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Pediatric Rhinosinusitis and Gastroesophageal Reflux

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Pediatric Rhinosinusitis
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Abstract

Gastroesophageal reflux disease is a common occurrence in the pediatric age group and tends to improve with age. A relationship between pediatric chronic rhinosinusitis and gastroesophageal reflux has been speculated, though a true cause-and-effect relationship has yet to be solidified. Available evidence linking gastroesophageal reflux disease to pediatric rhinosinusitis will be reviewed in this chapter. Similarly, the impact of reflux therapy on the progress of rhinosinusitis in children will be summarized. Based on the current literature, there appears to be some correlation between the two entities, but the evidence does not seem to justify routine empiric treatment of reflux in children with chronic rhinosinusitis in the absence of overt gastroesophageal reflux disease symptoms.

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References

  1. Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, et al. Pediatric gastroesophageal reflux clinical practice guidelines. J Pediatr Gastroenterol Nutr. 2018;66(3):516–54.

    Article  Google Scholar 

  2. Keles B, Ozturk K, Arbag H, Gunel E, Ozer B. Frequency of pharyngeal reflux in children with adenoid hyperplasia. Int J Pediatr Otorhinolaryngol. 2005;69(8):1103–7.

    Article  Google Scholar 

  3. Vandenplas Y, Sacré-Smits L. Continuous 24-hour esophageal pH monitoring in 285 asymptomatic infants 0-15 months old. J Pediatr Gastroenterol Nutr. 1987;6(2):220–4.

    Article  CAS  Google Scholar 

  4. Shepherd RW, Wren J, Evans S, Lander M, Ong TH. Gastroesophageal reflux in children. Clin Pediatr (Phila). 1987;26(2):55–60.

    Article  CAS  Google Scholar 

  5. Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during infancy: a pediatric practice-based survey. Arch Pediatr Adolesc Med. 1997;151(6):569–72.

    Article  CAS  Google Scholar 

  6. Henry SM. Discerning differences: Gastroesophageal reflux and gastroesophageal reflux disease in infants. Adv Neonatal Care. 2004;4(4):235–47.

    Article  Google Scholar 

  7. Leason SR, Barham HP, Oakley G, Rimmer J, DelGaudio JM, Christensen JM, et al. Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis. Rhinology. 2017;55(1):3–16.

    Article  CAS  Google Scholar 

  8. Contencin P, Narcy P. Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis. Int J Pediatr Otorhinolaryngol. 1991;22(3):249–56.

    Article  CAS  Google Scholar 

  9. Orenstein SR, Shalaby TM, Cohn JF. Reflux symptoms in 100 normal infants: diagnostic validity of the infant gastroesophageal reflux questionnaire. Clin Pediatr (Phila). 1996;35(12):607–14.

    Article  CAS  Google Scholar 

  10. Orenstein SR, Kartan R, Cohn JF, Shalaby TM. Reliability and validity of an infant gastroesophageal reflux questionnaire. Clin Pediatr (Phila). 1993;32(8):472–84.

    Article  CAS  Google Scholar 

  11. Aggarwal S, Mittal SK, Kalra KK, Rajeshwari K, Gondal R. Infant gastroesophageal reflux disease score: reproducibility and validity in a developing country. Trop Gastroenterol. 2004;25(2):96–8.

    PubMed  Google Scholar 

  12. Størdal K, Johannesdottir GB, Bentsen BS, Sandvik L. Gastroesophageal reflux disease in children: association between symptoms and pH monitoring. Scand J Gastroenterol. 2005;40(6):636–40.

    Article  Google Scholar 

  13. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Coletti RB, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001;32(Suppl2):S1–31.

    Article  Google Scholar 

  14. Wilder-Smith CH, Ernst T, Gennoni M, Zeyen B, Halter F, Merki HS. Tolerance to oral H2-receptor antagonists. Dig Dis Sci. 1990;35(8):976–83.

    Article  CAS  Google Scholar 

  15. Dalby-Payne JR, Morris AM, Craig JC. Meta-analysis of randomized controlled trials on the benefits and risks of using cisapride for the treatment of gastroesophageal reflux in children. J Gastroenterol Hepatol. 2003;18(2):196–202.

