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Other Mediastinal Tumors

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The Thorax

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Abstract

There is a variety of primary mediastinal tumors that include malignancies with heterogeneous histopathology. Each histology follows representative anatomical distribution according to compartments from the International Thymic Malignancy Interest Group (ITMIG) as follows: prevascular (anterior), visceral (middle), and paravertebral (posterior). Thereof, the anatomical location is a major determinant for differentiating mediastinal masses on cross-sectional imaging (Carter et al., J Thorac Oncol 9:S97–101, 2014). More than half of all mediastinal masses occur in the anterior compartment, with the thymus being the most common site of origin. Topics of this chapter are non-thymic mediastinal tumors, namely, neoplasms arising from lymphatic, germinal, mesenchymal, and neurogenic tissue.

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References

  1. Carter BW, Tomiyama N, Bhora FY, Rosado de Christenson ML, Nakajima J, Boiselle PM, Detterbeck FC, Marom EM. A modern definition of mediastinal compartments. J Thorac Oncol. 2014;9:S97–101.

    Article  PubMed  Google Scholar 

  2. Juanpere S, Cañete N, Ortuño P, Martínez S, Sanchez G, Bernado L. A diagnostic approach to the mediastinal masses. Insights Imaging. 2013;4:29–52.

    Article  PubMed  Google Scholar 

  3. Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest. 2005;128:2893–909.

    Article  PubMed  Google Scholar 

  4. Hodgkin Lymphoma – Cancer Stat Facts. In: SEER. https://seer.cancer.gov/statfacts/html/hodg.html. Accessed 29 Mar 2019.

  5. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117:5019–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC, Rosenberg SA, Coltman CA, Tubiana M. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol. 1989;7:1630–6.

    Article  CAS  PubMed  Google Scholar 

  7. Piña-Oviedo S, Moran CA. Primary mediastinal classical Hodgkin lymphoma. Adv Anat Pathol. 2016;23:285–309.

    Article  PubMed  CAS  Google Scholar 

  8. Kumar A, Burger IA, Zhang Z, et al. Definition of bulky disease in early stage Hodgkin lymphoma in computed tomography era: prognostic significance of measurements in the coronal and transverse planes. Haematologica. 2016;101:1237–43.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Marks LJ, McCarten KM, Pei Q, Friedman DL, Schwartz CL, Kelly KM. Pericardial effusion in Hodgkin lymphoma: a report from the Children’s Oncology Group AHOD0031 protocol. Blood. 2018;132:1208–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chiles C, Woodard PK, Gutierrez FR, Link KM. Metastatic involvement of the heart and pericardium: CT and MR imaging. Radiographics. 2001;21:439–49.

    Article  CAS  PubMed  Google Scholar 

  11. Gharbaran R, Park J, Kim C, Goy A, Suh KS. Circulating tumor cells in Hodgkin’s lymphoma – a review of the spread of HL tumor cells or their putative precursors by lymphatic and hematogenous means, and their prognostic significance. Crit Rev Oncol Hematol. 2014;89:404–17.

    Article  PubMed  Google Scholar 

  12. Castellino RA, Blank N, Hoppe RT, Cho C. Hodgkin disease: contributions of chest CT in the initial staging evaluation. Radiology. 1986;160:603–5.

    Article  CAS  PubMed  Google Scholar 

  13. Takahashi K, Al-Janabi NJ. Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging. 2010;32:1325–39.

    Article  PubMed  Google Scholar 

  14. Bouroncle BA. Sternberg-Reed cells in the peripheral blood of patients with Hodgkin’s disease. Blood. 1966;27:544–56.

    Article  CAS  PubMed  Google Scholar 

  15. Non-Hodgkin Lymphoma – Cancer Stat Facts. In: SEER. https://seer.cancer.gov/statfacts/html/nhl.html. Accessed 29 Mar 2019.

  16. Marx A, Chan JKC, Coindre J-M, et al. The 2015 World Health Organization classification of tumors of the thymus: continuity and changes. J Thorac Oncol. 2015;10:1383–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Martelli M, Ferreri A, Di Rocco A, Ansuinelli M, Johnson PWM. Primary mediastinal large B-cell lymphoma. Crit Rev Oncol Hematol. 2017;113:318–27.

