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Feline Atopic Syndrome: Therapy

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Feline Dermatology
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Abstract

Feline allergic dermatitis is a chronic disease and allergen avoidance, when possible, is the best management option. If this is not possible, then a combination of aetiologic, symptomatic, topical, antimicrobial and nutritional therapy is implemented, depending on the individual case. Aetiologic therapy is based on allergy test and hyposensitization, which will be curative only in a minority of cases. All other cases will need some sort of symptomatic therapy, possibly avoiding long-term administration of glucocorticoids. Alternative systemic treatments include ciclosporin, antihistamines, oclacitinib, palmitoylethanolamide, maropitant and PUFAs: not all of these are effective in every case and some are not registered for the cat. Topical treatments are not easy to apply in cats and only a few studies confirm their efficacy. The pros and cons of allergy testing and hyposensitization, and of topical and/or systemic symptomatic treatment will be discussed in this chapter.

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References

  1. Noli C, Borio S, Varina A, et al. Development and validation of a questionnaire to evaluate the quality of life of cats with skin disease and their owners, and its use in 185 cats with skin disease. Vet Dermatol. 2016;27:247–e58.

    PubMed  Google Scholar 

  2. Noli C, Ortalda C, Galzerano M. L’utilizzo della ciclosporina in formulazione liquida (Atoplus gatto®) nel trattamento delle malattie allergiche feline. Veterinaria (Cremona). 2014;28:15–22.

    Google Scholar 

  3. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood induced hypersensitivity dermatitis. Vet Dermatol. 2019;30:110–e30.

    Google Scholar 

  4. Diesel A, DeBoer DJ. Serum allergen-specific immunoglobulin E in atopic and healthy cats: comparison of a rapid screening immunoassay and complete-panel analysis. Vet Dermatol. 2011;22:39–45.

    PubMed  Google Scholar 

  5. Bexley J, Hogg JE, Hammerberg B, et al. Levels of house dust mite-specific serum immunoglobulin E (IgE) in different cat populations using a monoclonal based anti-IgE enzyme-linked immunosorbent assay. Vet Dermatol. 2009;20:562–8.

    PubMed  Google Scholar 

  6. Gilbert S, Halliwell REW. Feline immunoglobulin E: induction of antigen-specific antibody in normal cats and levels in spontaneously allergic cats. Vet Immunol Immunopathol. 1998;63:235–52.

    CAS  PubMed  Google Scholar 

  7. Taglinger K, Helps CR, Day MJ, et al. Measurement of serum immunoglobulin E (IgE) specific for house dust mite antigens in normal cats and cats with allergic skin disease. Vet Immunol Immunopathol. 2005;105:85–93.

    CAS  PubMed  Google Scholar 

  8. Kadoya-Minegishi M, Park SJ, Sekiguchi M, et al. The use of fluorescein as a contrast medium to enhance intradermal skin tests in cats. Austr Vet J. 2002;80:702–3.

    CAS  Google Scholar 

  9. Schleifer SG, Willemse T. Evaluation of skin test reactivity to environmental allergens in healthy cats and cats with atopic dermatitis. Am J Vet Res. 2003;64:773–8.

    PubMed  Google Scholar 

  10. Scholz FM, Burrows AK, Griffin CE, Muse R. Determination of threshold concentrations of plant pollens in intradermal testing using fluorescein in clinically healthy nonallergic cats. Vet Dermatol. 2017;28:351–e78.

    PubMed  Google Scholar 

  11. Willemse T, Vroom MW, Mol JA, Rijnberk A. Changes in plasma cortisol, corticotropin, and alpha-melanocyte-stimulating hormone concentrations in cats before and after physical restraint and intradermal testing. Am J Vet Res. 1993;54:69–72.

    CAS  PubMed  Google Scholar 

  12. Rossi MA, Messinger L, Olivry T, Hoontrakoon R. A pilot study of the validation of percutaneous testing in cats. Vet Dermatol. 2013 Oct;24:488–e115.

    PubMed  Google Scholar 

  13. Gentry CM, Messinger L. Comparison of intradermal and percutaneous testing to histamine, saline and nine allergens in healthy adult cats. Vet Dermatol. 2016;27:370–e92.

    PubMed  Google Scholar 

  14. Swinnen C, Vroom M. The clinical effect of environmental control of house dust mites in 60 house dust mite-sensitive dogs. Vet Dermatol. 2004;15:31–6.