    Article  CAS  Google Scholar 

  16. Vandenplas Y. Management of paediatric GERD. Nat Rev Gastroenterol Hepatol. 2014;11(3):147–57.

    Article  CAS  Google Scholar 

  17. Ericson JE, Arnold C, Cheeseman J, Cho J, Kaneko S, Wilson E, et al. Use and safety of erythromycin and metoclopramide in hospitalized infants. J Pediatr Gastroenterol Nutr. 2015;61(3):334–9.

    Article  CAS  Google Scholar 

  18. Oei J, Lui K. A placebo-controlled trial of low-dose erythromycin to promote feed tolerance in preterm infants. Acta Paediatr. 2001;90(8):904–8.

    Article  CAS  Google Scholar 

  19. Ballengee CR, Davalian F, Conaway MR, Sauer CG, Kaufman DA. Erythromycin and reflux events in premature neonates. J Pediatr Gastroenterol Nutr. 2018;67(6):720–5.

    Article  CAS  Google Scholar 

  20. Björnsson E, Abrahamsson H, Simrén M, Mattsson N, Jensen C, Agerforz P, et al. Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trial. Aliment Pharmacol Ther. 2006;24(6):945–54.

    Article  Google Scholar 

  21. El-Serag HB, Gilger M, Kuebeler M, Rabeneck L. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology. 2001;121(6):1294–9.

    Article  CAS  Google Scholar 

  22. Greifer M, Ng K, Levine J. Impedance and extraesophageal manifestations of reflux in pediatrics. Laryngoscope. 2012;122(6):1397–400.

    Article  Google Scholar 

  23. Katle EJ, Hatlebakk JG, Grimstad T, Kvaloy JT, Karmhus Steinsvag S. Gastro-oesophageal reflux in patients with chronic rhinosinusitis investigated with multichannel impedance - pH monitoring. Rhinology. 2017;55(1):27–33.

    Article  CAS  Google Scholar 

  24. Wang J, Yu Z, Ren J, Xu Y, Zhang Y, Lei L, et al. Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis. Acta Otolaryngol. 2017;137(12):1253–9.

    Article  CAS  Google Scholar 

  25. Johnston N, Dettmar PW, Bishwokarma B, Lively MO, Koufman JA. Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope. 2007;117(6):1036–9.

    Article  Google Scholar 

  26. Johnston N, Yan JC, Hoekzema CR, Samuels TL, Stoner GD, Blumin JH, et al. Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells. Laryngoscope. 2012;122(6):1317–25.

    Article  CAS  Google Scholar 

  27. Ren J, Zhao Y, Wang J, Ren X, Xu Y, Tang W, et al. PepsinA as a marker of laryngopharyngeal reflux detected in chronic rhinosinusitis patients. Otolaryngol Head Neck Surg. 2017;156(5):893–900.

    Article  Google Scholar 

  28. DiBaise JK, Huerter JV, Quigley EM. Sinusitis and gastroesophageal reflux disease. Ann Intern Med. 1998;129(12):1078.

    Article  CAS  Google Scholar 

  29. Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children. Lancet. 2002;359(9305):493.

    Article  Google Scholar 

  30. Lieu JE, Muthappan PG, Uppaluri R. Association of reflux with otitis media in children. Otolaryngol Head Neck Surg. 2005;133(3):357–61.

    Article  Google Scholar 

  31. Lupa M, DelGaudio JM. Evidence-based practice. Reflux in sinusitis. Otolaryngol Clin N Am. 2012;45(5):983–92.

    Article  Google Scholar 

  32. Koc C, Arikan OK, Atasoy P, Aksoy A. Prevalence of Helicobacter pylori in patients with nasal polyps: a preliminary report. Laryngoscope. 2004;114(11):1941–4.

    Article  Google Scholar 

  33. Morinaka S, Ichimiya M, Nakamura H. Detection of Helicobacter pylori in nasal and maxillary sinus specimens from patients with chronic sinusitis. Laryngoscope. 2003;113(9):1557–63.

    Article  Google Scholar 

  34. Heath J, Hartzell L, Putt C, Kennedy JL. Chronic rhinosinusitis in children: pathophysiology, evaluation, and medical management. Curr Allergy Asthma Rep. 2018;18(7):37.

