Skip to main content
SpringerLink
Log in

Women’s Health and Aging Studies

  • Reference work entry
  • First Online:
Encyclopedia of Gerontology and Population Aging

  • 57 Accesses

Synonyms

Aging cohort; Health; Longitudinal; Older women; WHAS I and II; WHAS III

Overview

The Women’s Health and Aging Studies (WHAS) I and II were designed as two companion prospective observational cohort studies, to determine the causes, course, and consequences of functional decline and disability in older women living in the community. These studies were focused on women because they have a higher prevalence of disability in old age than men, they live longer with their disability, and they require greater use of medical and long-term care resources. The WHAS I study focused on older women who already had moderate to severe disability but were still residing in the community and was aimed at intensively studying the characteristics of this disability at a level of detail not previously attempted. It also focused on identifying the contributions to disability of specific diseases and combinations of diseases, as well as demographic, behavioral, and psychosocial characteristics,...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Bandeen-Roche K, Xue QL, Ferrucci L et al (2006) Phenotype of frailty: characterization in the women’s health and aging studies. J Gerontol A Biol Sci Med Sci 61(3):262–266. PMID: 16567375

    Google Scholar 

  • Boyd CM, Ricks M, Fried LP et al (2009) Functional decline and recovery of activities of daily living in hospitalized, disabled older women: the Women’s Health and Aging Study I. J Am Geriatr Soc 57(10):1757–1766. https://doi.org/10.1111/j.1532-5415.2009.02455.x. Epub 2009 Aug 20

    Article  Google Scholar 

  • Carlson MC, Fried LP et al (2005) Validation of the Hopkins medication schedule to identify difficulties in taking medications. J Gerontol A Biol Sci Med Sci 60(2):217–223

    Google Scholar 

  • Carlson MC, Xue QL, Zhou J, Fried LP (2009) Executive decline and dysfunction precedes declines in memory: the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci 64(1):110–117. PMID: 19182230

    Google Scholar 

  • Chaves PH, Garrett ES et al (2000) Predicting the risk of mobility difficulty in older women with screening nomograms: the Women’s Health and Aging Study II. Arch Intern Med 160(16):2525–2533

    Google Scholar 

  • Cohen AA, Milot E, Li Q et al (2015) Detection of a novel, integrative aging process suggests complex physiological integration. PLoS One 10(3):e0116489. https://doi.org/10.1371/journal.pone.0116489.

    Article  Google Scholar 

  • Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, Leveille SG, Fried LP, Guralnik JM (2002) Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 50(12):1947–54

    Google Scholar 

  • Fried LP, Bandeen-Roche K, Williamson JD et al (1996) Functional decline in older adults: expanding methods of ascertainment. J Gerontol Ser A 51(5):M206–M214. PMID: 8808990

    Google Scholar 

  • Fried LP, Bandeen-Roche K et al (2000) Preclinical mobility disability predicts incident mobility disability in older women. J Gerontol A Biol Sci Med Sci 55(1):M43–M52

    Google Scholar 

  • Fried LP, Young Y et al (2001) Self-reported preclinical disability identifies older women with early declines in performance and early disease. J Clin Epidemiol 54(9):889–901

    Google Scholar 

  • Fried LP, Xue QL, Cappola AR et al (2009) Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 64(10):1049–1057. PMID: 19567825

    Google Scholar 

  • González-Fernández M, Humbert I, Winegrad H, Cappola AR, Fried LP (2014) Dysphagia in old-old women: prevalence as determined according to self-report and the 3-ounce water swallowing test. J Am Geriatr Soc 62(4):716–720

    Google Scholar 

  • Gregory PC, Fried LP (2003) Why do older adults decide they are having difficulty with a task? Am J Phys Med Rehabil 82(1):9–16

    Google Scholar 

  • Gregory PC, Szanton SL, Xue QL, Tian J, Thorpe RJ, Fried LP (2011) Education predicts incidence of preclinical mobility disability in initially high-functioning older women. The Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci 66(5):577–581

    Google Scholar 

  • Guralnik JM, Fried LP, Simonsick EM, Kasper JD, Lafferty ME, (eds) (1995) The Women’s Health and Aging Study: health and social characteristics of older women with disability. NIH Pub. No. 95-4009, National Institute on Aging, Bethesda

    Google Scholar 

  • Guralnik JM, Ferrucci L, Penninx BW, Kasper JD, Leveille SG, Bandeen-Roche K, Fried LP (1999) New and worsening conditions and change in physical and cognitive performance during weekly evaluations over 6 months: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 54(8):M410–M422

    Google Scholar 

  • Kalyani RR, Tian J, Xue QL, Walston J, Cappola AR, Fried LP, Brancati FL, Blaum CS (2012a) Hyperglycemia and incidence of frailty and lower extremity mobility limitations in older women. J Am Geriatr Soc 60(9):1701–1707. https://doi.org/10.1111/j.1532-5415.2012.04099.x

    Article  Google Scholar 

  • Kalyani RR, Varadhan R, Weiss CO, Fried LP, Cappola A (2012b) Frailty status and altered glucose-insulin dynamics. J Gerontol A Biol Sci Med Sci 67(12):1300–1306. https://doi.org/10.1093/gerona/glr141

