Am. 22(2), 181–187 (1991). http://www.ncbi.nlm.nih.gov/pubmed/1826546
M.A. Falconer, M. McGeorge, A.C. Begg, Surgery of lumbar intervertebral disk protrusion a study of principles and results based upon one hundred consecutive cases submitted to operation. Br. J. Surg. 35(139), 225–249 (1948). https://doi.org/10.1002/bjs.18003513902
C. Hirsch, An attempt to diagnose the level of a disc lesion clinically by disc puncture. Acta Orthop. Scand. 18(1–4), 132–140 (1948). https://doi.org/10.3109/17453674908988964
C. Hirsch, B.-E. Ingelmark, M. Miller, The anatomical basis for low back pain: studies on the presence of sensory nerve endings in ligamentous, capsular and intervertebral disc structures in the human lumbar spine. Acta Orthop. Scand. 33(1–4), 1–17 (1963). https://doi.org/10.3109/17453676308999829
P. Suthar, R. Patel, C. Mehta, N. Patel, MRI evaluation of lumbar disc degenerative disease. J. Clin. Diagn. Res. 9(4), TC04–TC09 (2015). https://doi.org/10.7860/JCDR/2015/11927.5761
M.A. Adams, Basic science of spinal degeneration. Surgery (Oxford) 30(7), 347–350 (2012). https://doi.org/10.1016/j.mpsur.2012.05.003
J.F. Griffith, Y.-X.J. Wang, G.E. Antonio, K.C. Choi, A. Yu, A.T. Ahuja, P.C. Leung, Modified Pfirrmann grading system for lumbar intervertebral disc degeneration. Spine 32(24), E708–E712 (2007). https://doi.org/10.1097/BRS.0b013e31815a59a0
N. Inoue, A.A. Espinoza Orías, Biomechanics of intervertebral disk degeneration. Orthop. Clin. North Am. 42(4), 487–499 (2011). https://doi.org/10.1016/j.ocl.2011.07.001
C.W. Pfirrmann, A. Metzdorf, M. Zanetti, J. Hodler, N. Boos, Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26(1), 1873–1878 (2001). http://ovidsp.uk.ovid.com/sp-3.29.0b/ovidweb.cgi?QS2=434f4e1a73d37e8c1cc07622d116f5518708e831a67563782792778585912c423b083b35cc598ff51ea2c322ca5410c8cb97bfde3ae14188fb2fff5595e5fc205ba8d9168f76c77e4521176a20f8fe0b6d8acfb83b72d7f4b0e8e55fe70a2cbe69414ea203
J.P.G. Urban, S. Roberts, Degeneration of the intervertebral disc. Arthritis Res. Ther. 5(3), 120–130 (2003). https://doi.org/10.1186/AR629
D.F. Fardon, A.L. Williams, E.J. Dohring, F.R. Murtagh, S.L. Gabriel Rothman, G.K. Sze, Lumbar disc nomenclature: version 2.0: recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 14(11), 2525–2545 (2014). https://doi.org/10.1016/j.spinee.2014.04.022
G.D. Cramer, S.A. Darby, Clinical Anatomy of the Spine, Spinal Cord, and ANS (Elsevier Health Sciences, 2014)
R.N. Massa, F.B. Mesfin, Herniation, Disc. StatPearls (StatPearls Publishing, 2018), http://www.ncbi.nlm.nih.gov/pubmed/28722852
S.J. Atlas, R.A. Deyo, R.B. Keller, A.M. Chapin, D.L. Patrick, J.M. Long, D.E. Singer, The maine lumbar spine study, part II. 1-year outcomes of surgical and nonsurgical management of sciatica. Spine 21(15), 1777–1786 (1996). http://www.ncbi.nlm.nih.gov/pubmed/8855462
S.J. Atlas, R.B. Keller, Y. Chang, R.A. Deyo, D.E. Singer, Surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: five-year outcomes from the maine lumbar spine study. Spine 26(10), 1179–1187 (2001). http://www.ncbi.nlm.nih.gov/pubmed/11413434
S.J. Atlas, R.B. Keller, Y.A. Wu, R.A. Deyo, D.E. Singer, Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study. Spine 30(8), 927–935 (2005). http://www.ncbi.nlm.nih.gov/pubmed/15834338