    Article  PubMed  Google Scholar 

  18. Pfreundschuh M, Kuhnt E, Trümper L, et al. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol. 2011;12:1013–22.

    Article  CAS  PubMed  Google Scholar 

  19. You MJ, Medeiros LJ, Hsi ED. T-lymphoblastic leukemia/lymphoma. Am J Clin Pathol. 2015;144:411–22.

    Article  CAS  PubMed  Google Scholar 

  20. Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M. Lymphoblastic lymphoma. Crit Rev Oncol Hematol. 2017;113:304–17.

    Article  PubMed  Google Scholar 

  21. Tateishi U, Müller NL, Johkoh T, Onishi Y, Arai Y, Satake M, Matsuno Y, Tobinai K. Primary mediastinal lymphoma: characteristic features of the various histological subtypes on CT. J Comput Assist Tomogr. 2004;28:782–9.

    Article  PubMed  Google Scholar 

  22. Albany C, Einhorn LH. Extragonadal germ cell tumors. Curr Opin Oncol. 2013:1.

    Google Scholar 

  23. Stang A, Trabert B, Wentzensen N, Cook MB, Rusner C, Oosterhuis JW, McGlynn KA. Gonadal and extragonadal germ cell tumours in the United States, 1973–2007. Int J Androl. 2012;35:616–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. McKenney JK, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol. 2007;14:69–92.

    Article  PubMed  Google Scholar 

  25. Takeda S-I, Miyoshi S, Akashi A, Ohta M, Minami M, Okumura M, Masaoka A, Matsuda H. Clinical spectrum of primary mediastinal tumors: a comparison of adult and pediatric populations at a single Japanese institution. J Surg Oncol. 2003;83:24–30.

    Article  PubMed  Google Scholar 

  26. Moran CA, Suster S. Primary germ cell tumors of the mediastinum: I. analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer. 1997;80:681–90.

    Article  CAS  PubMed  Google Scholar 

  27. Williamson SR, Ulbright TM. Germ cell tumors of the mediastinum. In: Marchevsky AM, Wick MR, Marchevsky AM, Wick MR, editors. Pathology of the mediastinum. Cambridge: Cambridge University Press; 2014. p. 146–68.

    Chapter  Google Scholar 

  28. Kim HJ, Kim HR. Naturally occurring mediastinal teratoma with malignant transformation in an adult male. Korean J Thorac Cardiovasc Surg. 2013;46:305–8.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Moran CA, Suster S, Koss MN. Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum – a clinicopathologic and immunohistochemical study of 64 cases. Cancer. 1997;80:699–707.

    Article  CAS  PubMed  Google Scholar 

  30. Moran CA, Suster S, Przygodzki RM, Koss MN. Primary germ cell tumors of the mediastinum: II. Mediastinal seminomas – a clinicopathologic and immunohistochemical study of 120 cases. Cancer. 1997;80:691–8.

    Article  CAS  PubMed  Google Scholar 

  31. Takeda S-I, Miyoshi S, Ohta M, Minami M, Masaoka A, Matsuda H. Primary germ cell tumors in the mediastinum: a 50-year experience at a single Japanese institution. Cancer. 2003;97:367–76.

    Article  PubMed  Google Scholar 

  32. World Health Organization, International Agency for Research on Cancer, International Academy of Pathology. Pathology and genetics of tumours of the lung, pleura, thymus and heart. IARC Press; 2004. https://www.jto.org/article/S1556-0864(15)33571-1/fulltext.

  33. Fizazi K, Culine S, Droz JP, Kramar A, Théodore C, Ruffié P, Le Chevalier T. Primary mediastinal nonseminomatous germ cell tumors: results of modern therapy including cisplatin-based chemotherapy. J Clin Oncol. 1998;16:725–32.

    Article  CAS  PubMed  Google Scholar 

  34. Bokemeyer C, Nichols CR, Droz J-P, et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol. 2002;20:1864–73.

    Article  PubMed  Google Scholar 

  35. Malagón HD, Valdez AMC, Moran CA, Suster S. Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol. 2007;31:1356–62.

    Article  PubMed  Google Scholar 

  36. Dubashi B, Cyriac S, Tenali SG. Clinicopathological analysis and outcome of primary mediastinal malignancies – a report of 91 cases from a single institute. Ann Thorac Med. 2009;4:140–2.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Eimoto T, Kitaoka M, Ogawa H, Niwa H, Murase T, Tateyama H, Inagaki H, Soji T, Wang HJ. Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. Histopathology. 2002;40:46–57.

    Article  CAS  PubMed  Google Scholar 

  38. Okudela K, Nakamura N, Sano J, Ito T, Kitamura H. Thymic carcinosarcoma consisting of squamous cell carcinomatous and embryonal rhabdomyosarcomatous components. Report of a case and review of the literature. Pathol Res Pract. 2001;197:205–10.

