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Genomics of Aging and Longevity

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Encyclopedia of Gerontology and Population Aging

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Synonyms

Genetics and epigenetics of aging and longevity; Genomics of centenarians; Genomics of healthy aging; Genomics of healthy lifespan

Definition

Genomics of aging and longevity encompasses the fields of genomics and epigenomics implemented towards the understanding of a healthy aging phenotype. Exceptionally long-lived individuals (centenarians) are used as a model for longevity alongside animal and cell models that are used for mechanism and pathway illustration and elucidation.

Overview

Aging can be defined as a progressive decline in organ function and is considered the main risk factor for chronic disease, weakened health, and increased risk of morality (Macedo et al. 2017). Aging research has progressed in recent years, especially since it has been found to be mediated, at least to some extent, by genetic pathways and biochemical processes (López-Otín et al. 2013). Further, longevity is one of the most complex phenotypes (Brooks-Wilson 2013) with studies centering on...

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Authors and Affiliations

  1. Faculty of Natural Science, University of Haifa, Haifa, Israel

    Ghadeer Falah, Danielle Gutman & Gil Atzmon

Authors
  1. Ghadeer Falah
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  2. Danielle Gutman
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  3. Gil Atzmon
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Corresponding author

Correspondence to Gil Atzmon .

Editor information

Editors and Affiliations

  1. Population Division, Department of Economics and Social Affairs, United Nations, New York, NY, USA

    Danan Gu

  2. Department of Population Health Sciences, Department of Sociology, Duke University, Durham, NC, USA

    Matthew E. Dupre

Section Editor information

  1. Department of Human Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA, USA

    Diddahally R. Govindaraju

  2. The Institute for Aging Research, The Glenn Center for the Biology of Human Aging, Albert Einstein College of Medicine, Bronx, NY, USA

    Diddahally R. Govindaraju

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Falah, G., Gutman, D., Atzmon, G. (2021). Genomics of Aging and Longevity. In: Gu, D., Dupre, M.E. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. https://doi.org/10.1007/978-3-030-22009-9_730

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