M. Gugliotta, B.R. da Costa, E. Dabis, R. Theiler, P. Jüni, S. Reichenbach, H. Landolt, P. Hasler, Surgical versus conservative treatment for lumbar disc herniation: a prospective cohort study. BMJ Open 6(12), e012938 (2016). https://doi.org/10.1136/bmjopen-2016-012938
W.C.H. Jacobs, M. van Tulder, M. Arts, S.M. Rubinstein, M. van Middelkoop, R. Ostelo, A. Verhagen, B. Koes, W.C. Peul, Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review. Eur. Spine J. 20(4), 513–522 (2011). https://doi.org/10.1007/s00586-010-1603-7
R.B. Keller, S.J. Atlas, D.E. Singer, A.M. Chapin, N.A. Mooney, D.L. Patrick, R.A. Deyo, The maine lumbar spine study, Part I. background and concepts. Spine 21(15), 1769–1776 (1996). http://www.ncbi.nlm.nih.gov/pubmed/8855461
J.D. Lurie, S.C. Faucett, B. Hanscom, T.D. Tosteson, P.A. Ball, W.A. Abdu, J.W. Frymoyer, J.N. Weinstein, Lumbar Discectomy Outcomes Vary by Herniation Level in the Spine Patient Outcomes Research Trial. J. Bone Joint Surg. Am. 90(9), 1811–1819 (2008). https://doi.org/10.2106/JBJS.G.00913
J.A. Rihn, A.S. Hilibrand, K. Radcliff, M. Kurd, J. Lurie, E. Blood, T.J. Albert, J.N. Weinstein, Duration of Symptoms Resulting from Lumbar Disc Herniation: Effect on Treatment Outcomes: Analysis of the Spine Patient Outcomes Research Trial (SPORT). J. Bone Joint Surg. Am. 93(20), 1906–1914 (2011). https://doi.org/10.2106/JBJS.J.00878
A.J. Schoenfeld, J.D. Lurie, W. Zhao, C.M. Bono, The effect of race on outcomes of surgical or nonsurgical treatment of patients in the Spine Patient Outcomes Research Trial (SPORT). Spine 37(17), 1505–1515 (2012). https://doi.org/10.1097/BRS.0b013e318251cc78
A.J. Schoenfeld, B.K. Weiner, Treatment of lumbar disc herniation: evidence-based practice. Int. J. Gen. Med. 3(July), 209–214 (2010). http://www.ncbi.nlm.nih.gov/pubmed/20689695
A.N.A. Tosteson, T.D. Tosteson, J.D. Lurie, W. Abdu, H. Herkowitz, G. Andersson, T. Albert, et al., Comparative effectiveness evidence from the spine patient outcomes research trial: surgical versus nonoperative care for spinal stenosis, degenerative spondylolisthesis, and intervertebral disc herniation. Spine 36(24), 2061–2068 (2011). https://doi.org/10.1097/BRS.0b013e318235457b
H. Weber, Lumbar disc herniation. a controlled, prospective study with ten years of observation. Spine 8(2), 131–140 (1983). http://www.ncbi.nlm.nih.gov/pubmed/6857385
J.N. Weinstein, J.D. Lurie, T.D. Tosteson, J.S. Skinner, B. Hanscom, A.N.A. Tosteson, H. Herkowitz, et al., Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT) observational cohort. JAMA 296(20), 2451–2459 (2006). https://doi.org/10.1001/jama.296.20.2451
J.N. Weinstein, J.D. Lurie, T.D. Tosteson, A.N.A. Tosteson, E.A. Blood, W.A. Abdu, H. Herkowitz, A. Hilibrand, T. Albert, J. Fischgrund, Surgical versus nonoperative treatment for lumbar disc herniation: four-year results for the Spine Patient Outcomes Research Trial (SPORT). Spine 33(25), 2789–2800 (2008). https://doi.org/10.1097/BRS.0b013e31818ed8f4
J.N. Weinstein, T.D. Tosteson, J.D. Lurie, A. Tosteson, E. Blood, H. Herkowitz, F. Cammisa, et al., Surgical versus nonoperative treatment for lumbar spinal stenosis four-year results of the spine patient outcomes research trial. Spine 35(14), 1329–1338 (2010). https://doi.org/10.1097/BRS.0b013e3181e0f04d