    PubMed  Google Scholar 

  15. Mueller RS, Jensen-Jarolim E, Roth Walter F, et al. Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs. Allergy. 2018;. early view online;73:1989. https://doi.org/10.1111/all.13464.

    Article  CAS  PubMed  Google Scholar 

  16. Carlotti D, Prost C. L’atopie féline. Le Point Vétérinaire. 1988;20:777–84.

    Google Scholar 

  17. Trimmer AM, Griffin CE, Rosenkrantz WS. Feline immunotherapy. Clin Techniques Small An Pract. 2006;21:157–61.

    Google Scholar 

  18. Ravens PA, Xu BJ, Vogelnest LJ. Feline atopic dermatitis: a retrospective study of 45 cases (2001-2012). Vet Dermatol. 2014;25:95–102.

    PubMed  Google Scholar 

  19. Reedy LM. Results of allergy testing and hyposensitization in selected feline skin diseases. J Am Anim Hosp Assoc. 1982;18:618–23.

    Google Scholar 

  20. Löewenstein C, Mueller RS. A review of allergen-specific immunotherapy in human and veterinary medicine. Vet Dermatol. 2009;20:84–98.

    PubMed  Google Scholar 

  21. Vidémont E, Pin D. How to treat atopy in cats? Eur J Comp An Pract. 2009;19:276–82.

    Google Scholar 

  22. Trimmer AM, Griffin CE, Boord MJ, et al. Rush allergen specific immunotherapy protocol in feline atopic dermatitis: a pilot study of four cats. Vet Dermatol. 2005;16:324–9.

    PubMed  Google Scholar 

  23. Broek AHM, Stafford WL. Epidermal and hepatic glucocorticoid receptors in cats and dogs. Res Vet Sci. 1992;52:312–5.

    PubMed  Google Scholar 

  24. Graham-Mize CA, Rosser EJ, Hauptman J. Absorption, bioavailability and activity of prednisone and prednisolone in cats. In: Hiller A, Foster AP, Kwochka KW, editors. Advances in veterinary dermatology, vol. 5. Oxford: Blackwell; 2005. p. 152–8.

    Google Scholar 

  25. Ganz EC, Griffin CE, Keys DA, et al. Evaluation of methylprednisolone and triamcinolone for the induction and maintenance treatment of pruritus in allergic cats: a double-blinded, randomized, prospective study. Vet Dermatol. 2012;23:387–e72.

    PubMed  Google Scholar 

  26. Lowe AD, Campbell KL, Graves T. Glucocorticoids in the cat. Vet Dermatol. 2008;19:340–7.

    PubMed  Google Scholar 

  27. Lockwood SL, Schick AE, Lewis TP, Newton H. Investigation of subclinical bacteriuria in cats with dermatological disease receiving long-term glucocorticoids and/or ciclosporin. Vet Dermatol. 2018;29:25–e12.

    PubMed  Google Scholar 

  28. Schmidt V, Buckley LM, McEwan NA, Rème CA, Nuttall TJ. Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: an open label pilot study. Vet Dermatol 2012; 23: 11–6, e3–4.

    Google Scholar 

  29. Wisselink MA, Willemse T. The efficacy of cyclosporine a in cats with presumed atopic dermatitis: a double blind, randomized prednisolone-controlled study. Vet J. 2009;180:55–9.

    CAS  PubMed  Google Scholar 

  30. King S, Favrot C, Messinger L, et al. A randomized double-blinded placebo-controlled study to evaluate an effective ciclosporin dose for the treatment of feline hypersensitivity dermatitis. Vet Dermatol. 2012;23:440–e84.

    PubMed  Google Scholar 

  31. Roberts ES, Speranza C, Friberg C, et al. Confirmatory field study for the evaluation of ciclosporin at a target dose of 7.0 mg/kg (3.2 mg/lb) in the control of feline hypersensitivity dermatitis. J Feline Med Surg. 2016;18:889–97.

    PubMed  Google Scholar 

  32. Steffan J, Roberts E, Cannon A, et al. Dose tapering for ciclosporin in cats with nonflea-induced hypersensitivity dermatitis. Vet Dermatol. 2013;24:315–22.

    PubMed  PubMed Central  Google Scholar 

  33. Roberts ES, Tapp T, Trimmer A, et al. Clinical efficacy and safety following dose tapering of ciclosporin in cats with hypersensitivity dermatitis. J Feline Med Surg. 2016;18:898–905.