    Article  CAS  PubMed  Google Scholar 

  39. Suster S, Moran CA, Chan JKC. Thymoma with pseudosarcomatous stroma: report of an unusual histologic variant of thymic epithelial neoplasm that may simulate carcinosarcoma. Am J Surg Pathol. 1997;21:1316–23.

    Article  CAS  PubMed  Google Scholar 

  40. den Bakker MA, Marx A, Mukai K, Ströbel P. Mesenchymal tumours of the mediastinum – part I. Virchows Arch. 2015;467:487–500.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Macchiarini P, Ostertag H. Uncommon primary mediastinal tumours. Lancet Oncol. 2004;5:107–18.

    Article  PubMed  Google Scholar 

  42. Hahn HP, Fletcher CDM. Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases. Am J Surg Pathol. 2007;31:1868–74.

    Article  PubMed  Google Scholar 

  43. Boland JM, Colby TV, Folpe AL. Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features. Am J Surg Pathol. 2012;36:1395–403.

    Article  PubMed  Google Scholar 

  44. Chen M, Yang J, Zhu L, Zhou C, Zhao H. Primary intrathoracic liposarcoma: a clinicopathologic study and prognostic analysis of 23 cases. J Cardiothorac Surg. 2014;9:119.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Nguyen DC, Olatubosun O, Yu W, Loor G, Burt BM. Giant mediastinal liposarcoma: a rare yet distinct clinical entity. Ann Thorac Surg. 2018;106:e117–9.

    Article  PubMed  Google Scholar 

  46. Galli A, Giordano L, Muriana P, Bandiera A, Negri G, Zannini P, Bussi M. Multidisciplinary management of a giant cervico-mediastinal liposarcoma: a case report and literature review. Ear Nose Throat J. 2017;96:E10–3.

    Article  PubMed  Google Scholar 

  47. Ortega P, Suster D, Falconieri G, Zambrano E, Moran CA, Morrison C, Suster S. Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. Mod Pathol. 2015;28:721–31.

    Article  CAS  PubMed  Google Scholar 

  48. Eisenhuber E, Herold C. Imaging of diseases of the chest, 3rd Edn. By P. Armstrong, A. G. Wilson, P. Dee and D. M. Hansell. Mosby, London, 2000. Price: £50. Clin Radiol. 2002;57:A1.

    Article  Google Scholar 

  49. Mikkilineni RS, Bhat S, Cheng AW, Prevosti LG. Liposarcoma of the posterior mediastinum in a child. Chest. 1994;106:1288–9.

    Article  CAS  PubMed  Google Scholar 

  50. Hirai S, Hamanaka Y, Mitsui N, Uegami S, Matsuura Y. Surgical resection of primary liposarcoma of the anterior mediastinum. Ann Thorac Cardiovasc Surg. 2008;14:38–41.

    PubMed  Google Scholar 

  51. Fletcher CDM. WHO classification of tumours of soft tissue and bone. World Health Organization; 2013. https://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&codcch=4005.

  52. Cohen AJ, Sbaschnig RJ, Hochholzer L, Lough FC, Albus RA. Mediastinal hemangiomas. Ann Thorac Surg. 1987;43:656–9.

    Article  CAS  PubMed  Google Scholar 

  53. Cakir E, Demirag F, Gulhan E, Oz G, Tastepez I. Mediastinal composite hemangioendothelioma. A rare tumor at an unusual location. Tumori. 2009;95:98–100.

    Article  PubMed  Google Scholar 

  54. Anderson T, Zhang L, Hameed M, Rusch V, Travis WD, Antonescu CR. Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol. 2015;39:132–9.

    Article  PubMed  PubMed Central  Google Scholar 

  55. D’Aiuto M, Veronesi G, Pompilio G, Gasparri R, Presicci F, Galetta D, Biglioli P, Spaggiari L. Extended right pneumonectomy with partial left atrial resection for primary leiomyosarcoma of the mediastinum. J Thorac Cardiovasc Surg. 2005;129:694–5.

    Article  PubMed  Google Scholar 

  56. Lee DH, Park C-K, Keum D-Y, Kim J-B, Hwang I. Leiomyosarcoma of the posterior mediastinum extending into the adjacent spinal canal. Korean J Thorac Cardiovasc Surg. 2012;45:192–5.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Moran CA, Suster S, Perino G, Kaneko M, Koss MN. Malignant smooth muscle tumors presenting as mediastinal soft tissue masses. A clinicopathologic study of 10 cases. Cancer. 1994;74:2251–60.