J.N. Weinstein, T.D. Tosteson, J.D. Lurie, A.N.A. Tosteson, B. Hanscom, J.S. Skinner, W.A. Abdu, A.S. Hilibrand, S.D. Boden, R.A. Deyo, Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trial. JAMA 296(20), 2441–2450 (2006). https://doi.org/10.1001/jama.296.20.2441
E.J. Carragee, M.Y. Han, P.W. Suen, D. Kim, Clinical outcomes after lumbar discectomy for sciatica: the effects of fragment type and anular competence. J. Bone Joint Surg. Am. 85–A(1), 102–108 (2003). http://www.ncbi.nlm.nih.gov/pubmed/12533579
N. Lange, B. Meyer, E. Shiban, Symptomatic annulus-repair-device loosening due to a low-grade infection. Acta Neurochir. 160(1), 199–203 (2018). https://doi.org/10.1007/s00701-017-3371-1
T. Lee, T.-H. Lim, S.-H. Lee, J.-H. Kim, J. Hong, Biomechanical function of a balloon nucleus pulposus replacement system: a human cadaveric spine study. J. Orthop. Res. 36(1), 167–173 (2017). https://doi.org/10.1002/jor.23607
R.D. Bowles, L.A. Setton, Biomaterials for Intervertebral Disc Regeneration and Repair. Biomaterials 129(June), 54–67 (2017). https://doi.org/10.1016/J.BIOMATERIALS.2017.03.013
J.M. Cloyd, N.R. Malhotra, L. Weng, W. Chen, R.L. Mauck, D.M. Elliott, Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Eur. Spine J. 16(11), 1892–1898 (2007). https://doi.org/10.1007/s00586-007-0443-6
P. Roughley, C. Hoemann, E. DesRosiers, F. Mwale, J. Antoniou, M. Alini, The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation. Biomaterials 27(3), 388–396 (2006). https://doi.org/10.1016/J.BIOMATERIALS.2005.06.037
A.A. Thorpe, G. Dougill, L. Vickers, N.D. Reeves, C. Sammon, G. Cooper, C.L. Le Maitre, Thermally triggered hydrogel injection into bovine intervertebral disc tissue explants induces differentiation of mesenchymal stem cells and restores mechanical function. Acta Biomater. 54(May), 212–226 (2017). https://doi.org/10.1016/J.ACTBIO.2017.03.010
B.D. Ahlgren, W. Lui, H.N. Herkowitz, M.M. Panjabi, J.P. Guiboux, Effect of anular repair on the healing strength of the intervertebral disc: a sheep model. Spine 25(17), 2165–2170 (2000). http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=med4&NEWS=N&AN=10973397
A. Bartlett, L. Wales, R. Houfburg, W.K. Durfee, S.L. Griffith, I. Bentley, A. Bartlett, et al., Optimizing the effectiveness of a mechanical suture-based anulus fibrosus repair construct in an acute failure laboratory simulation. J. Spinal Disord. Tech. 26(7), 393–399 (2013). https://doi.org/10.1097/BSD.0b013e31824c8224
A.H. Bateman, C. Balkovec, M.K. Akens, A.H.W.W. Chan, R.D. Harrison, W. Oakden, A.J.M.M. Yee, S.M. McGill, Closure of the annulus fibrosus of the intervertebral disc using a novel suture application device—in vivo porcine and ex vivo biomechanical evaluation. Spine J. 16(7), 889–895 (2016). https://doi.org/10.1016/j.spinee.2016.03.005
C.-J. Chiang, C.-K. Cheng, J.-S. Sun, C.-J. Liao, Y.-H. Wang, Y.-H. Tsuang, The effect of a new anular repair after discectomy in intervertebral disc degeneration: an experimental study using a porcine spine model. Spine 36(10), 761–769 (2011). https://doi.org/10.1097/BRS.0b013e3181e08f01