    Article  Google Scholar 

  • Krall JR, Carlson MC, Fried LP, Xue QL (2014) Examining the dynamic, bidirectional associations between cognitive and physical functioning in older adults. Am J Epidemiol 180(8):838–846. https://doi.org/10.1093/aje/kwu198. Epub 2014 Sep 8

    Article  Google Scholar 

  • Onder G, Penninx BW, Lapuerta P, Fried LP, Ostir GV, Guralnik JM, Pahor M (2002) Change in physical performance over time in older women: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 57(5):M289–M293

    Google Scholar 

  • Parisi JM, Xia J, Spira AP, Xue QL, Rieger ML, Rebok GW, Carlson MC (2014) The association between lifestyle activities and late-life depressive symptoms. Act Adapt Aging 38(1):1–10

    Google Scholar 

  • Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP (2000) Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women’s Health and Aging Study. Am J Psychiatry 157(5):715–721

    Google Scholar 

  • Rathouz PJ, Kasper JD, Zeger SL, Ferrucci L, Bandeen-Roche K, Miglioretti DL, Fried LP (1998) Short-term consistency in self-reported physical functioning among elderly women: the Women’s Health and Aging Study. Am J Epidemiol 147(8):764–773

    Google Scholar 

  • Simonsick EM, Maffeo CE, Rogers SK, Skinner EA, Davis D, Guralnik JM, Fried LP (1997) Methodology and feasibility of a home-based examination in disabled older women: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 52(5):M264–74

    Google Scholar 

  • Simonsick EM, Guralnik JM, Fried LP (1999) Who walks? Factors associated with walking behavior in disabled older women with and without self-reported walking difficulty. J Am Geriatr Soc 47(6):672–680

    Google Scholar 

  • Simonsick EM, Kasper JD, Guralnik JM, Bandeen-Roche K, Ferrucci L, Hirsch R, Leveille S, Rantanen T, Fried LP (2001) Severity of upper and lower extremity functional limitation: scale development and validation with self-report and performance-based measures of physical function. WHAS Research Group. Women’s Health and Aging Study. J Gerontol B Psychol Sci Soc Sci 56(1):S10–S19

    Google Scholar 

  • Volpato S, Blaum C, Resnick H, Ferrucci L, Fried LP, Guralnik JM, Women’s Health and Aging Study (2002) Comorbidities and impairments explaining the association between diabetes and lower extremity disability: the Women’s Health and Aging Study. Diabetes Care 25(4):678–683

    Google Scholar 

  • Weiss CO, Wolff JL, Egleston B, Seplaki CL, Fried LP (2012) Incident preclinical mobility disability (PCMD) increases future risk of new difficulty walking and reduction in walking activity. Arch Gerontol Geriatr 54(3):e329–33

    Google Scholar 

  • Xue QL, Bandeen-Roche K, Mielenz TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Varadhan R, Yao W, Fried LP (2012) Patterns and predictors of 12-year change in physical activity in community-dwelling older women: can modest levels of physical activity help older women live longer? Am J Epidemiol 176(6):534–43

    Google Scholar 

  • Xue QL, Guralnik JM, Beamer BA, Fried LP, Chaves PH (2015) Monitoring 6-month trajectory of grip strength improves the prediction of long-term change in grip strength in disabled older women. J Gerontol A Biol Sci Med Sci 70(3):367–373

    Google Scholar 

  • Yao X, Hamilton RG, Weng NP et al (2011) Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults. Vaccine 29(31):5015–5021. PMID:21565245

    Google Scholar 

  • Young Y, Boyd CM, Guralnik JM, Fried LP (2010) Does self-reported function correspond to objective measures of functional impairment? J Am Med Dir Assoc 11(9):645–653. PMID: 21029999

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Columbia University Mailman School of Public Health, New York, NY, USA

    Linda P. Fried

  2. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Karen Bandeen-Roche

  3. University of Maryland School of Medicine, Baltimore, MD, USA

    Jack M. Guralnik

Authors
  1. Linda P. Fried
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karen Bandeen-Roche
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jack M. Guralnik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Linda P. Fried .

Editor information

Editors and Affiliations

  1. Population Division, Department of Economics and Social Affairs, United Nations, New York, NY, USA

    Danan Gu

  2. Department of Population Health Sciences, Department of Sociology, Duke University, Durham, NC, USA

    Matthew E. Dupre

Section Editor information

  1. Department of Population Health Sciences - Department of Sociology, Center for the Study of Aging and Human Development, Duke University, Durham, NC, USA

    Matthew E. Dupre Ph.D.

  2. Duke Clinical Research Institute, School of Medicine, Duke University, Durham, NC, USA

    Matthew E. Dupre Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Fried, L.P., Bandeen-Roche, K., Guralnik, J.M. (2021). Women’s Health and Aging Studies. In: Gu, D., Dupre, M.E. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. https://doi.org/10.1007/978-3-030-22009-9_762

Download citation

Publish with us

Policies and ethics

Search

Navigation