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Therapeutic Drug Monitoring in Saliva

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Salivary Bioscience

Abstract

Blood monitoring of therapeutic drugs is frequently used in clinical settings for the purpose of optimizing drug therapy. Psychotropic and psychiatric medications are used to treat a variety of mental health conditions, including depression, anxiety, bipolar disorder, and schizophrenia. Saliva is gaining increasing attention as a bioanalytical sample matrix for drug monitoring, including monitoring of psychotropic medications. Much of the advantages of saliva sampling come from the easy and noninvasive nature of saliva collection, which has clear advantages over blood draws, especially in pediatric populations or when frequent monitoring is required. Great improvements in the development of accurate and reliable methods for sample collection and highly sensitive and specific analytical methods for saliva testing of drugs have been observed in recent years. This chapter will review studies supporting the applicability of saliva for monitoring of psychotropic drugs, including antidepressants, mood stabilizers, and antipsychotic drugs. Further, this chapter will cover the main technological advances over the last decade, which have made oral fluid analysis of drugs possible.

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  1. Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA

    Elizabeth A. Thomas

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  1. Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA, USA

    Douglas A. Granger

  2. Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA, USA

    Marcus K. Taylor

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Thomas, E.A. (2020). Therapeutic Drug Monitoring in Saliva. In: Granger, D., Taylor, M. (eds) Salivary Bioscience. Springer, Cham. https://doi.org/10.1007/978-3-030-35784-9_17

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