    PubMed  Google Scholar 

  34. Panteri A, Strehlau G, Helbig R, et al. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Vet Dermatol. 2016;27:22–e7.

    PubMed  Google Scholar 

  35. Dip R, Carmichael J, Letellier I, et al. Concurrent short-term use of prednisolone with cyclosporine A accelerates pruritus reduction and improvement in clinical scoring in dogs with atopic dermatitis. BMC Vet Res. 2013;3(9):173.

    Google Scholar 

  36. Steffan J, King S, Seewald W. Ciclosporin efficacy in the treatment of feline hypersensitivity dermatitis is not influenced by the feeding status. Vet Dermatol. 2012;23(suppl. 1):64–5. (abstract)

    Google Scholar 

  37. Koch SN, Torres SMF, Diaz S, et al. Subcutaneous administration of ciclosporin in 11 allergic cats – a pilot open-label uncontrolled clinical trial. Vet Dermatol. 2018;29:107–e43.

    PubMed  Google Scholar 

  38. Heinrich NA, McKeever PJ, Eisenschenk MC. Adverse events in 50 cats with allergic dermatitis receiving ciclosporin. Vet Dermatol. 2011;22:511–20.

    PubMed  Google Scholar 

  39. Last RD, Suzuki Y, Manning T. A case of fatal systemic toxoplasmosis in a cat being treated with cyclosporin a for feline atopy. Vet Dermatol. 2004;15:194–8.

    PubMed  Google Scholar 

  40. Scott DW, Miller WH Jr. Antihistamines in the management of allergic pruritus in dogs and cats. J Small Anim Pract. 1999;40:359–64.

    CAS  PubMed  Google Scholar 

  41. Papich MG, Schooley EK, Reinero CR. Pharmacokinetics of cetirizine in healthy cats. Am J Vet Res. 2008;69:670–4.

    CAS  PubMed  Google Scholar 

  42. Griffin JS, Scott DW, Miller WH Jr, et al. An open clinical trial on the efficacy of cetirizine hydrochloride in the management of allergic pruritus in cats. Can Vet J. 2012;53:47–50.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Wildermuth K, Zabel S, Rosychuk RA. The efficacy of cetirizine hydrochloride on the pruritus of cats with atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover study. Vet Dermatol. 2013;24:576–681, e137-8.

    PubMed  Google Scholar 

  44. Ortalda C, Noli C, Colombo S, Borio S. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. Vet Dermatol. 2015;26:235–e52.

    PubMed  Google Scholar 

  45. Lopes NL, Campos DR, Machado MA, Alves MSR, de Souza MSG, da Veiga CCP, Merlo A, Scott FB, Fernandes JI. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. BMC Vet Res. 2019;15(1):137.

    Google Scholar 

  46. Scarampella F, Abramo F, Noli C. Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study. Vet Dermatol. 2001 Feb;12(1):29–39.

    CAS  PubMed  Google Scholar 

  47. Noli C, Della Valle MF, Miolo A, Medori C, Schievano C; Skinalia Clinical Research Group. Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double-blind, multicentre, randomized, placebo-controlled study.Vet Dermatol. 2019;30:387–e117.

    Google Scholar 

  48. Maina E, Fontaine J. Use of maropitant for the control of pruritus in non-flea, non-food-induced feline hypersensitivity dermatitis: an open label uncontrolled pilot study. J Feline Med Surg. 2019;21:967–72.

    Google Scholar 

  49. Harvey RG. Management of feline miliary dermatitis by supplementing the diet with essential fatty acids. Vet Rec. 1991;128:326–9.

    CAS  PubMed  Google Scholar 

  50. Harvey RG. The effect of varying proportions of evening primrose oil and fish oil on cats with crusting dermatosis (miliary dermatitis). Vet Rec. 1993a;133:208–11.

    CAS  PubMed  Google Scholar 

  51. Harvey RG. A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. Vet Rec. 1993b;133:571–3.

    CAS  PubMed  Google Scholar 

  52. Miller WH, Scott DW, Wellington JR. Efficacy of DVM Derm caps liquid in the management of allergic and inflammatory dermatoses of the cat. JAAHA. 1993;29:37–40.

    Google Scholar 

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Noli, C. (2020). Feline Atopic Syndrome: Therapy. In: Noli, C., Colombo, S. (eds) Feline Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-29836-4_23

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