Y.-F. Chiang, C.-J. Chiang, C.-H. Yang, Z.-C. Zhong, C.-S. Chen, C.-K. Cheng, Y.-H. Tsuang, Retaining intradiscal pressure after annulotomy by different annular suture techniques, and their biomechanical evaluations. Clin. Biomech. 27(3), 241–248 (2012). https://doi.org/10.1016/j.clinbiomech.2011.09.008
F. Heuer, S. Ulrich, L. Claes, H.-J. Wilke, Biomechanical evaluation of conventional anulus fibrosus closure methods required for nucleus replacement. laboratory investigation. journal of neurosurgery. Spine 9(3), 307–313 (2008). https://doi.org/10.3171/SPI/2008/9/9/307
L. Qi, M. Li, H. Si, L. Wang, Y. Jiang, S. Zhang, The Clinical application of ‘jetting suture’ technique in annular repair under microendoscopic discectomy: a prospective single-cohort observational study. Medicine (United States) 95(31), e4503 (2016). https://doi.org/10.1097/MD.0000000000004503
M.N. Melkerson, Xclose Tissue Repair System 510(k) Premarket Notification (2009), https://www.accessdata.fda.gov/cdrh_docs/pdf9/K091432.pdf
M.N. Melkerson, Inclose Surgical Mesh System 510(K) Summary of Safety and Effectiveness (2005), https://www.accessdata.fda.gov/cdrh_docs/pdf5/K050969.pdf
P. Grunert, B.H. Borde, S.B. Towne, Y. Moriguchi, K.D. Hudson, L.J. Bonassar, R. Härtl, Riboflavin crosslinked high-density collagen gel for the repair of annular defects in intervertebral discs: an in vivo study. Acta Biomater. 26, 215–224 (2015). https://doi.org/10.1016/j.actbio.2015.06.006
C.C. Guterl, O.M. Torre, D. Purmessur, K. Dave, M. Likhitpanichkul, A.C. Hecht, S.B. Nicoll, J.C. Iatridis, Characterization of mechanics and cytocompatibility of fibrin-genipin annulus fibrosus sealant with the addition of cell adhesion molecules. Tissue Eng. A 20(17–18), 2536–2545 (2014). https://doi.org/10.1089/ten.tea.2012.0714
M. Likhitpanichkul, M. Dreischarf, S. Illien-Junger, B.A. Walter, T. Nukaga, R.G. Long, D. Sakai, A.C. Hecht, J.C. Iatridis, Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests. Eur. Cell Mater. 28, 25–28 (2014). http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a03.pdf
P. Grunert, B. Borde, M. Macielak, K. Hudson, M. Alimi, L. Bonassar, P. Grunert, et al., Annular repair using high density collagen gel: in vivo outcome in a rodent spine model. Spine J. 13(9 SUPPL. 1), 51S (2013). https://doi.org/10.1016/j.spinee.2013.07.152
P.-P.A. Vergroesen, A.I. Bochyn Ska, K.S. Emanuel, S. Sharifi, I. Kingma, D.W. Grijpma, T.H. Smit, A biodegradable glue for annulus closure: evaluation of strength and endurance. Spine 40(9), 622–628 (2015). https://doi.org/10.1097/BRS.0000000000000792
M.A. Cruz, S. McAnany, N. Gupta, R.G. Long, P. Nasser, D. Eglin, A.C. Hecht, S. Illien-Junger, J.C. Iatridis, Structural and chemical modification to improve adhesive and material properties of fibrin-genipin for repair of annulus fibrosus defects in intervertebral disks. J. Biomech. Eng. 139(8), 0845011–0845017 (2017). https://doi.org/10.1115/1.4036623
M. Likhitpanichkul, Y. Kim, O.M. Torre, E. See, Z. Kazezian, A. Pandit, A.C. Hecht, J.C. Iatridis, Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug. Spine J. 15(9), 2045–2054 (2015). https://doi.org/10.1016/j.spinee.2015.04.026
R. Kang, H. Li, H. Lysdahl, D. Quang Svend Le, M. Chen, L. Xie, Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: mechanical and biocompatible evaluation. J. Biomed. Mater. Res. B Appl. Biomater. 105(1), 14–20 (2017). https://doi.org/10.1002/jbm.b.33524