    Article  CAS  PubMed  Google Scholar 

  58. Chu WP, Department of Radiology, Princess Margaret Hospital, Laichikok, Hong Kong (currently at the Department of Radiology, Tseung Kwan O Hospital, O TK, Kong H)Anterior mediastinal alveolar rhabdomyosarcoma in an infant: rare site for a common paediatric tumour. Hong Kong Med J. 2013;19:458–9.

    Article  CAS  PubMed  Google Scholar 

  59. Sartelet S, Lantuejoul S, Armari-Alla C, Pin I, Delattre O, Brambilla E. Solid alveolar rhabdomyosarcoma of the thorax in a child. Histopathology. 1998;32:165–71.

    Article  CAS  PubMed  Google Scholar 

  60. Weidner N. Solitary fibrous tumor of the mediastinum. Ultrastruct Pathol. 1991;15:489–92.

    Article  CAS  PubMed  Google Scholar 

  61. Xue X, Chen J, Ma W, Zhu D, Zhang W, Chen G, Wei S, Zhou Q. Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. Surg Today. 2009;39:332–4.

    Article  PubMed  Google Scholar 

  62. Bouchikh M, Arame A, Riquet M, Le Pimpec-Barthes F. Cardiac failure due to a giant desmoid tumour of the posterior mediastinum. Eur J Cardiothorac Surg. 2013;44:1137–9.

    Article  PubMed  Google Scholar 

  63. Nakagiri T, Koseki M, Nakamoto K, Taniyama K. Paraesophageal mediastinal desmoid tumor: case report. Gen Thorac Cardiovasc Surg. 2007;55:125–9.

    Article  PubMed  Google Scholar 

  64. Warraich I, Dunn DM, Oliver JW. Solitary fibrous tumor of the orbit with epithelioid features. Arch Pathol Lab Med. 2006;130:1039–41.

    PubMed  Google Scholar 

  65. den Bakker MA, Marx A, Mukai K, Ströbel P. Mesenchymal tumours of the mediastinum – part II. Virchows Arch. 2015;467:501–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Corson JM, Weiss LM, Banks-Schlegel SP, Pinkus GS. Keratin proteins and carcinoembryonic antigen in synovial sarcomas: an immunohistochemical study of 24 cases. Hum Pathol. 1984;15:615–21.

    Article  CAS  PubMed  Google Scholar 

  67. Dickersin GR, Richard Dickersin G. Synovial sarcoma: a review and update, with emphasis on the ultrastructural characterization of the nonglandular component. Ultrastruct Pathol. 1991;15:379–402.

    Article  CAS  PubMed  Google Scholar 

  68. Fisher C. Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol. 1986;17:996–1008.

    Article  CAS  PubMed  Google Scholar 

  69. Krall RA, Kostianovsky M, Patchefsky AS. Synovial sarcoma. Am J Surg Pathol. 1981;5:137–51.

    Article  CAS  PubMed  Google Scholar 

  70. Salisbury JR, Isaacson PG. Synovial sarcoma: an immunohistochemical study. J Pathol. 1985;147:49–57.

    Article  CAS  PubMed  Google Scholar 

  71. Salter DM. Pulmonary and thoracic sarcomas. Curr Diagn Pathol. 2006;12:409–17.

    Article  Google Scholar 

  72. Salah S, Salem A. Primary synovial sarcomas of the mediastinum: a systematic review and pooled analysis of the published literature. ISRN Oncol. 2014;2014:412527.

    PubMed  PubMed Central  Google Scholar 

  73. Suster S, Moran CA. Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol. 2005;29:569–78.

    Article  PubMed  Google Scholar 

  74. Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol. 2008;97:314–20.

    Article  PubMed  Google Scholar 

  75. Rossi S, Nascimento AG, Canal F, Tos APD. Small round-cell neoplasms of soft tissues: an integrated diagnostic approach. Curr Diagn Pathol. 2007;13:150–63.

    Article  Google Scholar 

  76. Stanelle EJ, Christison-Lagay ER, Healey JH, Singer S, Meyers PA, La Quaglia MP. Pediatric and adolescent synovial sarcoma: multivariate analysis of prognostic factors and survival outcomes. Ann Surg Oncol. 2013;20:73–9.

