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Analgesia, Sedation, and Neuromuscular Blockade in PARDS

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Pediatric Acute Respiratory Distress Syndrome

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Abstract

Sedation and analgesia are provided to most children with pediatric acute respiratory distress syndrome in order to keep them comfortable, facilitate synchrony with the ventilator, and prevent dislodgement of life-sustaining instruments. This chapter reviews commonly used medications including opiates, benzodiazepines, and dexmedetomidine and discusses clinically relevant advantages and disadvantages. Neuromuscular-blocking agents are also commonly used in this patient population and have been shown to improve outcomes in adults with acute respiratory distress syndrome. Commonly used agents are reviewed. Adverse effects of all of these medication classes are also reviewed, including delirium, withdrawal, and long-term neurologic morbidity.

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Authors and Affiliations

  1. Department of Anesthesiology and Division of Pediatric Critical Care, John R. Oishei Children’s Hospital, University at Buffalo, Buffalo, NY, USA

    Christopher Heard

  2. Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA

    Joseph Tobias

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  1. Christopher Heard
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Editors and Affiliations

  1. Rainbow Babies & Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA

    Steven L. Shein

  2. Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA

    Alexandre T. Rotta

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Heard, C., Tobias, J. (2020). Analgesia, Sedation, and Neuromuscular Blockade in PARDS. In: Shein, S., Rotta, A. (eds) Pediatric Acute Respiratory Distress Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-030-21840-9_11

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