J.L. Bron, A.J. Van Der Veen, M.N. Helder, B.J. Van Royen, T.H. Smit, Biomechanical and in vivo evaluation of experimental closure devices of the annulus fibrosus designed for a goat nucleus replacement model. Eur. Spine J. 19(8), 1347–1355 (2010). https://doi.org/10.1007/s00586-010-1384-z
T.K. Chik, X.Y. Ma, T.H. Choy, Y.Y. Li, H.J. Diao, W.K. Teng, S.J. Han, K.M.C. Cheung, B.P. Chan, Photochemically crosslinked collagen annulus plug: a potential solution solving the leakage problem of cell-based therapies for disc degeneration. Acta Biomater. 9(9), 8128–8139 (2013). https://doi.org/10.1016/j.actbio.2013.05.034
E.H. Ledet, W. Jeshuran, J.C. Glennon, C. Shaffrey, P. De Deyne, C. Belden, B. Kallakury, A.L. Carl, Small intestinal submucosa for anular defect closure: long-term response in an in vivo sheep model. Spine 34(14), 1457–1463 (2009). https://doi.org/10.1097/BRS.0b013e3181a48554
D.A. Wong, L. Mauter, V. Murdock, C.J. Wong, Variations in Anular Defect characteristics in herniated lumbar discs: a feasibility study of anular repair and an attempt to confirm carragee population data on defect size. Spine J. 10(9), S47 (2010). https://doi.org/10.1016/j.spinee.2010.07.129
S. Sharifi, S.K. Bulstra, D.W. Grijpma, R. Kuijer, Treatment of the degenerated intervertebral disc; closure, repair and regeneration of the annulus fibrosus. J. Tissue Eng. Regen. Med. 9(10), 1120–1132 (2015). https://doi.org/10.1002/term.1866
A. Bailey, A. Araghi, S. Blumenthal, G.V. Huffmon, Anular Repair Clinical Study Group, Prospective, multicenter, randomized, controlled study of anular repair in lumbar discectomy: two-year follow-up. Spine 38(14), 1161–1169 (2013). https://doi.org/10.1097/BRS.0b013e31828b2e2f. [Erratum appears in Spine (Phila Pa 1976). 2013 Aug 1;38(17):1527]
B. Borde, P. Grunert, R. Härtl, L.J. Bonassar, Injectable, high-density collagen gels for annulus fibrosus repair: an in vitro rat tail model. J. Biomed. Mater. Res. A 103(8), 2571–2581 (2015). https://doi.org/10.1002/jbm.a.35388
B. Pennicooke, I. Hussain, C. Berlin, S.R. Sloan, B. Borde, Y. Moriguchi, G. Lang, et al., Annulus fibrosus repair using high-density collagen gel: an in vivo ovine model. Spine 43(4), E208–E215 (2017). https://doi.org/10.1097/BRS.0000000000002334
R.G. Long, O.M. Torre, W.W. Hom, D.J. Assael, J.C. Iatridis, Design requirements for annulus fibrosus repair: review of forces, displacements, and material properties of the intervertebral disk and a summary of candidate hydrogels for repair. J. Biomech. Eng. 138(2), 021007 (2016). https://doi.org/10.1115/1.4032353
C. Wiltsey, T. Christiani, J. Williams, J. Scaramazza, C. Van Sciver, K. Toomer, J. Sheehan, et al., thermogelling bioadhesive scaffolds for intervertebral disk tissue engineering: preliminary in vitro comparison of aldehyde-based versus alginate microparticle-mediated adhesion. Acta Biomater. 16(April), 71–80 (2015). https://doi.org/10.1016/j.actbio.2015.01.025
B. Akgun, S. Ozturk, H. Cakin, M. Kaplan, Migration of fragments into the spinal canal after intervertebral polyethylene glycol implantation: an extremely rare adverse effect. J. Neurosurg. Spine 21(4), 614–616 (2014). https://doi.org/10.3171/2014.6.SPINE13855