    Article  PubMed  Google Scholar 

  77. Wisanuyotin T, Radapat K, Sirichativapee W, Paholpak P, Kosuwon W, Sumnanoont C, Jeeravipoolvarn P. Prognostic factors and clinical outcomes in synovial sarcoma of the extremities. Asia Pac J Clin Oncol. 2013;9:80–5.

    Article  PubMed  Google Scholar 

  78. Eilber FC, Brennan MF, Eilber FR, Eckardt JJ, Grobmyer SR, Riedel E, Forscher C, Maki RG, Singer S. Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann Surg. 2007;246:105–13.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Deshmukh R, Mankin HJ, Singer S. Synovial sarcoma: the importance of size and location for survival. Clin Orthop Relat Res. 2004;419:155–61.

    Article  Google Scholar 

  80. Balieiro MA, Lopes AJ, Costa BP, Veras GPM, Perelson PS, Acatauassú Nunes R, Saito EH. The surprising outcome of a giant primary mediastinal synovial sarcoma treated with neoadjuvant chemotherapy. J Thorac Dis. 2013;5:94–6.

    PubMed  PubMed Central  Google Scholar 

  81. Zhou Y, Dong W, Zou F, Zhou D-A, Ma J-A. Primary giant mediastinal synovial sarcoma of the neck: a case report and review of the literature. Oncol Lett. 2014;7:140–4.

    Article  PubMed  Google Scholar 

  82. Nakazono T, White CS, Yamasaki F, Yamaguchi K, Egashira R, Irie H, Kudo S. MRI findings of mediastinal neurogenic tumors. AJR Am J Roentgenol. 2011;197:W643–52.

    Article  PubMed  Google Scholar 

  83. Tanaka O, Kiryu T, Hirose Y, Iwata H, Hoshi H. Neurogenic tumors of the mediastinum and chest wall: MR imaging appearance. J Thorac Imaging. 2005;20:316–20.

    Article  PubMed  Google Scholar 

  84. Pilavaki M, Chourmouzi D, Kiziridou A, Skordalaki A, Zarampoukas T, Drevelengas A. Imaging of peripheral nerve sheath tumors with pathologic correlation: pictorial review. Eur J Radiol. 2004;52:229–39.

    Article  CAS  PubMed  Google Scholar 

  85. Skovronsky DM, Oberholtzer JC. Pathologic classification of peripheral nerve tumors. Neurosurg Clin N Am. 2004;15:157–66.

    Article  PubMed  Google Scholar 

  86. Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. From the archives of the AFIP. Radiographics. 2002;22:911–34.

    Article  PubMed  Google Scholar 

  87. Pavlus JD, Carter BW, Tolley MD, Keung ES, Khorashadi L, Lichtenberger JP 3rd. Imaging of thoracic neurogenic tumors. AJR Am J Roentgenol. 2016;207:552–61.

    Article  PubMed  Google Scholar 

  88. Brisse HJ, McCarville MB, Granata C, et al. Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology. 2011;261:243–57.

    Article  PubMed  Google Scholar 

  89. Kamran SC, Shinagare AB, Howard SAH, Nishino M, Hornick JL, Krajewski KM, Ramaiya NH. Intrathoracic malignant peripheral nerve sheath tumors: imaging features and implications for management. Radiol Oncol. 2013;47:230–8.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Wen Y, Peng Y, Duan XM, Zhang N. Role of diffusion-weighted imaging in distinguishing thoracoabdominal neuroblastic tumours of various histological types and differentiation grades. J Med Imaging Radiat Oncol. 2017;61:718–24.

    Article  PubMed  Google Scholar 

  91. Suster S, Moran CA. Neuroendocrine neoplasms of the mediastinum. Am J Clin Pathol. 2001;115(Suppl):S17–27.

    PubMed  Google Scholar 

  92. Baldassarre RL, Nakanote KA, Hughes TH. Imaging of peripheral neurogenic tumors. In: Handbook of neuro-oncology neuroimaging; Herbert Newton; 2016. p. 777–96.

    Chapter  Google Scholar 

  93. He W-G, Yan Y, Tang W, Cai R, Ren G. Clinical and biological features of neuroblastic tumors: a comparison of neuroblastoma and ganglioneuroblastoma. Oncotarget. 2017;8:37730–9.

    PubMed  PubMed Central  Google Scholar 

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Milone, F., Taronna, G., Gnetti, L., Silva, M. (2020). Other Mediastinal Tumors. In: Sverzellati, N., Silva, M. (eds) The Thorax. Cancer Dissemination Pathways. Springer, Cham. https://doi.org/10.1007/978-3-030-27233-3_7

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