Abstract
Chemical crowd control agents (CCCAs) are used to produce temporary incapacitation of an individual or a group of individuals without the need for physical force. Whilst use of these agents is relatively benign, there are reports of serious toxicity typically when these agents have been used at high concentration, in confined spaces, or through prolonged exposure. A wide variety of physiological effects may result, with the most common clinical findings being pain, burning, and irritation of exposed mucous membranes and skin. More lethal methods of chemical control may be used, with exposure to fentanyl (and derivatives) and nerve agents discussed. Individuals will often present in extremis quickly after exposure to these more potent chemicals, and recognition of signs and symptoms of their toxicity is important to enable timely administration of antidotes. With all these chemicals it is also important to understand the risk they pose to healthcare professionals and the appropriate measures that should be taken to minimise the chance of secondary exposure.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pilant L (1993) Less-than-lethal weapons: new solutions for law enforcement. In: Science and technology. Washington, DC, International Association of Chiefs of Police
Haar RJ, Iacopino V, Ranadive N, Weiser SD, Dandu M (2017) Health impacts of chemical irritants used for crowd control: a systematic review of the injuries and deaths caused by tear gas and pepper spray. BMC Public Health 17:831
Toprak S, Ersoy G, Hart J, Clevestig P (2015) The pathology of lethal exposure to the riot control agents: towards a forensics-based methodology for determining misuse. J Forensic Legal Med 29:36–42
Kim YJ, Payal AR, Daly MK (2016) Effects of tear gases on the eye. Surv Ophthalmol 61:434–442
Satpute RM, Kushwaha PK, Nagar DP, Rao PVL (2018) Comparative safety evaluation of riot control agents of synthetic and natural origin. Inhal Toxicol 30:89–97
Olajos EJ, Salem H (2001) Riot control agents: pharmacology, toxicology, biochemistry and chemistry. J Appl Toxicol 21:355e91
Southward RD (2000) CS incapacitant spray. J Accid Emerg Med 17:76
Euripidou E, MacLehose R, Fletcher A (2004) An investigation into the short term and medium term health impacts of personal incapacitant sprays. A follow up of patients reported to the National Poisons Information Service (London). Emerg Med J 21:548–552
ACPO (Association of Chief Police Officers of England, Wales and Northern Ireland) (2009) Guidance on the use of incapacitant spray. London, England. http://www.npcc.police.uk/documents/FoI%20publication/Disclosure%20Logs/Uniformed%20Operations%20FOI/2013/003%2013%20Att%2014%20of%2015%20Guidance%20on%20the%20use%20of%20Incapacitant%20Spray.pdf. Accessed 06 Apr 2019
Reilly CA, Crouch DJ, Yost GS (2001) Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products. J Forensic Sci 46:502–509
Holopainen JM, Moilanen JA, Hack T, Tervo TM (2003) Toxic carriers in pepper sprays may cause corneal erosion. Toxicol Appl Pharmacol 186:155–162
Derbeken V (1997) Pepper spray in the eyes – protestors file suit against police. In: San Francisco chronicle. Herst Publications, San Francisco, CA
Pearson A (2006) Incapacitating biochemical weapons. Nonproliferation Rev 13:151–188
Sutter ME, Gerona RR, Davis MT, Roche BM, Colby DK, Chenoweth JA, Adams AJ, Owen KP, Ford JB, Black HB, Albertson TE (2017) Fatal fentanyl: one pill can kill. Acad Emerg Med 24:106–113
Wax PM, Becker CE, Curry SC (2003) Unexpected “gas” casualties in Moscow: a medical toxicology perspective. Ann Emerg Med 41:700–705
Gross ML (2009) Non-lethal weapons and the civilian death toll in war time. Nature 461:340
Riches JR, Read RW, Black RM, Cooper NJ, Timperley CM (2012) Analysis of clothing and urine from Moscow theatre siege casualties reveals Carfentanil and remifentanil use. J Anal Toxicol 36:647–656
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824
Reilly CA, Taylor JL, Lanza DL, Carr BA, Crouch DJ, Yost GS (2003) Capsaicinoids cause inflammation and epithelial cell damage through activation of vanilloid receptors. Toxicol Sci 73:170–181
Worthington E, Nee P (1999) CS exposure – clinical effects and management. J Accid Emerg Med 16:168–170
Schep LJ, Slaughter RJ, McBride DI (2015) Riot control agents: the tear gases CN, CS and OC - a medical review. J R Army Med Corps 161:94–99
Brône B, Peeters PJ, Marrannes R, Mercken M, Nuydens R, Meert T, Gijsen HJM (2008) Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol 231:150–156
Menezes RG, Hussain SA, Rameez MA, Kharoshah MA, Madadin M, Anwar N, Senthilkumaran S (2016) Chemical crowd control agents. Med Leg J 84:22–25
FFLM; McGorrigan J, Payne-James JJ (2017) Recommendations: Irritant sprays : clinical effects and management. https://fflm.ac.uk/wp-content/uploads/2018/08/Irritant-sprays-Dr-J-McGorrigan-and-Dr-J-Payne-James-December-2017.pdf. Accessed 06 Apr 2019