N.L. Nerurkar, B.M. Baker, S. Sen, E.E. Wible, D.M. Elliott, R.L. Mauck, Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nat. Mater. 8(12), 986–992 (2009). https://doi.org/10.1038/nmat2558
U. Boudriot, R. Dersch, A. Greiner, J.H. Wendorff, Electrospinning approaches toward scaffold engineering: a brief overview. Artif. Organs 30(10), 785–792 (2006). https://doi.org/10.1111/j.1525-1594.2006.00301.x
N. Wismer, S. Grad, G. Fortunato, S.J. Ferguson, M. Alini, D. Eglin, Biodegradable electrospun scaffolds for annulus fibrosus tissue engineering: effect of scaffold structure and composition on annulus fibrosus cells in vitro. Tissue Eng. A 20(3-4), 672–682 (2014). https://doi.org/10.1089/ten.tea.2012.0679
L. Koepsell, T. Remund, J. Bao, D. Neufeld, H. Fong, Y. Deng, Tissue engineering of annulus fibrosus using electrospun fibrous scaffolds with aligned polycaprolactone fibers. J. Biomed. Mater. Res. A 99A(4), 564–575 (2011). https://doi.org/10.1002/jbm.a.33216
L. Koepsell, L. Zhang, D. Neufeld, H. Fong, Y. Deng, Electrospun nanofibrous polycaprolactone scaffolds for tissue engineering of annulus fibrosus. Macromol. Biosci. 11(3), 391–399 (2011). https://doi.org/10.1002/mabi.201000352
N.L. Nerurkar, D.M. Elliott, R.L. Mauck, Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. J. Orthop. Res. 25(8), 1018–1028 (2007). https://doi.org/10.1002/jor.20384
F.P.W. Melchels, J. Feijen, D.W. Grijpma, A review on stereolithography and its applications in biomedical engineering. Biomaterials 31(24), 6121–6130 (2010). https://doi.org/10.1016/J.BIOMATERIALS.2010.04.050
S.B. Blanquer, A.W. Gebraad, S. Miettinen, A.A. Poot, D.W. Grijpma, S.P. Haimi, Differentiation of adipose stem cells seeded towards annulus fibrosus cells on a designed poly(trimethylene carbonate) scaffold prepared by stereolithography. J. Tissue Eng. Regen. Med. 11(10), 2752–2762 (2017). https://doi.org/10.1002/term.2170
Z. Li, T. Pirvu, L.M. Benneker, S.B.G. Blanquer, D.W. Grijpma, M. Alini, D. Eglin, A combined cellular and biomaterial approach for restoration of disc height and prevention of degeneration in annulotomized disc. Eur. Spine J. 9, 2501 (2014). https://doi.org/10.1007/s00586-014-3600-8
M. Hospodiuk, M. Dey, D. Sosnoski, I.T. Ozbolat, The bioink: a comprehensive review on bioprintable materials. Biotechnol. Adv. 35(2), 217–239 (2017). https://doi.org/10.1016/J.BIOTECHADV.2016.12.006
J.B. Costa, J. Silva-Correia, V.P. Ribeiro, A. da Silva Morais, J.M. Oliveira, R.L. Reis, Engineering patient-specific bioprinted constructs for treatment of degenerated intervertebral disc. Mater. Today Commun. 19, 506–512 (2018). https://doi.org/10.1016/j.mtcomm.2018.01.011
S.R. Sloan, D. Galesso, C. Secchieri, C. Berlin, R. Hartl, L.J. Bonassar, Initial investigation of individual and combined annulus fibrosus and nucleus pulposus repair ex vivo. Acta Biomater. 59, 192–199 (2017). https://doi.org/10.1016/j.actbio.2017.06.045
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Alcántara Guardado, A., Cooper, G. (2021). Low Back Pain: Additive Manufacturing for Disc Degeneration and Herniation Repair. In: Bidanda, B., Bártolo, P.J. (eds) Virtual Prototyping & Bio Manufacturing in Medical Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-35880-8_9
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