    Article  Google Scholar 

  35. Chang AB, Cox NC, Faoagali J, Cleghorn GJ, Beem C, Ee LC, et al. Cough and reflux esophagitis in children: their co-existence and airway cellularity. BMC Pediatr. 2006;6:4.

    Article  Google Scholar 

  36. Ulualp SO, Toohill RJ. Laryngopharyngeal reflux: state of the art diagnosis and treatment. Otolaryngol Clin N Am. 2000;33(4):785–802.

    Article  CAS  Google Scholar 

  37. Önal Z, Çullu-Çokuğraş F, Işıldak H, Kaytaz A, Kutlu T, Erkan T, et al. Evaluation of the likelihood of reflux developing in patients with recurrent upper respiratory infections, recurrent sinusitis or recurrent otitis seen in ear-nose-throat outpatient clinics. Turk J Pediatr. 2015;57(3):258–65.

    PubMed  Google Scholar 

  38. DelGaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope. 2005;115(6):946–57.

    Article  Google Scholar 

  39. Carr MM, Poje CP, Ehrig D, Brodsky LS. Incidence of reflux in young children undergoing adenoidectomy. Laryngoscope. 2001;111(12):2170–2.

    Article  CAS  Google Scholar 

  40. Brietzke SE, Shin JJ, Choi S, Lee JT, Parikh SR, Pena M, et al. Clinical consensus statement. Otolaryngol Head Neck Surg. 2014;151(4):542–53.

    Article  Google Scholar 

  41. Nation J, Kaufman M, Allen M, Sheyn A, Coticchia J. Incidence of gastroesophageal reflux disease and positive maxillary antral cultures in children with symptoms of chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol. 2014;78(2):218–22.

    Article  Google Scholar 

  42. Delehaye E, Dore MP, Bozzo C, Mameli L, Delitala G, Meloni F. Correlation between nasal mucociliary clearance time and gastroesophageal reflux disease: our experience on 50 patients. Auris Nasus Larynx. 2009;36(2):157–61.

    Article  CAS  Google Scholar 

  43. Schan CA, Harding SM, Haile JM, Bradley LA, Richter JE. Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology. Chest. 1994;106(3):731–7.

    Article  CAS  Google Scholar 

  44. Wong IW, Rees G, Greiff L, Myers JC, Jamieson GG, Wormald P-J. Gastroesophageal reflux disease and chronic sinusitis: in search of an esophageal-nasal reflex. Am J Rhinol Allergy. 2010;24(4):255–9.

    Article  Google Scholar 

  45. Megale SRMCL, Scanavini ABA, Andrade EC, Fernandes MIM, Anselmo-Lima WT. Gastroesophageal reflux disease: its importance in ear, nose, and throat practice. Int J Pediatr Otorhinolaryngol. 2006;70(1):81–8.

    Article  Google Scholar 

  46. Pincus RL, Kim HH, Silvers S, Gold S. A study of the link between gastric reflux and chronic sinusitis in adults. Ear Nose Throat J. 2006;85(3):174–8.

    Article  Google Scholar 

  47. Slavin RG, Spector SL, Bernstein IL, Kaliner MA, Kennedy DW, Virant FS, et al. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol. 2005;116(6 Suppl):S13–47.

    Article  Google Scholar 

  48. Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg. 2000;126(7):831–6.

    Article  CAS  Google Scholar 

  49. Bothwell MR, Parsons DS, Talbot A, Barbero GJ, Wilder B. Outcome of reflux therapy on pediatric chronic sinusitis. Otolaryngol Head Neck Surg. 1999;121(3):255–62.

    Article  CAS  Google Scholar 

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Correspondence to Fuad M. Baroody .

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Sowa, L., Baroody, F.M. (2020). Pediatric Rhinosinusitis and Gastroesophageal Reflux. In: Ramadan, H., Baroody, F. (eds) Pediatric Rhinosinusitis. Springer, Cham. https://doi.org/10.1007/978-3-030-22891-0_11

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  • DOI: https://doi.org/10.1007/978-3-030-22891-0_11

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