Breakell A, Bodiwala GG (1998) CS gas exposure in a crowded night club: the consequences for an accident and emergency department. J Accid Emerg Med. 15:56e7
Himsworth H, Dornhorst HC, Thompson RHS (1969) Report of an enquiry into the medical and toxicological aspects of CS (orthochlorohenzylidene malononitrile). Part I. Enquiry into the medical situation following the use of CS in Londonderry on the 13 and 14 august 1969. HMSO, London
Hu H, Fine J, Epstein P, Kelsey K, Reynolds P, Walker B (1989) Tear gas - harassing agent or toxic chemical weapon? JAMA 262:660–663
Fraunfelder FT (2000) Is CS gas dangerous? Current evidence suggests not but unanswered questions remain. BMJ 320:458–459
Hilmas CJ, Poole MJ, Katos AM, Williams PT (2009) Chapter 12: Riot control agents. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents. Academic Press, Cambridge, MA
Watson WA, Stremel KR, Westdorp EJ (1996) Oleoresin capsicum (cap-stun) toxicity from aerosol exposure. Ann Pharmacother 30:733–735
Solomon I, Kochba I, Marharshak N (2003) Report of accidental ingestion among seven patients in Central Israel and review of the current literature. Arch Toxicol 77:601–604
Lee RJ, Yolton RL, Yolton DP, Schnider C, Janin ML (1996) Personal defense sprays: effects and management of exposure. J Am Optom Assoc 67:548–560
Blain PG (2003) Tear gases and irritant incapacitants. 1-chloroacetophenone, 2-chlorobenzylidene malononitrile and dibenz[b,f]-1,4-oxazepine. Toxicol Rev 22:103e10
Agrawal Y, Thornton D, Phipps A (2009) CS gas – completely safe? A burn case report and literature review. Burns 35:895–897
Kiel AW (1997) Ocular exposure to CS gas: the importance of correct early management. Eye 11:759e60
Yih JP (1995) CS gas injury to the eye. BMJ 311:276
Beswick FW (1983) Chemical agents used in riot control and warfare. Hum Toxicol 2:247–256
Thomas RJ, Smith PA, Rascona DA, Louthan JD, Gumpert B (2002) Acute pulmonary effects from o-chlorobenzylidenemalonitrile “tear gas”: a unique exposure outcome unmasked by strenuous exercise after a military training event. Mil Med 167:136–139
Billmire DF, Vinocur C, Ginda M, Robinson NB, Panitch H, Friss H, Rubenstein D, Wiley JF (1996) Pepper-spray induced respiratory failure treated with extracorporeal membrane oxygenation. Pediatrics 98:961–963
Winograd HL (1977) Acute croup in an older child: an unusual toxin origin. Clin Pediatr 16:884–887
Holland P, White G (1972) The cutaneous reactions produced by o-chlorobenzyl-idenemalononitrile and –chloroacetophenone when applied directly to the skin of human subjects. Br J Dermatol 86:150–154
Çorbacɩoğlu ŞK, Güler S, Er E, Seviner M, Aslan Ş, Aksel G (2016) Rare and severe maxillofacial injury due to tear gas capsules: report of three cases. J Forensic Sci 61:551–554
Chan TC, Vilke GM, Neuman T (2000) Restraint position and positional asphyxia. Am J Forensic Med Pathol 21:93
Karch SB, Stephens BG (1999) Drug abusers who die in custody. J R Soc Med 92:110–113
Maeda H, Michiue T, Zhu B-L, Ishikawa T, Quan L, Bessho Y, Okazaki S, Kamikodai Y, Tsuda K, Komatsu A, Azuma Y (2009) Potential risk factors for sudden cardiac death: an analysis of medicolegal autopsy cases. Legal Med 11:S263–S265
Chan TC, Vilke GM, Clausen J, Clark RF, Schmidt P, Snowden T, Neuman T (2002) The effect of oleoresin capsicum “pepper” spray inhalation on respiratory function. J Forensic Sci 47:299–304
The Organisation for the Prohibition of Chemical Weapons (1994) Convention on the prohibition of the development, production, stockpiling and use of chemical weapons and on their destruction: Article II, section 7. https://www.opcw.org/sites/default/files/documents/CWC/CWC_en.pdf. Accessed 06 Apr 2019
Candiotti K (2017) A primer on nerve agents: what the emergency responder, anesthesiologist, and intensivist needs to know. Can J Anaesth 64:1059–1070
Ellison DH (2008) Handbook of chemical and biological warfare agents, 2nd edn. CRC Press, Boca Raton, FL
Anderson PD (2012) Emergency management of chemical weapons injuries. J Pharm Pract 25:61–68
Shimada M, Young C, Tanen DA (2012) Corneal ulcer associated with pepper spray exposure during military training. J Emerg Med 43:e149
TokudaY KM, Takahashi O, Stein GH (2006) Prehospital management of sarin nerve gas terrorism in urban settings: 10 years of progress after the Tokyo subway sarin attack. Resuscitation 68:193–202
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Belsey, S.L., Karch, S.B. (2020). Chemical Crowd Control Agents. In: Stark, M. (eds) Clinical Forensic Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-29462-5_6
Download citation
DOI: https://doi.org/10.1007/978-3-030-29462-5_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-29461-8
Online ISBN: 978-3-030-29462-5
eBook Packages: MedicineMedicine (R0)